دورية أكاديمية
أعرض في EDS

Antibiotic Therapy in 2-Stage Revision for Periprosthetic Joint Infection: A Systematic Review.

التفاصيل البيبلوغرافية
العنوان: Antibiotic Therapy in 2-Stage Revision for Periprosthetic Joint Infection: A Systematic Review.
المؤلفون: Kurapatti M; Department of Orthopedic Surgery, NYU Langone Health, New York, NY., Oakley C, Singh V, Aggarwal VK
المصدر: JBJS reviews [JBJS Rev] 2022 Jan 12; Vol. 10 (1). Date of Electronic Publication: 2022 Jan 12.
نوع المنشور: Journal Article; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 101674872 Publication Model: Electronic Cited Medium: Internet ISSN: 2329-9185 (Electronic) Linking ISSN: 23299185 NLM ISO Abbreviation: JBJS Rev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2016- : Philadelphia : Wolters Kluwer
Original Publication: Needham, MA : Journal of Bone and Joint Surgery, Inc., [2013]-
مواضيع طبية MeSH: Arthritis, Infectious*/etiology , Arthroplasty, Replacement, Knee*/adverse effects , Prosthesis-Related Infections*/drug therapy , Prosthesis-Related Infections*/etiology , Prosthesis-Related Infections*/surgery, Anti-Bacterial Agents/therapeutic use ; Humans ; Retrospective Studies
مستخلص: Background: Patients undergoing total joint arthroplasty (TJA) are at risk for developing periprosthetic joint infection (PJI). To treat PJI, orthopaedic surgeons can perform 1-stage or 2-stage revision arthroplasty. Although 2-stage revision yields superior long-term outcomes, the optimal antibiotic therapy duration and route of administration between stages remain uncertain. In this systematic review, we aimed to identify if variations in antibiotic therapy, duration, and administration during 2-stage hip or knee revision arthroplasty affect PJI eradication rates and surgical outcome measures.
Methods: A literature search was performed using the PubMed and Google Scholar databases to identify all original reports from January 2000 to June 2021 involving 2-stage revision arthroplasty to treat PJI. Studies were included if they specified antibiotic duration, an intravenous (IV) route of antibiotic administration, type of antibiotic, and 2-stage revision PJI eradication rate and had a mean or median follow-up of at least 2 years after the second-stage operation. Included studies were classified into 3 groups based on the length of IV antibiotic therapy after prosthesis explantation: prolonged IV antibiotic therapy of 4 to 6 weeks, shortened IV antibiotic therapy of ≤2 weeks, and shortened course of IV antibiotic therapy followed by 6 to 12 weeks of oral antibiotics.
Results: Nine studies were included. Three studies utilizing a prolonged IV antibiotic therapy had PJI eradication rates of 79% to 96%. Four studies using a shortened IV antibiotic therapy showed PJI eradication rates of 88% to 100%. Finally, 2 studies utilizing a shortened course of IV antibiotic therapy with oral antibiotics had PJI eradication rates of 95% and 97%. There was no significant difference in eradication rates across IV antibiotic duration strategies, despite a diverse array of cultured microorganisms across the studies.
Conclusions: Although the numbers are small, this systematic review suggests that prolonged IV antibiotic duration, shortened IV antibiotic duration, and shortened IV antibiotic duration supplemented with oral antibiotics confer similar PJI eradication rates after hip or knee arthroplasty.
Level of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Competing Interests: Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSREV/A793).
(Copyright © 2022 by The Journal of Bone and Joint Surgery, Incorporated.)
References: Pulido L, Ghanem E, Joshi A, Purtill JJ, Parvizi J. Periprosthetic joint infection: the incidence, timing, and predisposing factors. Clin Orthop Relat Res. 2008 Jul;466(7):1710-5.
Gundtoft PH, Overgaard S, Schønheyder HC, Møller JK, Kjærsgaard-Andersen P, Pedersen AB. The “true” incidence of surgically treated deep prosthetic joint infection after 32,896 primary total hip arthroplasties: a prospective cohort study. Acta Orthop. 2015 Jun;86(3):326-34.
Huotari K, Peltola M, Jämsen E. The incidence of late prosthetic joint infections: a registry-based study of 112,708 primary hip and knee replacements. Acta Orthop. 2015 Jun;86(3):321-5.
Natsuhara KM, Shelton TJ, Meehan JP, Lum ZC. Mortality during total hip periprosthetic joint infection. J Arthroplasty. 2019 Jul;34(7S)(Supplement):S337-42.
Charette RS, Melnic CM. Two-stage revision arthroplasty for the treatment of prosthetic joint infection. Curr Rev Musculoskelet Med. 2018 Sep;11(3):332-40.
Insall JN, Thompson FM, Brause BD. Two-stage reimplantation for the salvage of infected total knee arthroplasty. J Bone Joint Surg Am. 1983 Oct;65(8):1087-98.
