دورية أكاديمية
N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
| العنوان: | N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice. |
|---|---|
| المؤلفون: | Decoeur F; INRAE, Bordeaux INP, NutriNeuro, Université de Bordeaux, Bordeaux, France., Picard K; Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, Canada.; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.; Département de Médecine Moléculaire, Université Laval, Québec, QC, Canada., St-Pierre MK; Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, Canada.; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.; Département de Médecine Moléculaire, Université Laval, Québec, QC, Canada., Greenhalgh AD; INRAE, Bordeaux INP, NutriNeuro, Université de Bordeaux, Bordeaux, France., Delpech JC; INRAE, Bordeaux INP, NutriNeuro, Université de Bordeaux, Bordeaux, France., Sere A; INRAE, Bordeaux INP, NutriNeuro, Université de Bordeaux, Bordeaux, France., Layé S; INRAE, Bordeaux INP, NutriNeuro, Université de Bordeaux, Bordeaux, France., Tremblay ME; Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, Canada.; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.; Département de Médecine Moléculaire, Université Laval, Québec, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada., Nadjar A; INRAE, Bordeaux INP, NutriNeuro, Université de Bordeaux, Bordeaux, France.; Neurocentre Magendie, U1215, INSERM-Université de Bordeaux, Bordeaux, France.; Institut Universitaire de France (IUF), Paris, France. |
| المصدر: | Frontiers in cellular neuroscience [Front Cell Neurosci] 2022 Feb 10; Vol. 16, pp. 802411. Date of Electronic Publication: 2022 Feb 10 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5102 (Print) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007- |
| مستخلص: | Over the last century, westernization of dietary habits has led to a dramatic reduction in dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs). In particular, low maternal intake of n-3 PUFAs throughout gestation and lactation causes defects in brain myelination. Microglia are recognized for their critical contribution to neurodevelopmental processes, such as myelination. These cells invade the white matter in the first weeks of the post-natal period, where they participate in oligodendrocyte maturation and myelin production. Therefore, we investigated whether an alteration of white matter microglia accompanies the myelination deficits observed in the brain of n-3 PUFA-deficient animals. Macroscopic imaging analysis shows that maternal n-3 PUFA deficiency decreases the density of white matter microglia around post-natal day 10. Microscopic electron microscopy analyses also revealed alterations of microglial ultrastructure, a decrease in the number of contacts between microglia and myelin sheet, and a decreased amount of myelin debris in their cell body. White matter microglia further displayed increased mitochondrial abundance and network area under perinatal n-3 PUFA deficiency. Overall, our data suggest that maternal n-3 PUFA deficiency alters the structure and function of microglial cells located in the white matter of pups early in life, and this could be the key to understand myelination deficits during neurodevelopment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Decoeur, Picard, St-Pierre, Greenhalgh, Delpech, Sere, Layé, Tremblay and Nadjar.) |
| References: | Hum Brain Mapp. 2008 May;29(5):503-16. (PMID: 17133394) Methods Mol Biol. 2019;2034:97-110. (PMID: 31392680) J Neuropathol Exp Neurol. 2017 Sep 1;76(9):736-753. (PMID: 28859332) Cell Mol Life Sci. 2021 Apr;78(8):3907-3919. (PMID: 33507328) EMBO J. 2017 Nov 15;36(22):3292-3308. (PMID: 28963396) Brain Behav Immun Health. 2021 Jun 09;15:100281. (PMID: 34589781) Early Hum Dev. 2007 Dec;83(12):761-6. (PMID: 17920214) Br J Pharmacol. 2016 Feb;173(4):649-65. (PMID: 25800044) J Comp Neurol. 1978 Jul 1;180(1):139-63. (PMID: 649786) Prog Lipid Res. 1985;24(2):69-176. (PMID: 3916238) Glia. 2022 Jan;70(1):50-70. (PMID: 34519378) Neuron. 2019 Jan 16;101(2):207-223.e10. (PMID: 30606613) Int J Dev Neurosci. 2016 Feb;48:58-70. (PMID: 26643212) Trends Neurosci. 2019 Nov;42(11):778-792. (PMID: 31635851) Acta Neuropathol. 2017 Sep;134(3):441-458. (PMID: 28685323) Brain Behav Immun. 2016 Jul;55:114-125. (PMID: 26231972) CNS Neurosci Ther. 2019 Dec;25(12):1290-1298. (PMID: 31733036) J Neuroinflammation. 2020 Feb 15;17(1):57. (PMID: 32061255) Neuroscience. 