دورية أكاديمية
Swimming exercise and diphenyl diselenide-supplemented diet modulate cerebral cortical and striatal GABA uptake in aged rats.
| العنوان: | Swimming exercise and diphenyl diselenide-supplemented diet modulate cerebral cortical and striatal GABA uptake in aged rats. |
|---|---|
| المؤلفون: | Pesarico AP; Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Departamento de Bioquímica e Biologia Molecular, Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Av. Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil., Cechella JL; Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Departamento de Bioquímica e Biologia Molecular, Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Av. Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil., Nogueira CW; Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Departamento de Bioquímica e Biologia Molecular, Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Av. Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil., Rosa SG; Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Departamento de Bioquímica e Biologia Molecular, Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Av. Roraima, 1000, Cidade Universitária, Camobi, 97105-900 Santa Maria, RS, Brazil. |
| المصدر: | Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2022 Jan 07; Vol. 94 (1), pp. e20200844. Date of Electronic Publication: 2022 Jan 07 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academia Brasileira De Ciencias Country of Publication: Brazil NLM ID: 7503280 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-2690 (Electronic) Linking ISSN: 00013765 NLM ISO Abbreviation: An Acad Bras Cienc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rio De Janeiro : Academia Brasileira De Ciencias |
| مواضيع طبية MeSH: | Dietary Supplements* , Swimming*, Animals ; Benzene Derivatives ; Cerebral Cortex ; Diet ; Male ; Organoselenium Compounds ; Rats ; Rats, Wistar ; gamma-Aminobutyric Acid |
| مستخلص: | Aging is characterized by several neurochemical modifications involving structural proteins and neurotransmitters. Exercise has been recognized as an enhancer of overall health; whereas, diphenyl diselenide (PhSe)2 has been reported to have antioxidant, anti-inflammatory, and neuroprotective effects in rodents. A combination of pharmacological and non-pharmacological interventions has been proposed to prevent the aging effects. This study aimed to determine the swimming exercise and (PhSe)2 dietary supplementation synergic effects on the [3H] γ-aminobutyric acid (GABA) uptake in aged rats. Male Wistar rats (24 months) received 1 ppm of (PhSe)2 supplemented in the standard chow for 4 weeks. Rats were subjected to swimming training (20 min per day for 4 weeks). After 4 weeks, the [3H]GABA uptake was determined in samples of cerebral cortex and striatum of rats. The results of the present study demonstrate that the association of (PhSe)2-supplemented diet and swimming exercise was effective against the decrease of cerebral cortical and striatal [3H]GABA uptake in aged rats. The association of (PhSe)2 dietary supplementation with swimming exercise modulated the GABA uptake in cerebral structures of aged rats. |
| المشرفين على المادة: | 0 (Benzene Derivatives) 0 (Organoselenium Compounds) 1666-13-3 (diphenyldiselenide) 56-12-2 (gamma-Aminobutyric Acid) |
| تواريخ الأحداث: | Date Created: 20220112 Date Completed: 20220113 Latest Revision: 20220113 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1590/0001-3765202220200844 |
| PMID: | 35019002 |
| قاعدة البيانات: | MEDLINE |
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