دورية أكاديمية
Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics.
العنوان: | Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics. |
---|---|
المؤلفون: | Gao Y; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Kabotyanski EB; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Shepherd JH; The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Villegas E; University of Houston-Downtown, Houston, TX 77002, USA., Acosta D; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Hamor C; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Sun T; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Verna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Montmeyor-Garcia C; Canadian Blood Services, Toronto, ON M5G 2M1, Canada., He X; The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dobrolecki LE; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Westbrook TF; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Verna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Lewis MT; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Hilsenbeck SG; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Zhang XH; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; McNair Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Perou CM; The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Rosen JM; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. |
المصدر: | Cancer research communications [Cancer Res Commun] 2021 Dec; Vol. 1 (3), pp. 178-193. Date of Electronic Publication: 2021 Dec 27. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun |
أسماء مطبوعة: | Original Publication: [Philadelphia, Pennsylvania] : American Association for Cancer Research, [2021]- |
مواضيع طبية MeSH: | Triple Negative Breast Neoplasms*/drug therapy, Humans ; Mice ; Animals ; Genes, Tumor Suppressor ; Biomarkers ; Protein Serine-Threonine Kinases/genetics |
مستخلص: | Polo-like kinase (PLK) family members play important roles in cell cycle regulation. The founding member PLK1 is oncogenic and preclinically validated as a cancer therapeutic target. Paradoxically, frequent loss of chromosome 5q11-35 which includes PLK2 is observed in basal-like breast cancer. In this study, we found that PLK2 was tumor suppressive in breast cancer, preferentially in basal-like and triple-negative breast cancer (TNBC) subtypes. Knockdown of PLK1 rescued phenotypes induced by PLK2-loss both in vitro and in vivo . We also demonstrated that PLK2 directly interacted with PLK1 at prometaphase through the kinase but not the polo-box domains of PLK2, suggesting PLK2 functioned at least partially through the interaction with PLK1. Furthermore, an improved treatment response was seen in both Plk2-deleted/low mouse preclinical and PDX TNBC models using the PLK1 inhibitor volasertib alone or in combination with carboplatin. Re-expression of PLK2 in an inducible PLK2-null mouse model reduced the therapeutic efficacy of volasertib. In summary, this study delineates the effects of chromosome 5q loss in TNBC that includes PLK2, the relationship between PLK2 and PLK1, and how this may render PLK2-deleted/low tumors more sensitive to PLK1 inhibition in combination with chemotherapy. Competing Interests: Conflict of Interest: CMP is an equity stockholder and board member of BioClassifier and GeneCentric Therapeutics. CMP is also listed as an inventor on patent applications for the Breast PAM50. MTL is a Founder and Limited Partner of StemMed Ltd, and a Manager of StemMed Holdings, LLC, its General Partner. MTL is also a Founder of, and equity holder in, Tvardi Therapeutics Inc. The other authors declare that they have no competing interests. |
References: | Mod Pathol. 2010 May;23 Suppl 2:S60-4. (PMID: 20436504) BMC Cancer. 2014 Sep 18;14:678. (PMID: 25239093) Nature. 2012 Aug 16;488(7411):337-42. (PMID: 22895339) Oncogene. 2015 Dec 3;34(49):5997-6006. (PMID: 25746005) Transl Oncol. 2017 Feb;10(1):22-32. (PMID: 27888710) Genome Biol. 2013 Nov 12;14(11):R125. (PMID: 24220145) Cell Cycle. 2008 Nov 15;7(22):3548-55. (PMID: 19001868) Clin Cancer Res. 2019 Jul 1;25(13):4049-4062. (PMID: 30890549) Nat Rev Cancer. 2006 Apr;6(4):321-30. (PMID: 16557283) J Cell Biol. 2015 Mar 16;208(6):661-9. (PMID: 25753036) N Engl J Med. 2004 Dec 30;351(27):2817-26. (PMID: 15591335) Blood. 2006 Jan 1;107(1):250-6. (PMID: 16160013) Cancer Discov. 2021 May;11(5):1016-1023. (PMID: 33648929) Neoplasia. 