2017 Feb 20;343:423-433. (PMID: 27998778) J Neuroinflammation. 2021 Mar 17;18(1):74. (PMID: 33731174) J Neurosci. 2014 Feb 5;34(6):2231-43. (PMID: 24501362) Neuroscience. 2006;139(3):991-7. (PMID: 16527422) Front Cell Dev Biol. 2021 Feb 18;9:629503. (PMID: 33681208) Neuroscience. 2009 Sep 15;162(4):1011-22. (PMID: 19447164) World J Psychiatry. 2015 Mar 22;5(1):15-34. (PMID: 25815252) Neurosci Lett. 2007 Mar 26;415(2):154-8. (PMID: 17240063) Prostaglandins Leukot Essent Fatty Acids. 2018 Aug;135:63-73. (PMID: 30103935) Cells. 2020 Dec 26;10(1):. (PMID: 33375263) Exp Neurol. 2012 Mar;234(1):220-9. (PMID: 22227060) Brain Behav Immun. 2014 Oct;41:22-31. (PMID: 24735929) Brain Behav Immun. 2020 Nov;90:81-96. (PMID: 32755645) Brain Behav Immun. 2016 Jul;55:126-137. (PMID: 26576722) J Perinat Med. 2008;36(1):5-14. (PMID: 18184094) J Neuroinflammation. 2020 Apr 2;17(1):98. (PMID: 32241286) Nat Neurosci. 2013 Sep;16(9):1211-1218. (PMID: 23872599) Neuropsychopharmacology. 2021 Feb;46(3):579-602. (PMID: 32781459) J Neurosci Res. 2014 Jun;92(6):723-31. (PMID: 24510633) Nat Genet. 2015 Jul;47(7):699-701. (PMID: 26111510) Neurosci Lett. 1988 Feb 29;85(2):169-71. (PMID: 3374833) Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):251-61. (PMID: 18060754) Am J Physiol Endocrinol Metab. 2013 Jun 15;304(12):E1391-403. (PMID: 23632634) Nutrients. 2021 Apr 02;13(4):. (PMID: 33918517) Front Immunol. 2020 Apr 03;11:430. (PMID: 32318054) Neurochem Int. 2019 Nov;130:104331. (PMID: 30423423) Semin Cell Dev Biol. 2019 Oct;94:129-137. (PMID: 30954657) J Cogn Neurosci. 2010 Aug;22(8):1662-9. (PMID: 19583478) Neural Plast. 2016;2016:3597209. (PMID: 27840741) Early Hum Dev. 1980 Jun;4(2):121-9. (PMID: 7408742) Prostaglandins Leukot Essent Fatty Acids. 2016 Nov;114:1-10. (PMID: 27926457) Brain. 2018 Jan 1;141(1):85-98. (PMID: 29244098) Biomolecules. 2021 Jul 20;11(7):. (PMID: 34356682) Glia. 2016 May;64(5):826-39. (PMID: 26847266) Prostaglandins Leukot Essent Fatty Acids. 2015 Jan;92:23-31. (PMID: 24972878) Front Physiol. 2021 Jun 03;12:682091. (PMID: 34149458) Curr Pharm Des. 2009;15(36):4103-16. (PMID: 20041812) Nat Rev Immunol. 2016 Sep;16(9):553-65. (PMID: 27396447) Brain Behav Immun. 2020 Mar;85:162-169. (PMID: 31100369) Neurosci Lett. 2020 Jan 1;714:134539. (PMID: 31614181) Nat Rev Neurol. 2019 Aug;15(8):447-458. (PMID: 31256193) Neuroscientist. 2020 Feb;26(1):74-86. (PMID: 30845892) Neuropsychopharmacology. 2015 Feb;40(3):525-36. (PMID: 25228141) Diabetologia. 2005 Nov;48(11):2365-75. (PMID: 16205884) Brain Behav Immun. 2018 Oct;73:427-440. (PMID: 29879442) Cell Res. 2013 Jul;23(7):962-4. (PMID: 23649315) J Neurosci. 2007 Nov 7;27(45):12132-8. (PMID: 17989279) PLoS Biol. 2010 Nov 02;8(11):e1000527. (PMID: 21072242) J Exp Med. 2015 Apr 6;212(4):481-95. (PMID: 25779633) J Anat. 1979 Jun;128(Pt 4):847-58. (PMID: 489472) Lipids. 1990 Sep;25(9):505-16. (PMID: 2250586) Cell Death Differ. 2011 Nov;18(11):1746-56. (PMID: 21566659) J Nutr. 2005 Sep;135(9):2241-6. (PMID: 16140905) Nat Commun. 2020 Nov 30;11(1):6133. (PMID: 33257673) Prog Lipid Res. 2016 Jul;63:132-52. (PMID: 27216485) J Neurol Sci. 2009 Nov 15;286(1-2):76-80. (PMID: 19625027) J Nutr. 2006 Jun;136(6):1570-5. (PMID: 16702323) Front Immunol. 2020 Mar 20;11:493. (PMID: 32265936) Reprod Nutr Dev. 2005 Sep-Oct;45(5):535-47. (PMID: 16188206) Cell Rep. 2020 Aug 18;32(7):108047. (PMID: 32814050) J Neuroinflammation. 2019 Apr 16;16(1):87. (PMID: 30992040) EMBO J. 2019 Sep 2;38(17):e101997. (PMID: 31373067) Nat Neurosci. 2011 Mar;14(3):345-50. (PMID: 21278728) Front Cell Neurosci. 2018 Nov 13;12:412. (PMID: 30483062) Brain Behav. 2013 Sep;3(5):503-14. (PMID: 24392271) Nutrients. 2011 May;3(5):529-54. (PMID: 22254110) Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):259-69. (PMID: 16963244) Front Cell Neurosci. 2020 Apr 07;14:79. (PMID: 32317939) J Neurochem. 2009 Oct;111(2):510-21. (PMID: 19682204) Curr Opin Cell Biol. 2021 Dec;73:105-109. (PMID: 34455405) |
| معلومات مُعتمدة: | MR/V032925/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: electron microscopy; microglia; myelin; n-3 PUFA; neurodevelopment |
| تواريخ الأحداث: | Date Created: 20220228 Latest Revision: 20240313 |
| رمز التحديث: | 20240313 |
| مُعرف محوري في PubMed: | PMC8866569 |
| DOI: | 10.3389/fncel.2022.802411 |
| PMID: | 35221920 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1662-5102 |
|---|---|
| DOI: | 10.3389/fncel.2022.802411 |