دورية أكاديمية
أعرض في EDS

Prevalence and Factors Associated with Optic Disc Tilt in the Primary Open-Angle African American Glaucoma Genetics Study.

التفاصيل البيبلوغرافية
العنوان: Prevalence and Factors Associated with Optic Disc Tilt in the Primary Open-Angle African American Glaucoma Genetics Study.
المؤلفون: Daniel E; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: ebdaniel@pennmedicine.upenn.edu., Addis V; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania., Maguire MG; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania., McGeehan B; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania., Chen M; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania., Salowe RJ; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania., Zenebe-Gete S; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania., Meer E; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Lee R; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania., Smith E; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania., Gudiseva HV; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania., Sankar PS; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania., O'Brien JM; Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania.
المصدر: Ophthalmology. Glaucoma [Ophthalmol Glaucoma] 2022 Sep-Oct; Vol. 5 (5), pp. 544-553. Date of Electronic Publication: 2022 Feb 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101730510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-4196 (Electronic) Linking ISSN: 25894196 NLM ISO Abbreviation: Ophthalmol Glaucoma Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Elsevier Inc., [2018]-
مواضيع طبية MeSH: Glaucoma*/complications , Myopia*/complications , Optic Disk*, Black or African American/genetics ; Cross-Sectional Studies ; Female ; Humans ; Male ; Prevalence
مستخلص: Purpose: To investigate the prevalence and factors associated with optic disc tilt in the eyes of Black Americans with glaucoma.
Design: Cross-sectional.
Participants: Subjects with glaucoma participating in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study.
Methods: Stereo pairs of optic disc images were assessed independently by POAAGG-certified nonphysician graders for quantitative features including maximum and minimum linear disc diameters, and qualitative features including gradeability of images, shape of the cup, rim plane position, β-peripapillary atrophy, sloping region adjacent to the outer disc margin, and rim pallor. Discrepancies were adjudicated by an ophthalmologist. Descriptive statistics and P values were generated for associations of tilt with demographic and ocular characteristics. Stepwise multivariable analysis was performed with logistic regression using Generalized Estimating Equations (GEEs) to account for inter-eye correlation within subjects.
Main Outcome Measures: Tilt Ovality Index (TOI) of >1.30 and Stereoscopically Identified optic disc Tilt (SIT).
Results: Among 1251 subjects with data on both eyes, 104 (8.3%) had TOI. Subjects with TOI were less likely to be male (adjusted odds ratio [aOR], 0.46, 95% confidence interval [CI], 0.29-0.74, P < 0.001). Eyes with TOI were less likely to have large cup disc ratios (aOR, 0.18, 95% CI, 0.06-0.53, P < 0.001) and less likely to have cylinder-shaped cups compared with conical-shaped cups (aOR, 0.31, 95% CI, 0.19-0.49, P < 0.001). Among 1007 subjects with data on both eyes, 254 (25.2%) had SIT. Subjects with SIT were younger (aOR, 0.95, 95% CI, 0.93-0.96, P < 0.001), and eyes with SIT were more likely to have oval-shaped discs compared with round discs (aOR, 1.82, 95% CI, 1.32-2.52, P < 0.001), more likely to have a sloping region adjacent to the outer disc margin instead of being flat (aOR, 3.26, 95% CI, 2.32-4.59, P < 0.001), and less likely to have cylinder-shaped cups compared with conical-shaped cups (aOR, 0.59, 95% CI, 0.41-0.85, P < 0.001). Both TOI and SIT were not associated with myopia.
Conclusions: There are substantial numbers of tilted optic discs in glaucoma patients with African ancestry. They occur more frequently in female subjects and younger subjects and are associated with several ocular features but not with myopia.
(Copyright © 2022 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: P30 EY001583 United States EY NEI NIH HHS; R01 EY023557 United States EY NEI NIH HHS
فهرسة مساهمة: Keywords: Black Americans; Open-angle glaucoma; Ovality Index; Stereoscopically Identified optic disc Tilt; Tilted optic discs
تواريخ الأحداث: Date Created: 20220213 Date Completed: 20220928 Latest Revision: 20230902
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9363533
DOI: 10.1016/j.ogla.2022.02.004
PMID: 35151898
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-4196
DOI:10.1016/j.ogla.2022.02.004