McDonald DJ, Fitzgerald RH Jr, Ilstrup DM. Two-stage reconstruction of a total hip arthroplasty because of infection. J Bone Joint Surg Am. 1989 Jul;71(6):828-34.
Hsieh PH, Huang KC, Lee PC, Lee MS. Two-stage revision of infected hip arthroplasty using an antibiotic-loaded spacer: retrospective comparison between short-term and prolonged antibiotic therapy. J Antimicrob Chemother. 2009 Aug;64(2):392-7.
Stockley I, Mockford BJ, Hoad-Reddick A, Norman P. The use of two-stage exchange arthroplasty with depot antibiotics in the absence of long-term antibiotic therapy in infected total hip replacement. J Bone Joint Surg Br. 2008 Feb;90(2):145-8.
Darley ESR, Bannister GC, Blom AW, Macgowan AP, Jacobson SK, Alfouzan W. Role of early intravenous to oral antibiotic switch therapy in the management of prosthetic hip infection treated with one- or two-stage replacement. J Antimicrob Chemother. 2011 Oct;66(10):2405-8.
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement. PLoS Med. 2009 Jul 21;6(7):e1000097.
Bejon P, Berendt A, Atkins BL, Green N, Parry H, Masters S, McLardy-Smith P, Gundle R, Byren I. Two-stage revision for prosthetic joint infection: predictors of outcome and the role of reimplantation microbiology. J Antimicrob Chemother. 2010 Mar;65(3):569-75.
Hart WJ, Jones RS. Two-stage revision of infected total knee replacements using articulating cement spacers and short-term antibiotic therapy. J Bone Joint Surg Br. 2006 Aug;88(8):1011-5.
Hoad-Reddick DA, Evans CR, Norman P, Stockley I. Is there a role for extended antibiotic therapy in a two-stage revision of the infected knee arthroplasty? J Bone Joint Surg Br. 2005 Feb;87(2):171-4.
Ibrahim MS, Raja S, Khan MA, Haddad FS. A multidisciplinary team approach to two-stage revision for the infected hip replacement: a minimum five-year follow-up study. Bone Joint J. 2014 Oct;96-B(10):1312-8.
Leung F, Richards CJ, Garbuz DS, Masri BA, Duncan CP. Two-stage total hip arthroplasty: how often does it control methicillin-resistant infection? Clin Orthop Relat Res. 2011 Apr;469(4):1009-15.
McKenna PB, O’Shea K, Masterson EL. Two-stage revision of infected hip arthroplasty using a shortened post-operative course of antibiotics. Arch Orthop Trauma Surg. 2009 Apr;129(4):489-94.
Oussedik SIS, Dodd MB, Haddad FS. Outcomes of revision total hip replacement for infection after grading according to a standard protocol. J Bone Joint Surg Br. 2010 Sep;92(9):1222-6.
Whittaker JP, Warren RE, Jones RS, Gregson PA. Is prolonged systemic antibiotic treatment essential in two-stage revision hip replacement for chronic Gram-positive infection? J Bone Joint Surg Br. 2009 Jan;91(1):44-51.
Akgün D, Müller M, Perka C, Winkler T. High cure rate of periprosthetic hip joint infection with multidisciplinary team approach using standardized two-stage exchange. J Orthop Surg Res. 2019 Mar 13;14(1):78.
Berend KR, Lombardi AV Jr, Morris MJ, Bergeson AG, Adams JB, Sneller MA. Two-stage treatment of hip periprosthetic joint infection is associated with a high rate of infection control but high mortality. Clin Orthop Relat Res. 2013 Feb;471(2):510-8.
Chen SY, Hu CC, Chen CC, Chang YH, Hsieh PH. Two-stage revision arthroplasty for periprosthetic hip infection: mean follow-up of ten years. Biomed Res Int. 2015;2015:345475.
Ford AN, Holzmeister AM, Rees HW, Belich PD. Characterization of outcomes of 2-stage exchange arthroplasty in the treatment of prosthetic joint infections. J Arthroplasty. 2018 Jul;33(7S)(Supplement):S224-7.
Lichstein P, Su S, Hedlund H, Suh G, Maloney WJ, Goodman SB, Huddleston JI 3rd. Treatment of periprosthetic knee infection with a two-stage protocol using static spacers. Clin Orthop Relat Res. 2016 Jan;474(1):120-5.
Lim SJ, Park JC, Moon YW, Park YS. Treatment of periprosthetic hip infection caused by resistant microorganisms using 2-stage reimplantation protocol. J Arthroplasty. 2009 Dec;24(8):1264-9.
Mahmud T, Lyons MC, Naudie DD, Macdonald SJ, McCalden RW. Assessing the gold standard: a review of 253 two-stage revisions for infected TKA. Clin Orthop Relat Res. 2012 Oct;470(10):2730-6.
