دورية أكاديمية
High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats.
العنوان: | High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats. |
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المؤلفون: | Paulo SL; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal., Miranda-Lourenço C; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal., Belo RF; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal., Rodrigues RS; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal., Fonseca-Gomes J; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal., Tanqueiro SR; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal., Geraldes V; Instituto de Fisiologia, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Centro Cardiovascular da Universidade de Lisboa, 1649-028 Lisboa, Portugal., Rocha I; Instituto de Fisiologia, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Centro Cardiovascular da Universidade de Lisboa, 1649-028 Lisboa, Portugal., Sebastião AM; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal., Xapelli S; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal., Diógenes MJ; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal. |
المصدر: | Current issues in molecular biology [Curr Issues Mol Biol] 2021 Dec 18; Vol. 43 (3), pp. 2305-2319. Date of Electronic Publication: 2021 Dec 18. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100931761 Publication Model: Electronic Cited Medium: Internet ISSN: 1467-3045 (Electronic) Linking ISSN: 14673037 NLM ISO Abbreviation: Curr Issues Mol Biol |
أسماء مطبوعة: | Publication: 2021- : Basel, Switzerland : MDPI Original Publication: Wymondham, Norfolk, UK : Caister Academic Press, |
مواضيع طبية MeSH: | Diet* , Neuronal Plasticity*, Memory Disorders/*etiology, Age Factors ; Animals ; Biomarkers ; Brain/metabolism ; Disease Models, Animal ; Eating ; Immunohistochemistry ; Male ; Rats |
مستخلص: | The increasing consumption of sugar and fat seen over the last decades and the consequent overweight and obesity, were recently linked with a deleterious effect on cognition and synaptic function. A major question, which remains to be clarified, is whether obesity in the elderly is an additional risk factor for cognitive impairment. We aimed at unravelling the impact of a chronic high caloric diet (HCD) on memory performance and synaptic plasticity in aged rats. Male rats were kept on an HCD or a standard diet (control) from 1 to 24 months of age. The results showed that under an HCD, aged rats were obese and displayed significant long-term recognition memory impairment when compared to age-matched controls. Ex vivo synaptic plasticity recorded from hippocampal slices from HCD-fed aged rats revealed a reduction in the magnitude of long-term potentiation, accompanied by a decrease in the levels of the brain-derived neurotrophic factor receptors TrkB full-length (TrkB-FL). No alterations in neurogenesis were observed, as quantified by the density of immature doublecortin-positive neurons in the hippocampal dentate gyrus. This study highlights that obesity induced by a chronic HCD exacerbates age-associated cognitive decline, likely due to impaired synaptic plasticity, which might be associated with deficits in TrkB-FL signaling. |
References: | Appl Physiol Nutr Metab. 2018 Oct;43(10):1083-1089. (PMID: 29726700) Br J Psychiatry. 2009 Nov;195(5):408-13. (PMID: 19880930) Neuropharmacology. 2017 Mar 1;114:12-19. (PMID: 27889488) J Neurosci Methods. 2001 Jul 15;108(1):71-83. (PMID: 11459620) Neurobiol Aging. 2016 Nov;47:63-70. (PMID: 27562529) Front Immunol. 2017 Dec 07;8:1745. (PMID: 29270179) Neural Plast. 2002;9(4):217-32. (PMID: 12959152) Science. 1972 Jan 7;175(4017):87-9. (PMID: 5008585) Neurobiol Aging. 2007 Jul;28(7):1088-98. (PMID: 16769156) Neurology. 2001 Jun 26;56(12):1683-9. (PMID: 11425934) Nat Rev Neurosci. 2009 Dec;10(12):850-60. (PMID: 19927149) eNeuro. 2020 Jan 6;7(1):. (PMID: 31871124) Cell Tissue Res. 2018 Jan;371(1):105-113. (PMID: 29124393) Nutrients. 2015 Aug 12;7(8):6719-38. (PMID: 26274972) Am Heart J. 2017 Oct;192:1-12. (PMID: 28938955) J Am Geriatr Soc. 2009 Jan;57(1):115-9. (PMID: 19054178) Arch Neurol. 