دورية أكاديمية
Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice.
| العنوان: | Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice. |
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| المؤلفون: | Kim YJ; Laboratory of Developmental Biology and Genomics, BK21 Program for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; The Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 08826 Seoul, Republic of Korea., Kim HJ; The Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 08826 Seoul, Republic of Korea., Lee SG; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 08826 Seoul, Republic of Korea., Kim DH; Laboratory of Developmental Biology and Genomics, BK21 Program for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; The Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 08826 Seoul, Republic of Korea., In Jang S; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 08826 Seoul, Republic of Korea., Go HS; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 08826 Seoul, Republic of Korea., Lee WJ; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 08826 Seoul, Republic of Korea., Seong JK; Laboratory of Developmental Biology and Genomics, BK21 Program for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; The Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 08826 Seoul, Republic of Korea; Interdisciplinary Program for Bioinformatics, Program for Cancer Biology, BIO-MAX/N-Bio Institute, Seoul National University, 08826 Seoul, Republic of Korea. Electronic address: snumouse@snu.ac.kr. |
| المصدر: | Metabolism: clinical and experimental [Metabolism] 2022 May; Vol. 130, pp. 155178. Date of Electronic Publication: 2022 Feb 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Elsevier Inc. Original Publication: New York, Grune & Stratton. |
| مواضيع طبية MeSH: | Cardiovascular Diseases*/metabolism , Insulin Resistance* , Noncommunicable Diseases* , Physical Conditioning, Animal*, Adipose Tissue/metabolism ; Animals ; Diet, High-Fat/adverse effects ; Humans ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Motor Activity ; Obesity/metabolism ; Stress, Physiological |
| مستخلص: | Background: The relationship between exercise training and health benefits is under thorough investigation. However, the effects of exercise training on the maintenance of metabolic health are unclear. Methods: Our experimental design involved initial exercise training followed by a high-fat diet (HFD) challenge. Eight-week-old male was trained under voluntary wheel running aerobic exercise for eight weeks to determine the systemic metabolic changes induced by exercise training and whether such changes persisted even after discontinuing exercise. The mice were given either a normal chow diet (NCD) or HFD ad libitum for one week after discontinuation of exercise (CON-NCD, n = 29; EX-NCD, n = 29; CON-HFD, n = 30; EX-HFD, n = 31). Results: Our study revealed that metabolic stress following the transition to an HFD in mice that discontinued training failed to reverse the aerobic exercise training-induced improvement in metabolism. We report that the mice subjected to exercise training could better counteract weight gain, adipose tissue hypertrophy, insulin resistance, fatty liver, and mitochondrial dysfunction in response to an HFD compared with untrained mice. This observation could be attributed to the fact that exercise enhances the browning of white fat, whole-body oxygen uptake, and heat generation. Furthermore, we suggest that the effects of exercise persist due to PPARα-FGF21-FGFR1 mechanisms, although additional pathways cannot be excluded and require further research. Although our study suggests the preventive potential of exercise, appropriate human trials are needed to demonstrate the efficacy in subjects who cannot perform sustained exercise; this may provide an important basis regarding human health. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Adipose tissue; Energy expenditure; Exercise; Glucose homeostasis; Obesity |
| تواريخ الأحداث: | Date Created: 20220301 Date Completed: 20220428 Latest Revision: 20220428 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.metabol.2022.155178 |
| PMID: | 35227728 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-8600 |
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| DOI: | 10.1016/j.metabol.2022.155178 |