Ophiorrhines F and G, Key Biogenetic Intermediates of Ophiorrhine Alkaloids from Ophiorrhiza japonica and Their Immunosuppressant Activities.

التفاصيل البيبلوغرافية
العنوان:	Ophiorrhines F and G, Key Biogenetic Intermediates of Ophiorrhine Alkaloids from Ophiorrhiza japonica and Their Immunosuppressant Activities.
المؤلفون:	Shi BB; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China., Ai HL; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China., Duan KT; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China., Feng T; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China., Liu JK; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
المصدر:	Journal of natural products [J Nat Prod] 2022 Feb 25; Vol. 85 (2), pp. 453-457. Date of Electronic Publication: 2022 Feb 01.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Cincinnati, American Society of Pharmacognosy.
مواضيع طبية MeSH:	Alkaloids/chemistry , Alkaloids/pharmacology , Rubiaceae*/chemistry, Cell Proliferation ; Immunosuppressive Agents/pharmacology ; Molecular Structure
مستخلص:	Continued interest in bioactive alkaloids led to the isolation of two undescribed alkaloids, ophiorrhines F ( 1 ) and G ( 2 ), from the aerial parts of Ophiorrhiza japonica. Their structures were elucidated based on spectroscopic methods, electronic circular dichroism, and calculated NMR with DP4+ analysis. These two alkaloids represent key biological genetic intermediates in the formation of ring C in the ophiorrhines. Compound 1 exhibited good inhibition on LPS-induced B cell proliferation with an IC 50 value of 0.38 μM and showed significant selective inhibitory activity on a B cell proliferation response with a selective index of 548.42. A preliminary study indicated that 1 may have a new mechanism of immunosuppression.
المشرفين على المادة:	0 (Alkaloids) 0 (Immunosuppressive Agents)
تواريخ الأحداث:	Date Created: 20220201 Date Completed: 20220428 Latest Revision: 20220428
رمز التحديث:	20221213
DOI:	10.1021/acs.jnatprod.1c01085
PMID:	35104138
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1520-6025
DOI:	10.1021/acs.jnatprod.1c01085