دورية أكاديمية
أعرض في EDS

Intra-articular Versus Intravenous Tranexamic Acid in Primary Total Knee Replacement.

التفاصيل البيبلوغرافية
العنوان: Intra-articular Versus Intravenous Tranexamic Acid in Primary Total Knee Replacement.
المؤلفون: Furqan A; Orthopaedics, Shifa International Hospital, Islamabad, PAK., Hafeez S; Orthopedic Surgery, Shifa International Hospital, Islamabad, PAK., Khan F; Orthopaedics and Traumatology, Shifa International Hospital, Islamabad, PAK., Orakzai SH; Orthopedics and Traumatology, Shifa International Hospital, Islamabad, PAK., Nur AN; Orthopedics and Traumatology, Shifa International Hospital, Islamabad, PAK., Khan MA; Orthopaedics and Trauma, Shifa International Hospital, Islamabad, PAK.
المصدر: Cureus [Cureus] 2022 Jan 09; Vol. 14 (1), pp. e21052. Date of Electronic Publication: 2022 Jan 09 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Background Total knee replacement (TKR) is an artificial joint surgical procedure that replaces the damaged articular surfaces of the knee joint. Despite several studies on the efficacy of intra-articular and intravenous Tranexamic acid (TX) use in reducing blood loss following TKR, the route of TXA administration is still an ongoing topic of debate. Our study aimed to compare total knee replacement efficacy (hemoglobin level, hematocrit level, hospital stay, and complications) of intra-articular and intravenous tranexamic acid administration. Material and Methods  A Prospective study was conducted at the Department of Orthopedics, Shifa International Hospital, Islamabad. The study duration was six months (August 2020 to February 2021). A sample size of 60 patients was calculated using the WHO calculator. Patients were selected through non-probability consecutive sampling. Patients were randomly divided into two groups; Group A was given intraarticular TXA, while group B was given intra-venous TXA following total knee replacement. Patients were followed for 48 hours. Data were analyzed using SPSS version 24. An Independent T-test was applied, and a P value≤0.05 was considered significant. Results A total of 60 patients were included in the study. There were 20 (33.3%) male and female 40 (66.7%). The mean age of patients was 64.4±10.8SD. Post-operative hemoglobin level in group A was 11.09±0.39SD, and in group B was 9.93±1.73SD (p=0.03). Postoperatively, the mean HCT level in group A was 30.53±4.26SD and group B 26.88±5.48SD (p=0.01). Conclusion Intra-articular administration of TXA is more effective than intravenous administration in controlling postoperative blood loss following total knee replacement.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2022, Furqan et al.)
References: Knee. 2002 Dec;9(4):261-6. (PMID: 12424032)
J Arthroplasty. 2014 Aug;29(8):1521-4. (PMID: 24726174)
J Bone Joint Surg Am. 2012 Jul 3;94(13):1153-9. (PMID: 22623147)
Anaesth Intensive Care. 2003 Oct;31(5):529-37. (PMID: 14601276)
Knee Surg Sports Traumatol Arthrosc. 2013 Aug;21(8):1869-74. (PMID: 22729012)
Clin Orthop Relat Res. 1989 Nov;(248):13-4. (PMID: 2805470)
J Arthroplasty. 2015 Mar;30(3):384-6. (PMID: 25458092)
Knee. 2001 Oct;8(3):187-94. (PMID: 11706726)
J Arthroplasty. 2014 Dec;29(12):2342-6. (PMID: 25007725)
J Bone Joint Surg Am. 2001 Dec;83(12):1856-64. (PMID: 11741066)
Transfusion. 2005 Aug;45(8):1302-7. (PMID: 16078916)
Drugs. 2012 Mar 26;72(5):585-617. (PMID: 22397329)
J Arthroplasty. 2013 Aug;28(7):1080-3. (PMID: 23541868)
Knee. 2005 Apr;12(2):121-7. (PMID: 15749447)
J Bone Joint Surg Am. 2014 Dec 3;96(23):1937-44. (PMID: 25471907)
Thromb Res. 2009 Mar;123(5):687-96. (PMID: 19007970)
Knee. 2014 Dec;21(6):987-93. (PMID: 25450009)
J Bone Joint Surg Br. 2011 Dec;93(12):1577-85. (PMID: 22161917)
J Arthroplasty. 2015 Mar;30(3):365-8. (PMID: 25458093)
J Arthroplasty. 2014 Aug;29(8):1528-31. (PMID: 24768543)
فهرسة مساهمة: Keywords: blood loss; intra-articular; intra-venous; postoperative blood loss; total knee replacement; tranexamic acid
تواريخ الأحداث: Date Created: 20220214 Latest Revision: 20220216
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8824405
DOI: 10.7759/cureus.21052
PMID: 35155018
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.21052