2005 Oct;62(10):1556-60. (PMID: 16216938) J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(9):1224-33. (PMID: 22540644) Hippocampus. 2008;18(11):1085-8. (PMID: 18651634) Endocrinology. 2008 Mar;149(3):1038-48. (PMID: 18063676) Nutrients. 2020 Jun 19;12(6):. (PMID: 32575416) Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6170-6177. (PMID: 32127481) Neurobiol Aging. 2017 Oct;58:88-101. (PMID: 28719855) Aging Clin Exp Res. 2016 Apr;28(2):303-11. (PMID: 26138818) Cold Spring Harb Perspect Med. 2018 Apr 2;8(4):. (PMID: 28495803) Neurobiol Learn Mem. 2018 Nov;155:197-207. (PMID: 30075193) Alzheimers Dement. 2018 Feb;14(2):178-186. (PMID: 28943197) J Physiol. 1980 Jan;298:415-27. (PMID: 6987379) Neurosci Biobehav Rev. 2017 Dec;83:173-182. (PMID: 29054731) Aging Dis. 2015 Oct 01;6(5):331-41. (PMID: 26425388) Neurobiol Learn Mem. 2016 Dec;136:127-138. (PMID: 27720810) Cold Spring Harb Perspect Biol. 2015 Jun 01;7(6):. (PMID: 26032718) PLoS One. 2013 May 20;8(5):e62616. (PMID: 23700410) J Neurosci. 1996 Mar 15;16(6):2027-33. (PMID: 8604047) Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3256-3261. (PMID: 30718415) PLoS One. 2013 Sep 04;8(9):e72796. (PMID: 24023774) Lab Anim. 2007 Jan;41(1):111-9. (PMID: 17234057) Eur J Neurosci. 2011 May;33(9):1577-86. (PMID: 21395869) Adipocyte. 2015 Jul 15;5(1):11-21. (PMID: 27144092) Adv Nutr. 2017 Nov 15;8(6):804-811. (PMID: 29141966) Front Mol Neurosci. 2019 Feb 01;12:4. (PMID: 30774582) Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):765-72. (PMID: 12740124) J Neurosci. 2012 Mar 28;32(13):4610-22. (PMID: 22457507) J Affect Disord. 2017 Feb;209:209-216. (PMID: 27930914) Behav Brain Res. 2009 Jun 8;200(1):95-9. (PMID: 19162087) Am J Clin Nutr. 2005 Feb;81(2):341-54. (PMID: 15699220) Am J Clin Nutr. 2002 Jun;75(6):978-85. (PMID: 12036802) Mol Neurodegener. 2009 Dec 21;4:52. (PMID: 20025751) Neurosci Biobehav Rev. 2019 Dec;107:399-421. (PMID: 31454627) Synapse. 2015 Sep;69(9):421-33. (PMID: 26073877) Front Neurosci. 2019 May 22;13:508. (PMID: 31191220) Psychosom Med. 2015 Jul-Aug;77(6):697-709. (PMID: 26107577) J Neurochem. 2008 Jul;106(1):475-85. (PMID: 18410513) Exp Neurol. 2007 Mar;204(1):1-13. (PMID: 17258711) Eur J Neurosci. 2005 Jan;21(1):1-14. (PMID: 15654838) Cereb Cortex. 2015 Sep;25(9):3107-21. (PMID: 24860020) Eur J Pharmacol. 2003 Feb 28;463(1-3):3-33. (PMID: 12600700) Stem Cells. 2021 Oct;39(10):1362-1381. (PMID: 34043863) Neuroscience. 2005;132(3):613-24. (PMID: 15837123) Front Endocrinol (Lausanne). 2019 May 03;10:266. (PMID: 31130916) Behav Neurosci. 2011 Dec;125(6):943-55. (PMID: 22023100) Neuroscience. 2015 Jun 25;297:170-81. (PMID: 25849614) Handb Exp Pharmacol. 2014;220:223-50. (PMID: 24668475) Neuropharmacology. 2008 May;54(6):924-33. (PMID: 18384819) Neuropharmacology. 2017 May 1;117:316-327. (PMID: 28235548) J Neurosci. 2005 Sep 21;25(38):8680-5. (PMID: 16177036) Front Pharmacol. 2018 Apr 11;9:237. (PMID: 29695962) Growth Factors. 2004 Sep;22(3):123-31. (PMID: 15518235) Proc Nutr Soc. 2017 Nov;76(4):455-465. (PMID: 28514983) Arch Gen Psychiatry. 2006 Jul;63(7):824-30. (PMID: 16818872) Neuroscience. 2002;112(4):803-14. (PMID: 12088740) Curr Opin Psychiatry. 2010 Nov;23(6):504-9. (PMID: 20829694) PLoS One. 2015 May 29;10(5):e0128274. (PMID: 26023930) Int J Epidemiol. 2020 Aug 1;49(4):1353-1365. (PMID: 32575116) Neuropsychopharmacology. 2011 Aug;36(9):1823-36. (PMID: 21525862) J Alzheimers Dis. 2017;58(2):537-547. (PMID: 28453475) Behav Brain Res. 2015 Jun 1;286:265-70. (PMID: 25721737) J Neurochem. 2002 Sep;82(6):1367-75. (PMID: 12354284) |
معلومات مُعتمدة: | MB37-2017 Santa Casa da Misericórdia; IF/01227/2015 Fundação para a Ciência e Tecnologia |
فهرسة مساهمة: | Keywords: aging; brain-derived neurotrophic factor; high caloric diet; hippocampal plasticity; memory; neurogenesis; obesity |
المشرفين على المادة: | 0 (Biomarkers) |
تواريخ الأحداث: | Date Created: 20211223 Date Completed: 20220318 Latest Revision: 20220716 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8929079 |
DOI: | 10.3390/cimb43030162 |
PMID: | 34940136 |
قاعدة البيانات: | MEDLINE |
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