دورية أكاديمية
Emergence of Neisseria meningitidis W South American sublineage strain variant in Brazil: disease and carriage.
| العنوان: | Emergence of Neisseria meningitidis W South American sublineage strain variant in Brazil: disease and carriage. |
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| المؤلفون: | Lemos APS; Centro de Bacteriologia, Instituto Adolfo Lutz, São Paulo, Brazil., Gorla MCO; Centro de Bacteriologia, Instituto Adolfo Lutz, São Paulo, Brazil., de Moraes C; Coordenação Geral de Emergências em Saúde Pública, Brasília, Distrito Federal, Brazil., Willemann MC; Universidade Federal de Santa Catarina, Santa Catarina, Brazil., Sacchi CT; Laboratório Estratégico, Instituto Adolfo Lutz, São Paulo, Brazil., Fukasawa LO; Centro de Imunologia, Instituto Adolfo Lutz, São Paulo, Brazil., Camargo CH; Centro de Bacteriologia, Instituto Adolfo Lutz, São Paulo, Brazil., Barreto G; Vigilância Epidemiológica de Santa Catarina, Santa Catarina, Brazil., Rodrigues DS; Laboratório de Saúde Pública de Santa Catarina, Santa Catarina, Brazil., Gonçalves MG; Centro de Imunologia, Instituto Adolfo Lutz, São Paulo, Brazil., Higa FT; Centro de Imunologia, Instituto Adolfo Lutz, São Paulo, Brazil., Salgado MM; Centro de Imunologia, Instituto Adolfo Lutz, São Paulo, Brazil., de Moraes JC; Faculdade de Medicina da Santa Casa de São Paulo, São Paulo, Brazil. |
| المصدر: | Journal of medical microbiology [J Med Microbiol] 2022 Feb; Vol. 71 (2). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Microbiology Society Country of Publication: England NLM ID: 0224131 Publication Model: Print Cited Medium: Internet ISSN: 1473-5644 (Electronic) Linking ISSN: 00222615 NLM ISO Abbreviation: J Med Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : London : Microbiology Society Original Publication: 1968-1995: Edinburgh, Livingstone. |
| مواضيع طبية MeSH: | Meningococcal Infections*/epidemiology , Neisseria meningitidis*/genetics, Adolescent ; Brazil/epidemiology ; Cross-Sectional Studies ; Humans ; Serogroup |
| مستخلص: | Introduction. Invasive meningococcal disease is a major health problem, impacting morbidity and mortality worldwide. Exploratory genomics has revealed insights into adaptation, transmissibility and virulence to elucidate endemic, outbreaks or epidemics caused by Neisseria meningitidis serogroup W (MenW) strains. Gap Statement. Limited information on the genomics of Neisseria meningitis serogroup W ST11/cc11 is available from emerging countries, especially in contemporary isolates. Aim. To (i) describe the antigenic diversity and distribution of genetic lineages of N. meningitidis serogroup W circulating in Brazil; (ii) study the carriage prevalence of hypervirulent clones in adolescents students and (iii) analyse the potential risk factors for meningococcal carriage. Methodology. Using whole-genome sequencing, we analysed the genomic diversity of 92 invasive N. meningitidis serogroup W isolates circulating in Brazil from 2016 to 2019. A cross-sectional survey of meningococcal carriage was conducted in 2019, in the city of Florianópolis, Brazil, among a representative sample of 538 students. Results. A predominance (58.5 %, 41/82) of ST11/cc11 presenting PorB2-144, PorA VR1-5, VR2-2, FetA 1-1, and a novel fHbp peptide 1241 was found on invasive N. meningitidis W isolates, on the other hand, a high diversity of clonal complexes was found among carriage isolates. The overall carriage rate was 7.5 % (40/538). A total of 28 of 538 swab samples collected were culture positive for N. meningitidis , including four serogroup/genogroup B isolates (14.8 %;4/27), 1 serogroup/genogroup Y isolate (3.7 %;1/27), 22 (81.5 %; 22/27) non-groupable isolates. No MenW isolate was identified among carriages isolates. Conclusion. This report describes the emergence of the new MenW ST11/cc11 South America sublineage variant, named here, 2016 strain, carrying a novel fHbp peptide 1241, but its emergence, was not associated with an increased MenW carriage prevalence. Continuous surveillance is necessary to ascertain the role of this sublineage diversification and how its emergence can impact transmission. |
| فهرسة مساهمة: | Keywords: Neisseria meningitidis; ST11; carriage; cc11; serogroup W; whole-genome sequencing |
| تواريخ الأحداث: | Date Created: 20220211 Date Completed: 20220228 Latest Revision: 20220228 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1099/jmm.0.001484 |
| PMID: | 35144719 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1473-5644 |
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| DOI: | 10.1099/jmm.0.001484 |