دورية أكاديمية
Gut microbiota modulation by jabuticaba peel and its effect on glucose metabolism via inflammatory signaling.
العنوان: | Gut microbiota modulation by jabuticaba peel and its effect on glucose metabolism via inflammatory signaling. |
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المؤلفون: | Loubet Filho PS; Laboratory of Nutrition and Metabolism, School of Food Engineering, University of Campinas - UNICAMP, P.O. Box 6121, 13083-862, Campinas, SP, Brazil., Baseggio AM; Laboratory of Nutrition and Metabolism, School of Food Engineering, University of Campinas - UNICAMP, P.O. Box 6121, 13083-862, Campinas, SP, Brazil., Vuolo MM; Laboratory of Nutrition and Metabolism, School of Food Engineering, University of Campinas - UNICAMP, P.O. Box 6121, 13083-862, Campinas, SP, Brazil., Reguengo LM; Laboratory of Nutrition and Metabolism, School of Food Engineering, University of Campinas - UNICAMP, P.O. Box 6121, 13083-862, Campinas, SP, Brazil., Telles Biasoto AC; Brazilian Agricultural Research Corporation, Embrapa Tropical Semi-arid, 56302-970, Petrolina, PE, Brazil., Correa LC; Brazilian Agricultural Research Corporation, Embrapa Tropical Semi-arid, 56302-970, Petrolina, PE, Brazil., Junior SB; São Carlos Institute of Chemistry (IQSC), University of São Paulo (USP), São Carlos, SP, Brazil., Alves Cagnon VH; Department of Structural and Functional Biology, Institute of Biology, University of Campinas- UNICAMP, Bertrand Russel Av, Campinas, SP, Brazil., Betim Cazarin CB; Laboratory of Nutrition and Metabolism, School of Food Engineering, University of Campinas - UNICAMP, P.O. Box 6121, 13083-862, Campinas, SP, Brazil., Maróstica Júnior MR; Laboratory of Nutrition and Metabolism, School of Food Engineering, University of Campinas - UNICAMP, P.O. Box 6121, 13083-862, Campinas, SP, Brazil. |
المصدر: | Current research in food science [Curr Res Food Sci] 2022 Feb 10; Vol. 5, pp. 382-391. Date of Electronic Publication: 2022 Feb 10 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101771059 Publication Model: eCollection Cited Medium: Internet ISSN: 2665-9271 (Electronic) Linking ISSN: 26659271 NLM ISO Abbreviation: Curr Res Food Sci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Netherlands] : Elsevier B.V., [2019]- |
مستخلص: | Jabuticaba is a Brazilian berry known for its therapeutic potential against cancer, obesity, insulin resistance (IR), and others. It is a natural source of bioactive compounds, leading to better glucose metabolism, and attenuating obesity and IR through the reduction of pro-inflammatory status. The present study aimed to observe the prebiotic effect of freeze-dried jabuticaba peel (J) consumption on gut bacteria profile and describe its effects on IR derived from the lipopolysaccharides/Toll-like receptor-4 inflammatory pathway. Jabuticaba peel was chemically characterized, and its bioactive compounds were quantified. Twenty-four C57BL/6 mice were feed with a control diet (n = 6), control diet + J (n = 6), high-fat diet (HF) (n = 6), and HF + J (n = 6) for thirteen weeks. Gut bacteriota (16s RNA sequencing), glucose metabolism (fasting glucose and insulin, OGTT, ITT, HOMA-IR, and β, QUICKI), and inflammatory status (serum lipopolysaccharide, and protein expression) were assessed. The main bioactive compounds found in J were dietary fiber, and anthocyanins, and its consumption along with a healthy diet reduced the abundance of Firmicutes and Actinobacteriota phyla (p < 0.01), increased the Muribaculaceae and Lachnospiraceae families, and Faecalicatena genus (p < 0.05). The correlation test indicates a negative correlation between the Muribaculaceae and glucose metabolism. Jabuticaba peel is a nutritive source of bioactive compounds with prebiotic effects. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.) |
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فهرسة مساهمة: | Keywords: Berries; Bioactive compounds; Dysbiosis; Insulin resistance; Obesity; Prebiotics |
تواريخ الأحداث: | Date Created: 20220224 Latest Revision: 20220225 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC8850559 |
DOI: | 10.1016/j.crfs.2022.02.001 |
PMID: | 35198998 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2665-9271 |
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DOI: | 10.1016/j.crfs.2022.02.001 |