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Lipopolysaccharide Induces Gliotoxicity in Hippocampal Astrocytes from Aged Rats: Insights About the Glioprotective Roles of Resveratrol.

التفاصيل البيبلوغرافية
العنوان: Lipopolysaccharide Induces Gliotoxicity in Hippocampal Astrocytes from Aged Rats: Insights About the Glioprotective Roles of Resveratrol.
المؤلفون: Bobermin LD; Programa de Pós-Graduação Em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., de Souza Almeida RR; Programa de Pós-Graduação Em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Weber FB; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul- UFRGS, Rua Ramiro Barcelos, 2600 - Anexo Bairro Santa Cecília, Porto Alegre, RS, Brazil., Medeiros LS; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul- UFRGS, Rua Ramiro Barcelos, 2600 - Anexo Bairro Santa Cecília, Porto Alegre, RS, Brazil., Medeiros L; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul- UFRGS, Rua Ramiro Barcelos, 2600 - Anexo Bairro Santa Cecília, Porto Alegre, RS, Brazil., Wyse ATS; Programa de Pós-Graduação Em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul- UFRGS, Rua Ramiro Barcelos, 2600 - Anexo Bairro Santa Cecília, Porto Alegre, RS, Brazil., Gonçalves CA; Programa de Pós-Graduação Em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul- UFRGS, Rua Ramiro Barcelos, 2600 - Anexo Bairro Santa Cecília, Porto Alegre, RS, Brazil., Quincozes-Santos A; Programa de Pós-Graduação Em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil. andrequincozes@ufrgs.br.; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul- UFRGS, Rua Ramiro Barcelos, 2600 - Anexo Bairro Santa Cecília, Porto Alegre, RS, Brazil. andrequincozes@ufrgs.br.
المصدر: Molecular neurobiology [Mol Neurobiol] 2022 Mar; Vol. 59 (3), pp. 1419-1439. Date of Electronic Publication: 2022 Jan 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Clifton, NJ : Humana Press, c1987-
مواضيع طبية MeSH: Astrocytes*/metabolism , Lipopolysaccharides*/pharmacology, Animals ; Cells, Cultured ; Hippocampus/metabolism ; Inflammation/metabolism ; Rats ; Rats, Wistar ; Resveratrol/pharmacology
مستخلص: Astrocytes may undergo a functional remodeling with aging, acquiring a pro-inflammatory state. In line with this, resveratrol represents an interesting strategy for a healthier brain aging since it can improve glial functions. In the present study, we investigated the glioprotective role of resveratrol against lipopolysaccharide (LPS)-induced gliotoxicity in hippocampal aged astrocytes. Astrocyte cultures were obtained from aged rats (365 days old) and challenged in vitro with LPS in the presence of resveratrol. Cultured astrocytes from newborn rats were used as an age comparative for evaluating LPS gliotoxicity. In addition, aged rats were submitted to an acute systemic inflammation with LPS. Hippocampal astrocyte cultures were also obtained from these LPS-stimulated aged animals to further investigate the glioprotective effects of resveratrol in vitro. Overall, our results show that LPS induced a higher inflammatory response in aged astrocytes, compared to newborn astrocytes. Several inflammatory and gene expression alterations promoted by LPS in aged astrocyte cultures were similar in hippocampal tissue from aged animals submitted to in vivo LPS injection, corroborating our in vitro findings. Resveratrol, in turn, presented anti-inflammatory effects in aged astrocyte cultures, which were associated with downregulation of p21 and pro-inflammatory cytokines, Toll-like receptors (TLRs), and nuclear factor κB (NFκB). Resveratrol also improved astroglial functions. Upregulation of sirtuin 1 (SIRT1), nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase 1 (HO-1) represent potential molecular mechanisms associated with resveratrol-mediated glioprotection. In summary, our data show that resveratrol can prime aged astrocytes against gliotoxic stimuli, contributing to a healthier brain aging.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Aging; Astrocytes; Glioprotection; Gliotoxicity; Inflammation; Resveratrol
المشرفين على المادة: 0 (Lipopolysaccharides)
Q369O8926L (Resveratrol)
تواريخ الأحداث: Date Created: 20220107 Date Completed: 20220407 Latest Revision: 20220621
رمز التحديث: 20240829
DOI: 10.1007/s12035-021-02664-8
PMID: 34993844
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-1182
DOI:10.1007/s12035-021-02664-8