دورية أكاديمية
أعرض في EDS

Overexpression of IL-8 and Wnt2 is associated with prognosis of gastric cancer.

التفاصيل البيبلوغرافية
العنوان: Overexpression of IL-8 and Wnt2 is associated with prognosis of gastric cancer.
المؤلفون: Lin L; Department of Hematology & Oncology, Gansu provincial maternity and child-care hospital, Lanzhou, Gansu 730050, P. R. China. gs_linli@163.com., Li L; Department of Clinical Laboratory Center, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China., Ma G; Department of Pathology, Gansu Provincial Cancer Hospital, Lanzhou, Gansu 730050, P.R. China., Kang Y; Department of Pathology, Gansu Provincial Cancer Hospital, Lanzhou, Gansu 730050, P.R. China., Wang X; Department of Interventional therapy, Gansu Provincial Cancer Hospital, Lanzhou, Gansu 730050, P. R. China., He J; Basic Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P. R. China.
المصدر: Folia histochemica et cytobiologica [Folia Histochem Cytobiol] 2022; Vol. 60 (1), pp. 66-73. Date of Electronic Publication: 2022 Jan 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Polish Histochemical and Cytochemical Society at VM Media Country of Publication: Poland NLM ID: 8502651 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1897-5631 (Electronic) Linking ISSN: 02398508 NLM ISO Abbreviation: Folia Histochem Cytobiol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2011-> : Gdańsk : Polish Histochemical and Cytochemical Society at VM Media
Original Publication: Warszawa : Polish Scientific Publishers, 1984-
مواضيع طبية MeSH: Interleukin-8/*metabolism , Stomach Neoplasms/*pathology , Wnt2 Protein/*metabolism, Biomarkers, Tumor/metabolism ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Neoplasm Staging ; Prognosis ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/mortality ; Wnt2 Protein/genetics
مستخلص: Introduction: This study is to detect the expression of inflammatory factor or neutrophil-activating factor IL-8 and Wnt2 in gastric cancer (GC) and investigate the involvement of IL-8 and Wnt2 expressions in the clinicopathological indexes and prognosis.
Material and Methods: We detected the expression of IL-8 and Wnt2 in 100 GC tissues and 40 normal gastric mucosae using immunohistochemistry. The relationships between the IL-8 and Wnt2 expression and the clinicopathological characteristics were explored. The relationship between IL-8 expression, Wnt2 expression, and prognosis of GC was analyzed by survival curve and survival regression.
Results: The expression of IL-8 and Wnt2 in GC tissue was 64% and 75% respectively, which was significantly higher than that in adjacent normal gastric mucosa tissues, moreover, expressions of IL-8 and Wnt2 were positively correlated. The positive rate of IL-8 and Wnt2 expressions were correlated with lymph node metastasis and TNM staging （P < 0.01, and Wnt2 was also correlated with infiltration depth (P = 0.021), but there was no difference with age, sex, and differentiation (P > 0.05). The 3-year survival analysis showed that the survival rates of IL-8- and Wnt2-positive patients were 20% and 24%, respectively, which were significantly lower than those of negative patients. Cox regression analysis showed that IL-8 and Wnt2 may be independent factors affecting the prognosis of GC.
Conclusions: Our data demonstrated that the overexpression of IL-8 and Wnt2 could be isolated prognostic factors in patients with GC and, possibly, may present new targets for the treatment of GC.
فهرسة مساهمة: Keywords: IHC; Wnt2; gastric cancer; interleukin-8; prognosis
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (Interleukin-8)
0 (WNT2 protein, human)
0 (Wnt2 Protein)
تواريخ الأحداث: Date Created: 20220117 Date Completed: 20220322 Latest Revision: 20220531
رمز التحديث: 20231215
DOI: 10.5603/FHC.a2022.0002
PMID: 35037695
قاعدة البيانات: MEDLINE
الوصف
تدمد:1897-5631
DOI:10.5603/FHC.a2022.0002