Masri BA, Panagiotopoulos KP, Greidanus NV, Garbuz DS, Duncan CP. Cementless two-stage exchange arthroplasty for infection after total hip arthroplasty. J Arthroplasty. 2007 Jan;22(1):72-8.
Mortazavi SMJ, Vegari D, Ho A, Zmistowski B, Parvizi J. Two-stage exchange arthroplasty for infected total knee arthroplasty: predictors of failure. Clin Orthop Relat Res. 2011 Nov;469(11):3049-54.
Thaler M, Lechner R, Dammerer D, Leitner H, Khosravi I, Nogler M. The direct anterior approach: treating periprosthetic joint infection of the hip using two-stage revision arthroplasty. Arch Orthop Trauma Surg. 2020 Feb;140(2):255-62.
Vielgut I, Schwantzer G, Leithner A, Sadoghi P, Berzins U, Glehr M. Successful two-stage exchange arthroplasty for periprosthetic infection following total knee arthroplasty: the impact of timing on eradication of infection. Int J Med Sci. 2021 Jan 1;18(4):1000-6.
Winkler T, Stuhlert MGW, Lieb E, Müller M, von Roth P, Preininger B, Trampuz A, Perka CF. Outcome of short versus long interval in two-stage exchange for periprosthetic joint infection: a prospective cohort study. Arch Orthop Trauma Surg. 2019 Mar;139(3):295-303.
Postler A, Lützner C, Beyer F, Tille E, Lützner J. Analysis of total knee arthroplasty revision causes. BMC Musculoskelet Disord. 2018 Feb 14;19(1):55.
Karachalios T, Komnos G, Koutalos A. Total hip arthroplasty: survival and modes of failure. EFORT Open Rev. 2018 May 21;3(5):232-9.
Springer BD, Cahue S, Etkin CD, Lewallen DG, McGrory BJ. Infection burden in total hip and knee arthroplasties: an international registry-based perspective. Arthroplast Today. 2017 Jun 20;3(2):137-40.
Nelson CL, Evans RP, Blaha JD, Calhoun J, Henry SL, Patzakis MJ. A comparison of gentamicin-impregnated polymethylmethacrylate bead implantation to conventional parenteral antibiotic therapy in infected total hip and knee arthroplasty. Clin Orthop Relat Res. 1993 Oct;(295):96-101.
Malhas AM, Lawton R, Reidy M, Nathwani D, Clift BA. Causative organisms in revision total hip & knee arthroplasty for infection: increasing multi-antibiotic resistance in coagulase-negative Staphylococcus and the implications for antibiotic prophylaxis. Surgeon. 2015 Oct;13(5):250-5.
Wintenberger C, Guery B, Bonnet E, Castan B, Cohen R, Diamantis S, Lesprit P, Maulin L, Péan Y, Peju E, Piroth L, Stahl JP, Strady C, Varon E, Vuotto F, Gauzit R; Recommendation Group of the SPILF. Proposal for shorter antibiotic therapies. Med Mal Infect. 2017 Mar;47(2):92-141.
Kuzyk PRT, Dhotar HS, Sternheim A, Gross AE, Safir O, Backstein D. Two-stage revision arthroplasty for management of chronic periprosthetic hip and knee infection: techniques, controversies, and outcomes. J Am Acad Orthop Surg. 2014 Mar;22(3):153-64.
Smilack JD, Flittie WH, Williams TW Jr. Bone concentrations of antimicrobial agents after parenteral administration. Antimicrob Agents Chemother. 1976 Jan;9(1):169-71.
Eijer H, de Beaubien B, Stockley I, Kratky A, Kessler B, Martin KE, Ferry C, Petrie MJ, Bell K. Part II. Hip and knee. Section 5.10. Treatment: antimicrobials (two-stage). Question 4: can short term (two weeks or less) antibiotic treatment be considered following resection arthroplasty for chronic periprosthetic joint infections (PJIs)? Int Consens Meet. 2018;5(10):500-501.
Nodzo SR, Murillo O, Lachiewicz A, Boyle K, O’Callaghan M. Part II. Hip and knee. Section 5.10. Treatment: antimicrobials (two-stage). Question 1: (A) What is optimal length of administration for antibiotic treatment following resection arthroplasty? (B) What is the optimal mode of administration for antibiotic treatment following resection arthroplasty? Int Consens Meet. 2018;5(10):496-7.
Diaz-Ledezma C, Higuera CA, Parvizi J. Success after treatment of periprosthetic joint infection: a Delphi-based international multidisciplinary consensus. Clin Orthop Relat Res. 2013 Jul;471(7):2374-82.
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20220112 Date Completed: 20220331 Latest Revision: 20230920
رمز التحديث: 20240829
DOI: e21.00143
PMID: 35020709
قاعدة البيانات: MEDLINE
الوصف
تدمد:2329-9185
DOI:e21.00143