دورية أكاديمية
Loss of TET2 Tips the Scales Toward Tumorigenesis.
| العنوان: | Loss of TET2 Tips the Scales Toward Tumorigenesis. |
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| المؤلفون: | Capell BC; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: capellb@pennmedicine.upenn.edu. |
| المصدر: | The Journal of investigative dermatology [J Invest Dermatol] 2022 May; Vol. 142 (5), pp. 1253-1255. Date of Electronic Publication: 2022 Jan 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Carcinoma, Squamous Cell*/genetics , Dioxygenases*/genetics, 5-Methylcytosine ; Cell Transformation, Neoplastic/genetics ; DNA Methylation ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism |
| مستخلص: | DNA methylation and demethylation function in the balance between cellular differentiation and cancer. Although the roles of DNA methyltransferases have been extensively explored in epidermal biology, ten-eleven translocation (TET) demethylase enzymes are poorly understood. In their new article in the Journal of Investigative Dermatology, Boudra et al. present evidence for a tumor-suppressive role of TET2 and its regulation of 5-hydroxymethylcytosine in the prevention of squamous cell carcinomas. (Copyright © 2021 The Author. Published by Elsevier Inc. All rights reserved.) |
| References: | J Invest Dermatol. 2020 Jun;140(6):1266-1275.e3. (PMID: 31837302) Cell Rep. 2019 Sep 3;28(10):2480-2490.e4. (PMID: 31484061) Cell Stem Cell. 2016 Oct 6;19(4):491-501. (PMID: 27476967) Nature. 2010 Jan 28;463(7280):563-7. (PMID: 20081831) Cell Rep. 2016 May 17;15(7):1566-1579. (PMID: 27160912) Elife. 2017 Apr 20;6:. (PMID: 28425913) Cell Rep. 2017 Aug 15;20(7):1744. (PMID: 28813683) PLoS One. 2019 Dec 20;14(12):e0223341. (PMID: 31860637) Nat Rev Mol Cell Biol. 2019 Oct;20(10):590-607. (PMID: 31399642) Nat Commun. 2018 Feb 8;9(1):577. (PMID: 29422656) J Invest Dermatol. 2022 May;142(5):1270-1279.e2. (PMID: 34695415) J Invest Dermatol. 2012 Dec;132(12):2681-90. (PMID: 22763785) |
| معلومات مُعتمدة: | P30 ES013508 United States ES NIEHS NIH HHS; R01 AR077615 United States AR NIAMS NIH HHS |
| المشرفين على المادة: | 0 (DNA-Binding Proteins) 0 (Proto-Oncogene Proteins) 6R795CQT4H (5-Methylcytosine) EC 1.13.11.- (Dioxygenases) EC 1.13.11.- (TET2 protein, human) |
| تواريخ الأحداث: | Date Created: 20220203 Date Completed: 20220426 Latest Revision: 20221224 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9128576 |
| DOI: | 10.1016/j.jid.2021.11.023 |
| PMID: | 35109986 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1523-1747 |
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| DOI: | 10.1016/j.jid.2021.11.023 |