دورية أكاديمية
أعرض في EDS

Sex Disparities in the Association of Serum Uric Acid With Kidney Stone: A Cross-Sectional Study in China.

التفاصيل البيبلوغرافية
العنوان: Sex Disparities in the Association of Serum Uric Acid With Kidney Stone: A Cross-Sectional Study in China.
المؤلفون: Xu JZ; Department of Urology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Lu JL; Department of Urology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.; Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China., Hu L; Health Management Center, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Xun Y; Department of Urology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Wan ZC; Health Management Center, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Xia QD; Department of Urology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Qian XY; Department of Urology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Yang YY; Department of Urology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Hong SY; Department of Urology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Lv YM; Health Management Center, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Wang SG; Department of Urology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Lei XM; Health Management Center, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Guan W; Department of Urology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China., Li C; Department of Urology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
المصدر: Frontiers in medicine [Front Med (Lausanne)] 2022 Feb 09; Vol. 9, pp. 774351. Date of Electronic Publication: 2022 Feb 09 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2014]-
مستخلص: Background and Aims: Urolithiasis is characterized by high rates of prevalence and recurrence. Hyperuricemia is related to various diseases. We hope to determine the association between serum uric acid (UA) level and kidney stone (KS).
Methods: In this population-based cross-sectional study, a total of 82,017 Chinese individuals who underwent a comprehensive examination in 2017 were included. The KS was diagnosed based on ultrasonography examination outcomes. Fully adjusted odds ratio ( OR ) for KS, and mean difference between the two groups were applied to determine the association of UA level with KS.
Results: Among the 82,017 participants included in this study (aged 18~99 years), 9,435 participants (11.5%) are diagnosed with KS. A proportion of 56.3% of individuals is male. The mean UA level of overall participants is 341.77 μmol/L. The participants with KS report higher UA level than the participants without KS [mean UA level 369.91 vs. 338.11 μmol/L; mean difference (MD), 31.96 (95% CI , 29.61~34.28) μmol/L]. In men, the OR for KS significantly increases from 330 μmol/L UA level. Every 50 μmol/L elevation of UA level increases the risk of KS formation by about 10.7% above the UA level of 330 μmol/L in men. The subgroup analysis for male is consistent with the overall result except for the participants presenting underweight [adjusted OR , 1.035 (0.875~1.217); MD, -5.57 (-16.45~11.37)], low cholesterol [adjusted OR , 1.088 (0.938~1.261); MD, 8.18 (-7.93~24.68)] or high estimated glomerular filtration rate (eGFR) [adjusted OR , 1.044 (0.983~1.108); MD, 5.61 (-1.84~13.36)]. However, no significant association is observed in women between UA and KS either in all female participants or in female subgroups.
Conclusion: Among Chinese adults, UA level is associated with KS in a dose-response manner in men but not in women. However, the association becomes considerably weak in male participants with malnutrition status.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Xu, Lu, Hu, Xun, Wan, Xia, Qian, Yang, Hong, Lv, Wang, Lei, Guan and Li.)
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فهرسة مساهمة: Keywords: cross-sectional study; kidney stone; malnutrition; restricted cubic splines; sex disparities; uric acid
تواريخ الأحداث: Date Created: 20220228 Latest Revision: 20220502
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8864179
DOI: 10.3389/fmed.2022.774351
PMID: 35223892
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-858X
DOI:10.3389/fmed.2022.774351