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Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats.

التفاصيل البيبلوغرافية
العنوان: Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats.
المؤلفون: Carvalho AVS; Post-Graduation Program of Neuroscience, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, Brazil., Ribeiro RT; Post-Graduation Program of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil., Durán-Carabali LE; Post-Graduation Program of Physiology, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050-170, Brazil., Martini APR; Post-Graduation Program of Neuroscience, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, Brazil., Hoeper E; Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil., Sanches EF; Post-Graduation Program of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil., Konrath EL; Department of Pharmaceutical Sciences, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil., Dalmaz C; Post-Graduation Program of Neuroscience, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, Brazil.; Post-Graduation Program of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil.; Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil., Wajner M; Post-Graduation Program of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil.; Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil., Netto CA; Post-Graduation Program of Neuroscience, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, Brazil.; Post-Graduation Program of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil.; Post-Graduation Program of Physiology, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050-170, Brazil.; Department of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, Brazil.
المصدر: Nutrients [Nutrients] 2022 Jan 17; Vol. 14 (2). Date of Electronic Publication: 2022 Jan 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Neuroprotective Agents*, Hypoxia-Ischemia, Brain/*drug therapy , Myrtaceae/*chemistry , Neuroinflammatory Diseases/*prevention & control , Plant Extracts/*administration & dosage, Animals ; Animals, Newborn ; Behavior, Animal/drug effects ; Brain/drug effects ; Brain/pathology ; Brain/physiopathology ; Fruit/chemistry ; Glutathione Peroxidase/metabolism ; Hypoxia-Ischemia, Brain/complications ; Hypoxia-Ischemia, Brain/physiopathology ; Lipid Peroxidation/drug effects ; Male ; Neurons/pathology ; Oxidation-Reduction/drug effects ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar
مستخلص: The disruption of redox homeostasis and neuroinflammation are key mechanisms in the pathogenesis of brain hypoxia-ischemia (HI); medicinal plants have been studied as a therapeutic strategy, generally associated with the prevention of oxidative stress and inflammatory response. This study evaluates the neuroprotective role of the Plinia trunciflora fruit extract (PTE) in neonatal rats submitted to experimental HI. The HI insult provoked a marked increase in the lipoperoxidation levels and glutathione peroxidase (GPx) activity, accompanied by a decrease in the brain concentration of glutathione (GSH). Interestingly, PTE was able to prevent most of the HI-induced pro-oxidant effects. It was also observed that HI increased the levels of interleukin-1β in the hippocampus, and that PTE-treatment prevented this effect. Furthermore, PTE was able to prevent neuronal loss and astrocyte reactivity induced by HI, as demonstrated by NeuN and GFAP staining, respectively. PTE also attenuated the anxiety-like behavior and prevented the spatial memory impairment caused by HI. Finally, PTE prevented neural tissue loss in the brain hemisphere, the hippocampus, cerebral cortex, and the striatum ipsilateral to the HI. Taken together our results provide good evidence that the PTE extract has the potential to be investigated as an adjunctive therapy in the treatment of brain insult caused by neonatal hypoxia-ischemia.
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فهرسة مساهمة: Keywords: Plinia trunciflora extract (PTE); antioxidants; hypoxia–ischemia (HI); medicinal plants; neuroprotection; spatial memory
المشرفين على المادة: 0 (Neuroprotective Agents)
0 (Plant Extracts)
EC 1.11.1.9 (Glutathione Peroxidase)
تواريخ الأحداث: Date Created: 20220121 Date Completed: 20220127 Latest Revision: 20220128
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8779767
DOI: 10.3390/nu14020395
PMID: 35057576
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu14020395