دورية أكاديمية
أعرض في EDS

Associations of Food Intolerance with Irritable Bowel Syndrome, Psychological Symptoms, and Quality of Life.

التفاصيل البيبلوغرافية
العنوان: Associations of Food Intolerance with Irritable Bowel Syndrome, Psychological Symptoms, and Quality of Life.
المؤلفون: Jansson-Knodell CL; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., White M; Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio., Lockett C; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Xu H; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana., Shin A; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: ashin@iu.edu.
المصدر: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2022 Sep; Vol. 20 (9), pp. 2121-2131.e3. Date of Electronic Publication: 2021 Dec 21.
نوع المنشور: Journal Article; Observational Study; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : W.B. Saunders for the American Gastroenterological Association, 2003-
مواضيع طبية MeSH: Irritable Bowel Syndrome* , Lactose Intolerance*, Adult ; Food Intolerance ; Humans ; Lactose ; Quality of Life ; Surveys and Questionnaires
مستخلص: Background & Aims: The impact of different types of food intolerance on gastrointestinal symptoms and quality of life (QOL) is poorly understood. We aimed to investigate associations of food intolerance and type of intolerance with irritable bowel syndrome (IBS), health-related QOL, and psychological symptoms.
Methods: We conducted an observational study of United States-based adults through an online survey. Demographics, culprit foods, symptoms, medical evaluation, Rome IV criteria for IBS, health-related QOL (Short-Form Health Survey 12), and anxiety and depression scores (Hospital Anxiety and Depression Scale) were collected in participants with self-reported food intolerance (lactose, non-lactose food, lactose plus food intolerance), and controls with no intolerance. Univariable associations of group with study endpoints were analyzed with the Kruskal-Wallis and Pearson χ 2 or Fisher exact test. Multivariable comparisons were analyzed by logistic and linear regression.
Results: A total of 197 patients with (59 lactose, 61 non-lactose food, 77 lactose plus food intolerance) and 273 patients without intolerance participated. Lactose, wheat, and eggs were the most common food triggers. Gas (54.2%), abdominal pain (40.2%), and diarrhea (37.3%) were frequently reported symptoms of food intolerance. Reactions caused 57.8% to eliminate the food. Rates of IBS, abnormal anxiety scores, and abnormal depression scores were highest in lactose plus food intolerance; Short-Form Health Survey 12 scores were lowest in lactose plus food intolerance. Multivariable analyses revealed all intolerance subgroups were more likely to have IBS than controls.
Conclusions: Food intolerance is associated with IBS, anxiety, depression, and decreased health-related QOL and frequently leads to food elimination. Adults with lactose and lactose plus food intolerance have higher rates of IBS, increased psychological symptoms, and poorer QOL.
(Copyright © 2022 AGA Institute. All rights reserved.)
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معلومات مُعتمدة: K23 DK122015 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Anxiety; Depression; Lactose Intolerance; Quality of Life; Survey
المشرفين على المادة: J2B2A4N98G (Lactose)
تواريخ الأحداث: Date Created: 20211224 Date Completed: 20220830 Latest Revision: 20230902
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9209586
DOI: 10.1016/j.cgh.2021.12.021
PMID: 34952206
قاعدة البيانات: MEDLINE
الوصف
تدمد:1542-7714
DOI:10.1016/j.cgh.2021.12.021