دورية أكاديمية
أعرض في EDS

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia.

التفاصيل البيبلوغرافية
العنوان: Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia.
المؤلفون: Lillywhite A; Pain Centre Versus Arthritis, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham, United Kingdom., Woodhams SG; Pain Centre Versus Arthritis, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham, United Kingdom., Gonçalves SV; Pain Centre Versus Arthritis, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham, United Kingdom., Watson DJG; School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham, United Kingdom., Li L; Pain Centre Versus Arthritis, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham, United Kingdom., Burston JJ; Pain Centre Versus Arthritis, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham, United Kingdom., Gowler PRW; Pain Centre Versus Arthritis, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham, United Kingdom., Canals M; School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, Midlands, United Kingdom., Walsh DA; Pain Centre Versus Arthritis, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; School of Medicine, University of Nottingham, Nottingham, United Kingdom.; NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Hathway GJ; Pain Centre Versus Arthritis, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Chapman V; Pain Centre Versus Arthritis, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; School of Life Sciences, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.; NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom.
المصدر: Pain reports [Pain Rep] 2022 Feb 03; Vol. 6 (4), pp. e956. Date of Electronic Publication: 2022 Feb 03 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 101683899 Publication Model: eCollection Cited Medium: Internet ISSN: 2471-2531 (Electronic) Linking ISSN: 24712531 NLM ISO Abbreviation: Pain Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Baltimore, MD : Wolters Kluwer, [2016]-
مستخلص: Introduction: Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises.
Objectives: We tested the hypothesis that the interaction between anxiety, chronic pain, and opioid use results from altered endogenous opioid function.
Methods: A genetic model of negative affect, the Wistar-Kyoto (WKY) rat, was combined with intra-articular injection of monosodium iodoacetate (MIA; 1 mg) to mimic clinical presentation. Effects of systemic morphine (0.5-3.5 mg·kg -1 ) on pain behaviour and spinal nociceptive neuronal activity were compared in WKY and normo-anxiety Wistar rats 3 weeks after MIA injection. Endogenous opioid function was probed by the blockade of opioid receptors (0.1-1 mg·kg -1 systemic naloxone), quantification of plasma β-endorphin, and expression and phosphorylation of spinal mu-opioid receptor (MOR).
Results: Monosodium iodoacetate-treated WKY rats had enhanced OA-like pain, blunted morphine-induced analgesia, and greater mechanical hypersensitivity following systemic naloxone, compared with Wistar rats, and elevated plasma β-endorphin levels compared with saline-treated WKY controls. Increased MOR phosphorylation at the master site (serine residue 375) in the spinal cord dorsal horn of WKY rats with OA-like pain ( P = 0.0312) indicated greater MOR desensitization.
Conclusions: Reduced clinical analgesic efficacy of morphine was recapitulated in a model of high anxiety and OA-like pain, in which endogenous opioid tone was altered, and MOR function attenuated, in the absence of previous exogenous opioid ligand exposure. These findings shed new light on the mechanisms underlying the increased opioid analgesic use in high anxiety patients with chronic pain.
Competing Interests: The authors have no conflicts of interest to declare.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.
(Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.)
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معلومات مُعتمدة: MC_PC_19095 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: Animal models; Anxiety; Arthritis; Opioids; Pain
تواريخ الأحداث: Date Created: 20220207 Latest Revision: 20220501
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8568395
DOI: 10.1097/PR9.0000000000000956
PMID: 35128295
قاعدة البيانات: MEDLINE
الوصف
تدمد:2471-2531
DOI:10.1097/PR9.0000000000000956