دورية أكاديمية
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In vivo MRI evaluation of anterograde manganese transport along the visual pathway following whole eye transplantation.

التفاصيل البيبلوغرافية
العنوان: In vivo MRI evaluation of anterograde manganese transport along the visual pathway following whole eye transplantation.
المؤلفون: Komatsu C; Department of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States., van der Merwe Y; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., He L; Department of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Department of Plastic, Aesthetic & Maxillofacial Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China., Kasi A; Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States., Sims JR; Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States., Miller MR; Department of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Rosner IA; Department of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States., Khatter NJ; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado, Denver, CO, United States; William Beaumont School of Medicine, Oakland University, Rochester, MI, United States., Su AA; Department of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado, Denver, CO, United States., Schuman JS; Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States; Neuroscience Institute, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States; Center for Neural Science, College of Arts and Science, New York University, New York, NY, United States; Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY, United States., Washington KM; Department of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado, Denver, CO, United States; Veterans Administration Pittsburgh Healthcare System, Pittsburgh, PA, United States., Chan KC; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States; Neuroscience Institute, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States; Center for Neural Science, College of Arts and Science, New York University, New York, NY, United States; Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY, United States; Department of Radiology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States. Electronic address: chuenwing.chan@fulbrightmail.org.
المصدر: Journal of neuroscience methods [J Neurosci Methods] 2022 Apr 15; Vol. 372, pp. 109534. Date of Electronic Publication: 2022 Feb 22.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7905558 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-678X (Electronic) Linking ISSN: 01650270 NLM ISO Abbreviation: J Neurosci Methods Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Manganese*/metabolism , Visual Pathways*/diagnostic imaging, Animals ; Contrast Media/metabolism ; Magnetic Resonance Imaging/methods ; Mammals ; Optic Nerve/diagnostic imaging ; Rats
مستخلص: Background: Since adult mammalian retinal ganglion cells cannot regenerate after injury, we have recently established a whole-eye transplantation (WET) rat model that provides an intact optical system to investigate potential surgical restoration of irreversible vision loss. However, it remains to be elucidated whether physiological axoplasmic transport exists in the transplanted visual pathway.
New Method: We developed an in vivo imaging model system to assess WET integration using manganese-enhanced magnetic resonance imaging (MEMRI) in rats. Since Mn 2+ is a calcium analogue and an active T1-positive contrast agent, the levels of anterograde manganese transport can be evaluated in the visual pathways upon intravitreal Mn 2+ administration into both native and transplanted eyes.
Results: No significant intraocular pressure difference was found between native and transplanted eyes, whereas comparable manganese enhancement was observed between native and transplanted intraorbital optic nerves, suggesting the presence of anterograde manganese transport after WET. No enhancement was detected across the coaptation site in the higher visual areas of the recipient brain.
Comparison With Existing Methods: Existing imaging methods to assess WET focus on either the eye or local optic nerve segments without direct visualization and longitudinal quantification of physiological transport along the transplanted visual pathway, hence the development of in vivo MEMRI.
Conclusion: Our established imaging platform indicated that essential physiological transport exists in the transplanted optic nerve after WET. As neuroregenerative approaches are being developed to connect the transplanted eye to the recipient's brain, in vivo MEMRI is well-suited to guide strategies for successful WET integration for vision restoration.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: P30 EY008098 United States EY NEI NIH HHS; R01 EY013178 United States EY NEI NIH HHS; R01 EY028125 United States EY NEI NIH HHS
فهرسة مساهمة: Keywords: Anterograde transport; Magnetic resonance imaging; Manganese; Neuroregeneration; Optic nerve; Whole-eye transplantation
المشرفين على المادة: 0 (Contrast Media)
42Z2K6ZL8P (Manganese)
تواريخ الأحداث: Date Created: 20220224 Date Completed: 20220407 Latest Revision: 20230610
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8940646
DOI: 10.1016/j.jneumeth.2022.109534
PMID: 35202613
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-678X
DOI:10.1016/j.jneumeth.2022.109534