دورية أكاديمية
أعرض في EDS

Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies.

التفاصيل البيبلوغرافية
العنوان: Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies.
المؤلفون: Zamzami MA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Centre of Artificial Intelligence in Precision Medicines, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
المصدر: Cells [Cells] 2022 Jan 24; Vol. 11 (3). Date of Electronic Publication: 2022 Jan 24.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Inosine Triphosphate*/metabolism , Neoplasms*/drug therapy , Neoplasms*/genetics , Pyrophosphatases*/genetics , Pyrophosphatases*/metabolism, Humans ; Inosine ; Mutation ; Nucleosides ; Nucleotides/metabolism ; Inosine Triphosphatase
مستخلص: Inosine triphosphate pyrophosphatase (ITPase) is an enzyme encoded by the ITPA gene and functions to prevent the incorporation of noncanonical purine nucleotides into DNA and RNA. Specifically, the ITPase catalyzed the hydrolysis of (deoxy) nucleoside triphosphates ((d) NTPs) into the corresponding nucleoside monophosphate with the concomitant release of pyrophosphate. Recently, thiopurine drug metabolites such as azathioprine have been included in the lists of ITPase substrates. Interestingly, inosine or xanthosine triphosphate (ITP/XTP) and their deoxy analogs, deoxy inosine or xanthosine triphosphate (dITP/dXTP), are products of important biological reactions such as deamination that take place within the cellular compartments. However, the incorporation of ITP/XTP, dITP/dXTP, or the genetic deficiency or polymorphism of the ITPA gene have been implicated in many human diseases, including infantile epileptic encephalopathy, early onset of tuberculosis, and the responsiveness of patients to cancer therapy. This review provides an up-to-date report on the ITPase enzyme, including information regarding its discovery, analysis, and cellular localization, its implication in human diseases including cancer, and its therapeutic potential, amongst others.
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فهرسة مساهمة: Keywords: cancer therapy; deamination; inosine triphosphate pyrophosphatase (ITPase); polymorphism; purine metabolism
المشرفين على المادة: 0 (Nucleosides)
0 (Nucleotides)
132-06-9 (Inosine Triphosphate)
5A614L51CT (Inosine)
EC 3.6.1.- (Pyrophosphatases)
EC 3.6.1.9 (ITPA protein, human)
تواريخ الأحداث: Date Created: 20220215 Date Completed: 20220408 Latest Revision: 20231213
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8833965
DOI: 10.3390/cells11030384
PMID: 35159194
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells11030384