تقرير
أعرض في EDS

Low-Dose Baclofen-Induced Encephalopathy in a Healthy Young Adult: Is Baclofen Toxicity Dose-Dependent?

التفاصيل البيبلوغرافية
العنوان: Low-Dose Baclofen-Induced Encephalopathy in a Healthy Young Adult: Is Baclofen Toxicity Dose-Dependent?
المؤلفون: Ibeson E; Internal Medicine, Maimonides Medical Center, Brooklyn, USA., Nwosu I; Internal Medicine, Maimonides Medical Center, Brooklyn, USA., Donenfeld T; Internal Medicine, Maimonides Medical Center, Brooklyn, USA., Clemen B; Internal Medicine, Maimonides Medical Center, Brooklyn, USA., Ogar UA; Internal Medicine, Peterborough City Hospital, Peterborough, GBR., Ogbeifun OE; Public Health, University of West Florida, Pensacola, USA., Marcelin M; Internal Medicine, Maimonides Medical Center, Brooklyn, USA.
المصدر: Cureus [Cureus] 2021 Dec 18; Vol. 13 (12), pp. e20499. Date of Electronic Publication: 2021 Dec 18 (Print Publication: 2021).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Baclofen is a commonly used medication for managing muscle spasticity with the potential of causing life-threatening adverse effects, including encephalopathy as well as withdrawal symptoms including confusion and hallucinations following abrupt discontinuation. Severe toxicity with baclofen is common in patients with kidney disease, hence the importance of dose reduction and monitoring in patients with renal impairment. This article reports a case of encephalopathy with low-dose baclofen in an otherwise healthy young adult concurrently taking ibuprofen and baclofen and aims to underscore the importance of potential drug interaction and patient education when initiating baclofen.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2021, Ibeson et al.)
References: Am J Kidney Dis. 2018 Feb;71(2):275-280. (PMID: 28899601)
Am J Case Rep. 2015 Apr 20;16:232-5. (PMID: 25895118)
J Clin Neurophysiol. 2019 May;36(3):209-212. (PMID: 30688773)
Arch Neurol. 1988 Jul;45(7):814-5. (PMID: 3390037)
Ann Pharmacother. 2006 Nov;40(11):2071-3. (PMID: 17047139)
Drug Intell Clin Pharm. 1984 Oct;18(10):805-8. (PMID: 6489161)
Ann Neurol. 1985 Jun;17(6):617-8. (PMID: 4026235)
SAGE Open Med. 2021 Jun 3;9:20503121211022197. (PMID: 34158937)
World Neurosurg. 2020 Apr;136:136-139. (PMID: 31954899)
Ther Adv Drug Saf. 2017 May;8(5):165-167. (PMID: 28588762)
Ital J Neurol Sci. 1991 Jun;12(3):323-5. (PMID: 1874611)
Postgrad Med J. 2020 Dec;96(1142):780-781. (PMID: 32114492)
Emerg Med Australas. 2006 Feb;18(1):77-82. (PMID: 16454779)
فهرسة مساهمة: Keywords: baclofen toxicity; drug interaction; encephalopathy; nsaids; renal impairment
تواريخ الأحداث: Date Created: 20220120 Latest Revision: 20220121
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8760001
DOI: 10.7759/cureus.20499
PMID: 35047311
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.20499