2018 Mar;20(3):244-255. (PMID: 29448085) Mol Cell Biol. 1992 Sep;12(9):4164-9. (PMID: 1508211) Clin Cancer Res. 2010 Jan 15;16(2):384-9. (PMID: 20068088) J Biol Chem. 2009 Nov 13;284(46):32053-65. (PMID: 19700763) Development. 2014 Apr;141(7):1562-71. (PMID: 24598160) Cancer Res. 2013 Jan 15;73(2):813-23. (PMID: 23144294) Biostatistics. 2007 Jan;8(1):118-27. (PMID: 16632515) Lancet. 2004 Sep 4-10;364(9437):858-68. (PMID: 15351193) Oncogene. 2005 Jan 10;24(2):292-8. (PMID: 15640845) Mol Cancer Res. 2003 Mar;1(5):376-84. (PMID: 12651910) Cancer Cell. 2018 Apr 9;33(4):676-689.e3. (PMID: 29622463) J Med Chem. 2011 Sep 22;54(18):6254-76. (PMID: 21812421) Biochim Biophys Acta. 2012 Dec;1824(12):1366-73. (PMID: 22828320) Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16910-5. (PMID: 20837533) Cell. 2019 Nov 14;179(5):1191-1206.e21. (PMID: 31730857) Dis Model Mech. 2016 Jul 1;9(7):749-57. (PMID: 27149990) Mol Cancer Ther. 2009 Mar;8(3):672-81. (PMID: 19276159) Mol Cell Biol. 2003 Oct;23(19):6936-43. (PMID: 12972611) Curr Biol. 2004 Jul 13;14(13):1200-7. (PMID: 15242618) Cell Cycle. 2011 Jul 15;10(14):2255-62. (PMID: 21654194) Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14542-6. (PMID: 19706541) BMC Syst Biol. 2017 Oct 3;11(Suppl 5):87. (PMID: 28984210) Oncotarget. 2016 Apr 12;7(15):19666-79. (PMID: 26910911) Mol Cell Biol. 2008 Nov;28(22):6870-6. (PMID: 18794363) Cell. 2005 Jun 17;121(6):837-48. (PMID: 15960972) Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1736-40. (PMID: 8127874) Oncogene. 2005 Jan 10;24(2):287-91. (PMID: 15640844) Invest New Drugs. 2015 Jun;33(3):611-20. (PMID: 25794535) Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7. (PMID: 28807782) Nature. 2012 Oct 4;490(7418):61-70. (PMID: 23000897) Oncogene. 2003 Sep 29;22(42):6570-8. (PMID: 14528282) Nat Rev Mol Cell Biol. 2004 Jun;5(6):429-40. (PMID: 15173822) Oncotarget. 2012 Jan;3(1):78-83. (PMID: 22289679) Oncogene. 2005 Jan 10;24(2):267-76. (PMID: 15640842) Ann Hematol. 2011 Sep;90(9):1037-45. (PMID: 21340720) Oncogene. 2000 Feb 21;19(8):1052-8. (PMID: 10713689) CA Cancer J Clin. 2021 Jan;71(1):7-33. (PMID: 33433946) Cancer Biol Ther. 2013 May;14(5):379-89. (PMID: 23380594) Cancer Lett. 2016 Oct 1;380(2):457-466. (PMID: 27423313) Mol Ther. 2008 Apr;16(4):698-706. (PMID: 18362927) Drug Resist Updat. 2005 Jun;8(3):131-46. (PMID: 15894512) Nature. 2010 Feb 18;463(7283):899-905. (PMID: 20164920) Lab Invest. 2019 Sep;99(9):1275-1286. (PMID: 30996295) Mol Cell Proteomics. 2011 Feb;10(2):M110.001628. (PMID: 21044950) Breast Cancer Res Treat. 2019 Feb;174(1):1-13. (PMID: 30488345) J Clin Oncol. 2002 Feb 1;20(3):719-26. (PMID: 11821453) Breast Cancer Res. 2019 May 22;21(1):67. (PMID: 31118047) Cell Mol Life Sci. 2010 Jun;67(12):1957-70. (PMID: 20148280) Nat Cell Biol. 2019 Sep;21(9):1113-1126. (PMID: 31451770) Cell Cycle. 2007 Oct 15;6(20):2571-8. (PMID: 17912033) Leukemia. 2015 Jan;29(1):11-9. (PMID: 25027517) Mol Cancer Ther. 2016 Jul;15(7):1427-35. (PMID: 27330107) PLoS One. 2019 Nov 21;14(11):e0224420. (PMID: 31751384) Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886) DNA Seq. 2001;11(6):527-33. (PMID: 11696980) Cell. 2011 Mar 4;144(5):703-18. (PMID: 21376233) Nature. 2020 Dec;588(7837):331-336. (PMID: 33299191) N Engl J Med. 1989 Feb 23;320(8):479-84. (PMID: 2644532) JAMA Oncol. 2021 Apr 01;7(4):603-608. (PMID: 33599688) Clin Cancer Res. 2009 May 1;15(9):3094-102. (PMID: 19383823) Breast Cancer Res Treat. 2012 Jun;133(3):865-80. (PMID: 22048815) Exp Hematol Oncol. 2012 Dec 10;1(1):38. (PMID: 23227884) Neoplasma. 1991;38(2):147-55. (PMID: 2041574) Onco Targets Ther. 2015 Nov 20;8:3475-88. (PMID: 26640387) Nat Rev Mol Cell Biol. 2009 Apr;10(4):265-75. (PMID: 19305416) Hepatology. 2010 Mar;51(3):857-68. (PMID: 20112253) |
معلومات مُعتمدة: | R01 CA148761 United States CA NCI NIH HHS; P50 CA058223 United States CA NCI NIH HHS; P30 CA125123 United States CA NCI NIH HHS; P30 DK056338 United States DK NIDDK NIH HHS; S10 RR024574 United States RR NCRR NIH HHS; T32 CA203690 United States CA NCI NIH HHS; P50 CA186784 United States CA NCI NIH HHS |
المشرفين على المادة: | 0 (Biomarkers) EC 2.7.11.- (PLK2 protein, human) EC 2.7.11.1 (Protein Serine-Threonine Kinases) |
تواريخ الأحداث: | Date Created: 20220214 Date Completed: 20230727 Latest Revision: 20230727 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC8827906 |
DOI: | 10.1158/2767-9764.crc-21-0106 |
PMID: | 35156101 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!