دورية أكاديمية
أعرض في EDS

Diminazene Aceturate, an angiotensin converting enzyme 2 (ACE2) activator, promotes cardioprotection in ischemia/reperfusion-induced cardiac injury.

التفاصيل البيبلوغرافية
العنوان: Diminazene Aceturate, an angiotensin converting enzyme 2 (ACE2) activator, promotes cardioprotection in ischemia/reperfusion-induced cardiac injury.
المؤلفون: Coutinho DCO; Department of Morphology, Federal University of Minas Gerais, Brazil. Electronic address: daniellecocoutinho@gmail.com., Santos-Miranda A; Laboratory of CardioBiology, Department of Biophysics, Federal University of Sao Paulo, Brazil., Joviano-Santos JV; Laboratory of CardioBiology, Department of Biophysics, Federal University of Sao Paulo, Brazil., Foureaux G; Department of Morphology, Federal University of Minas Gerais, Brazil., Santos A; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Brazil., Rodrigues-Ferreira C; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Martins-Júnior PA; Department of Child and Adolescent Oral Health, Federal University of Minas Gerais, Brazil., Resende RR; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Brazil., Medei E; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Vieyra A; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Santos RAS; Department of Physiology and Biophysics, Federal University of Minas Gerais, Brazil; National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Brazil., Cruz JS; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Brazil., Ferreira AJ; Department of Morphology, Federal University of Minas Gerais, Brazil. Electronic address: andersonicb@gmail.com.
المصدر: Peptides [Peptides] 2022 May; Vol. 151, pp. 170746. Date of Electronic Publication: 2022 Jan 13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 8008690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5169 (Electronic) Linking ISSN: 01969781 NLM ISO Abbreviation: Peptides Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier Science Inc.
Original Publication: Fayetteville, N. Y., Ankho International.
مواضيع طبية MeSH: Angiotensin-Converting Enzyme 2* , Reperfusion Injury*, Adenosine Triphosphate ; Animals ; Arrhythmias, Cardiac ; Diminazene/analogs & derivatives ; Myocytes, Cardiac ; Peptidyl-Dipeptidase A ; Rats ; Rats, Wistar ; Reperfusion
مستخلص: This study aimed to investigate whether the Diminazene Aceturate (DIZE), an angiotensin-converting enzyme 2 (ACE2) activator, can revert cardiac dysfunction in ischemia reperfusion-induced (I/R) injury in animals and examine the mechanism underlying this effect. Wistar rats systemically received DIZE (1 mg/kg) for thirty days. Cardiac function in isolated rat hearts was evaluated using the Langendorff technique. After I/R, ventricular non-I/R and I/R samples were used to evaluate ATP levels. Mitochondrial function was assessed using cardiac permeabilized fibers and isolated cardiac mitochondria. Cardiac cellular electrophysiology was evaluated using the patch clamp technique. DIZE protected the heart after I/R from arrhythmia and cardiac dysfunction by preserving ATP levels, independently of any change in coronary flow and heart rate. DIZE improved mitochondrial function, increasing the capacity for generating ATP and reducing proton leak without changing the specific citrate synthase activity. The activation of the ACE2 remodeled cardiac electrical profiles, shortening the cardiac action potential duration at 90 % repolarization. Additionally, cardiomyocytes from DIZE-treated animals exhibited reduced sensibility to diazoxide (K ATP agonist) and a higher K ATP current compared to the controls. DIZE was able to improve mitochondrial function and modulate cardiac electrical variables with a cardio-protective profile, resulting in direct myocardial cell protection from I/R injury.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Angiotensin converting enzyme; Arrhythmia; Diminazene Aceturate; Ischemia reperfusion injury; Mitochondria
المشرفين على المادة: 8L70Q75FXE (Adenosine Triphosphate)
EC 3.4.15.1 (Peptidyl-Dipeptidase A)
EC 3.4.17.23 (Angiotensin-Converting Enzyme 2)
JI8SAD85NO (diminazene aceturate)
Y5G36EEA5Z (Diminazene)
تواريخ الأحداث: Date Created: 20220116 Date Completed: 20220413 Latest Revision: 20220413
رمز التحديث: 20221213
DOI: 10.1016/j.peptides.2022.170746
PMID: 35033621
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-5169
DOI:10.1016/j.peptides.2022.170746