دورية أكاديمية
Synergistic Cytokine Production by ATP and PGE 2 via P2X4 and EP 3 Receptors in Mouse Bone-Marrow-Derived Mast Cells.
العنوان: | Synergistic Cytokine Production by ATP and PGE |
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المؤلفون: | Obayashi K; Laboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Gunma, Japan., Yoshida K; Laboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Gunma, Japan., Ito MA; Laboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Gunma, Japan., Mori T; Laboratory of Allergy and Immunology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Gunma, Japan., Yamamoto K; Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan., Imai T; Discovery Research Laboratories, Nippon Chemiphar Co., Ltd., Misato 341-0005, Saitama, Japan., Matsuoka I; Laboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370-0033, Gunma, Japan. |
المصدر: | Cells [Cells] 2022 Feb 10; Vol. 11 (4). Date of Electronic Publication: 2022 Feb 10. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مواضيع طبية MeSH: | Cell Degranulation* , Cytokines*/metabolism , Mast Cells*/metabolism , Receptors, Prostaglandin E, EP3 Subtype*/metabolism , Receptors, Purinergic P2X4*/metabolism, Adenosine Triphosphate/metabolism ; Animals ; Bone Marrow/metabolism ; Dinoprostone/metabolism ; Gene Expression ; Interleukin-6/metabolism ; Mice ; RNA, Messenger/metabolism |
مستخلص: | ATP is an important intercellular messenger in the extracellular space. In mast cells (MCs), ATP stimulates the ionotropic P2X4 receptor (P2X4R), resulting in enhanced degranulation and exacerbation of acute allergic reactions. In this study, we investigate whether ATP regulates inflammatory cytokine production in MCs. Gene expression was analyzed by quantitative RT-PCR, and cytokine production was measured using ELISA. The stimulation of mouse bone-marrow-derived MCs (BMMCs) with ATP alone had little effect on cytokine secretion. However, the co-stimulation with prostaglandin (PG) E |
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معلومات مُعتمدة: | Grant-in-Aid for Scientific Research Japan Society for the Promotion of Science |
فهرسة مساهمة: | Keywords: ATP; EP3 receptor; P2X4 receptor; bone-marrow-derived mast cells; prostaglandin E2 |
المشرفين على المادة: | 0 (Cytokines) 0 (Interleukin-6) 0 (Ptger3 protein, mouse) 0 (RNA, Messenger) 0 (Receptors, Prostaglandin E, EP3 Subtype) 0 (Receptors, Purinergic P2X4) 8L70Q75FXE (Adenosine Triphosphate) K7Q1JQR04M (Dinoprostone) |
تواريخ الأحداث: | Date Created: 20220225 Date Completed: 20220408 Latest Revision: 20220531 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC8870111 |
DOI: | 10.3390/cells11040616 |
PMID: | 35203267 |
قاعدة البيانات: | MEDLINE |
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