دورية أكاديمية
Clinical, Methodological, and Practical Considerations for Algorithmic Testing in Autoimmune Serology.
| العنوان: | Clinical, Methodological, and Practical Considerations for Algorithmic Testing in Autoimmune Serology. |
|---|---|
| المؤلفون: | Sepiashvili L; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.; SickKids Research Institute, Toronto, ON, Canada., Kenyon SM; Department of Laboratory Medicine, Geisinger Health, Danville, PA, USA. |
| المصدر: | The journal of applied laboratory medicine [J Appl Lab Med] 2022 Jan 05; Vol. 7 (1), pp. 268-280. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101693884 Publication Model: Print Cited Medium: Print ISSN: 2576-9456 (Print) Linking ISSN: 24757241 NLM ISO Abbreviation: J Appl Lab Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : Oxford : Oxford University Press Original Publication: [Washington, DC] : American Association for Clinical Chemistry, [2016]-[2019] |
| مواضيع طبية MeSH: | Autoimmune Diseases*/diagnosis , Rheumatic Diseases*, Antibodies, Antinuclear ; Autoantibodies ; Humans ; Laboratories, Clinical |
| مستخلص: | Background: Autoimmune serology tests are central to the classification, screening, diagnosis, and monitoring of a variety of autoimmune disorders. To improve the appropriateness of serologic evaluation and support laboratory resource utilization, reflex testing approaches have been proposed and implemented across clinical laboratories. Reflex testing involves a staged approach where an initial test result triggers subsequent tests based on prespecified rules. Content: Various reflex testing approaches in the context of antinuclear antibody-associated rheumatic disease, antineutrophil cytoplasmic autoantibody-associated vasculitis, celiac disease, and myasthenia gravis are reviewed here. Clinical, analytical, and practical considerations of reflex testing implementation are addressed as well as associated limitations and challenges. Summary: Serology reflex testing algorithms for the evaluation of autoimmune diseases can support clinical diagnosis and laboratory resource use but may be challenging to implement and are often applied variably across institutions. Assessments of evidence-driven guidelines, clinical impact, and impact on laboratory workflow are essential to this task. (© American Association for Clinical Chemistry 2022. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: ANA; ANCA; autoimmune serology; celiac disease; myasthenia gravis; reflex testing |
| المشرفين على المادة: | 0 (Antibodies, Antinuclear) 0 (Autoantibodies) |
| تواريخ الأحداث: | Date Created: 20220107 Date Completed: 20220128 Latest Revision: 20220531 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/jalm/jfab121 |
| PMID: | 34996074 |
| قاعدة البيانات: | MEDLINE |
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