دورية أكاديمية
أعرض في EDS

Rapid Determination of the 'Legal Highs' 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy.

التفاصيل البيبلوغرافية
العنوان: Rapid Determination of the 'Legal Highs' 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy.
المؤلفون: González-Hernández J; Centro de Investigación en Electroquímica y Energía Química (CELEQ), Universidad de Costa Rica, San José 11501-2060, Costa Rica.; Escuela de Química, Universidad de Costa Rica, San José 11501-2060, Costa Rica., Ott CE; Department of Forensic and Investigative Science, West Virginia University, Morgantown, WV 26506, USA., Arcos-Martínez MJ; Departamento de Química, Universidad de Burgos, Pza. Misael Bañuelos s/n, E-09001 Burgos, Spain., Colina Á; Departamento de Química, Universidad de Burgos, Pza. Misael Bañuelos s/n, E-09001 Burgos, Spain., Heras A; Departamento de Química, Universidad de Burgos, Pza. Misael Bañuelos s/n, E-09001 Burgos, Spain., Alvarado-Gámez AL; Centro de Investigación en Electroquímica y Energía Química (CELEQ), Universidad de Costa Rica, San José 11501-2060, Costa Rica., Urcuyo R; Centro de Investigación en Electroquímica y Energía Química (CELEQ), Universidad de Costa Rica, San José 11501-2060, Costa Rica.; Escuela de Química, Universidad de Costa Rica, San José 11501-2060, Costa Rica.; Centro de Investigación en Ciencias e Ingeniería de Materiales (CICIMA), Universidad de Costa Rica, San José 11501-2060, Costa Rica., Arroyo-Mora LE; Department of Forensic and Investigative Science, West Virginia University, Morgantown, WV 26506, USA.
المصدر: Sensors (Basel, Switzerland) [Sensors (Basel)] 2021 Dec 31; Vol. 22 (1). Date of Electronic Publication: 2021 Dec 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101204366 Publication Model: Electronic Cited Medium: Internet ISSN: 1424-8220 (Electronic) Linking ISSN: 14248220 NLM ISO Abbreviation: Sensors (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c2000-
مواضيع طبية MeSH: Gold* , Spectrum Analysis, Raman*, Electrodes ; Reproducibility of Results
مستخلص: The synthetic cathinones mephedrone (4-MMC) and 4-methylethcathinone (4-MEC) are two designer drugs that represent the rise and fall effect of this drug category within the stimulants market and are still available in several countries around the world. As a result, the qualitative and quantitative determination of 'legal highs', and their mixtures, are of great interest. This work explores for the first time the spectroelectrochemical response of these substances by coupling cyclic voltammetry (CV) with Raman spectroscopy in a portable instrument. It was found that the stimulants exhibit a voltammetric response on a gold screen-printed electrode while the surface is simultaneously electro-activated to achieve a periodic surface-enhanced Raman spectroscopy (SERS) substrate with high reproducibility. The proposed method enables a rapid and reliable determination in which both substances can be selectively analyzed through the oxidation waves of the molecules and the characteristic bands of the electrochemical SERS (EC-SERS) spectra. The feasibility and applicability of the method were assessed in simulated seized drug samples and spiked synthetic urine. This time-resolved spectroelectrochemical technique provides a cost-effective and user-friendly tool for onsite screening of synthetic stimulants in matrices with low concentration analytes for forensic applications.
References: Nanomaterials (Basel). 2020 Apr 17;10(4):. (PMID: 32316451)
Sensors (Basel). 2015 Jan 22;15(2):2232-43. (PMID: 25621602)
Talanta. 2020 Jan 1;206:120190. (PMID: 31514825)
Front Pharmacol. 2020 Jan 28;10:1588. (PMID: 32063845)
Anal Chem. 2013 Jan 15;85(2):923-31. (PMID: 23198960)
Analyst. 2020 Mar 2;145(5):1849-1857. (PMID: 31967120)
Chem Cent J. 2015 Jul 01;9:41. (PMID: 26155306)
J Colloid Interface Sci. 2013 Nov 15;410:74-80. (PMID: 23998370)
Front Chem. 2019 Oct 25;7:706. (PMID: 31709234)
Anal Chem. 2010 Nov 15;82(22):9299-305. (PMID: 20977219)
Analyst. 2020 Feb 17;145(4):1396-1407. (PMID: 32016204)
Anal Chem. 2012 Feb 7;84(3):1760-4. (PMID: 22242894)
Sensors (Basel). 2017 Nov 21;17(11):. (PMID: 29160798)
Biosensors (Basel). 2019 Apr 17;9(2):. (PMID: 30999661)
Br J Pharmacol. 2013 Jan;168(2):458-70. (PMID: 22897747)
Anal Chem. 2019 Mar 5;91(5):3747-3753. (PMID: 30773004)
Analyst. 2016 Feb 7;141(3):902-9. (PMID: 26779571)
J Anal Toxicol. 2017 Mar 1;41(2):100-106. (PMID: 27798075)
Chem Soc Rev. 2008 May;37(5):1025-41. (PMID: 18443687)
Bioorg Med Chem Lett. 2010 Jul 15;20(14):4135-9. (PMID: 20542690)
Anal Chim Acta. 2012 Jan 20;711:1-6. (PMID: 22152788)
Analyst. 2014 Jan 21;139(2):389-400. (PMID: 24287637)
Sci Rep. 2015 May 14;5:10208. (PMID: 25974125)
BMJ Open. 2012 Jul 31;2(4):. (PMID: 22855623)
Rev Sci Instrum. 2007 Jan;78(1):013705. (PMID: 17503926)
Nanomaterials (Basel). 2013 Mar 01;3(1):158-172. (PMID: 28348328)
Anal Chim Acta. 2022 May 29;1209:339250. (PMID: 35569862)
Phys Chem Chem Phys. 2009 Sep 14;11(34):7469-75. (PMID: 19690721)
Chem Sci. 2016 Mar 1;7(3):2364-2370. (PMID: 29997780)
Anal Chem. 2016 Apr 19;88(8):4487-94. (PMID: 26905258)
Biosensors (Basel). 2020 Oct 31;10(11):. (PMID: 33142781)
Chem Commun (Camb). 2017 May 4;53(37):5121-5124. (PMID: 28435951)
Sci Rep. 2019 Sep 3;9(1):12701. (PMID: 31481686)
Front Chem. 2021 May 07;9:664134. (PMID: 34026727)
Drug Test Anal. 2014 Jul-Aug;6(7-8):651-7. (PMID: 23900999)
Chem Cent J. 2016 Feb 01;10:3. (PMID: 26839583)
Anal Chem. 2015 Jan 6;87(1):441-7. (PMID: 25483146)
Forensic Sci Int Synerg. 2021 Feb 04;3:100129. (PMID: 33665591)
Talanta. 2017 Apr 1;165:384-390. (PMID: 28153271)
Food Chem. 2019 Mar 15;276:719-725. (PMID: 30409654)
ACS Sens. 2019 Apr 26;4(4):1109-1117. (PMID: 30907578)
معلومات مُعتمدة: 2019-DU-BX-0030 National Institute of Justice
فهرسة مساهمة: Keywords: 4-MEC; 4-MMC; Raman SERS; spectroelectrochemistry; synthetic cathinones
المشرفين على المادة: 7440-57-5 (Gold)
تواريخ الأحداث: Date Created: 20220111 Date Completed: 20220112 Latest Revision: 20240405
رمز التحديث: 20240405
مُعرف محوري في PubMed: PMC8749763
DOI: 10.3390/s22010295
PMID: 35009837
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-8220
DOI:10.3390/s22010295