دورية أكاديمية
Bacteriostatic and Cytotoxic Properties of Composite Material Based on ZnO Nanoparticles in PLGA Obtained by Low Temperature Method.
| العنوان: | Bacteriostatic and Cytotoxic Properties of Composite Material Based on ZnO Nanoparticles in PLGA Obtained by Low Temperature Method. |
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| المؤلفون: | Burmistrov DE; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia., Simakin AV; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia., Smirnova VV; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia., Uvarov OV; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia., Ivashkin PI; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia., Kucherov RN; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia.; Moscow Engineering Physics Institute, National Research Nuclear University MEPhI, Kashirskoe Highway 31, 115409 Moscow, Russia., Ivanov VE; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia.; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, 3 Institutskaya St., 142290 Pushchino, Russia., Bruskov VI; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, 3 Institutskaya St., 142290 Pushchino, Russia., Sevostyanov MA; A. A. Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences, Leninsky Prospect 49, 119991 Moscow, Russia., Baikin AS; A. A. Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences, Leninsky Prospect 49, 119991 Moscow, Russia., Kozlov VA; Faculty of Fundamental Sciences, Bauman Moscow State Technical University, Vtoraya Baumanskaya Ul. 5, 105005 Moscow, Russia., Rebezov MB; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia.; V. M. Gorbatov Federal Research Center for Food Systems of the Russian Academy of Sciences, 109316 Moscow, Russia., Semenova AA; V. M. Gorbatov Federal Research Center for Food Systems of the Russian Academy of Sciences, 109316 Moscow, Russia., Lisitsyn AB; V. M. Gorbatov Federal Research Center for Food Systems of the Russian Academy of Sciences, 109316 Moscow, Russia., Vedunova MV; Institute of Biology and Biomedicine, Lobachevsky State University of Nizhni Novgorod, 23 Prospekt Gagarina, 603950 Nizhny Novgorod, Russia., Gudkov SV; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia.; Institute of Biology and Biomedicine, Lobachevsky State University of Nizhni Novgorod, 23 Prospekt Gagarina, 603950 Nizhny Novgorod, Russia. |
| المصدر: | Polymers [Polymers (Basel)] 2021 Dec 23; Vol. 14 (1). Date of Electronic Publication: 2021 Dec 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101545357 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4360 (Electronic) Linking ISSN: 20734360 NLM ISO Abbreviation: Polymers (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel : MDPI |
| مستخلص: | A low-temperature technology was developed for producing a nanocomposite based on poly (lactic-co-glycolic acid) and zinc oxide nanoparticles (ZnO-NPs), synthesized by laser ablation. Nanocomposites were created containing 0.001, 0.01, and 0.1% of zinc oxide nanoparticles with rod-like morphology and a size of 40-70 nm. The surface of the films from the obtained nanomaterial was uniform, without significant defects. Clustering of ZnO-NPs in the PLGA matrix was noted, which increased with an increase in the concentration of the dopant in the polymer. The resulting nanomaterial was capable of generating reactive oxygen species (ROS), such as hydrogen peroxide and hydroxyl radicals. The rate of ROS generation increased with an increase in the concentration of the dopant. It was shown that the synthesized nanocomposite promotes the formation of long-lived reactive protein species, and is also the reason for the appearance of a key biomarker of oxidative stress, 8-oxoguanine, in DNA. The intensity of the process increased with an increase in the concentration of nanoparticles in the matrix. It was found that the nanocomposite exhibits significant bacteriostatic properties, the severity of which depends on the concentration of nanoparticles. In particular, on the surface of the PLGA-ZnO-NPs composite film containing 0.001% nanoparticles, the number of bacterial cells was 50% lower than that of pure PLGA. The surface of the composite is non-toxic to eukaryotic cells and does not interfere with their adhesion, growth, and division. Due to its low cytotoxicity and bacteriostatic properties, this nanocomposite can be used as coatings for packaging in the food industry, additives for textiles, and also as a material for biomedicine. |
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| معلومات مُعتمدة: | 075-15-2020-775 Ministry of Science and Higher Education of the Russian Federation |
| فهرسة مساهمة: | Keywords: PLGA; antibacterial; biocompatibility; composite; cytotoxicity; nanoparticles; poly(lactic-co-glycolic acid); zinc oxide |
| تواريخ الأحداث: | Date Created: 20220111 Latest Revision: 20231105 |
| رمز التحديث: | 20231105 |
| مُعرف محوري في PubMed: | PMC8747160 |
| DOI: | 10.3390/polym14010049 |
| PMID: | 35012071 |
| قاعدة البيانات: | MEDLINE |
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