دورية أكاديمية
SARS-CoV-2 mRNA Vaccination and Graves' Disease: A Report of 12 Cases and Review of the Literature.
| العنوان: | SARS-CoV-2 mRNA Vaccination and Graves' Disease: A Report of 12 Cases and Review of the Literature. |
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| المؤلفون: | Chee YJ; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Liew H; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Hoi WH; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Lee Y; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Lim B; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Chin HX; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Lai RTR; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Koh Y; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Tham M; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Seow CJ; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Quek ZH; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Chen AW; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Quek TPL; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Tan AWK; Department of Endocrinology, Tan Tock Seng Hospital, Singapore., Dalan R; Department of Endocrinology, Tan Tock Seng Hospital, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore. |
| المصدر: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 May 17; Vol. 107 (6), pp. e2324-e2330. |
| نوع المنشور: | Case Reports; Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| مواضيع طبية MeSH: | COVID-19*/prevention & control , COVID-19 Vaccines*/adverse effects , Graves Disease*/chemically induced, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Recurrence ; Vaccination/adverse effects ; Vaccines, Synthetic/adverse effects ; Young Adult ; mRNA Vaccines |
| مستخلص: | Context and Objective: Thyroid autoimmunity has been reported to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the SARS-CoV-2 vaccination recently. We report a series of patients who presented with new onset or relapse of Graves' disease-related hyperthyroidism shortly after receiving the SARS-CoV-2 messenger RNA (mRNA) vaccine at a single tertiary institution in Singapore. Methods and Results: We describe 12 patients who developed hyperthyroidism within a relatively short interval (median onset, 17 [range, 5-63] days) after receiving the SARS-CoV-2 mRNA vaccine. The majority were females (11/12) with median age of 35.5 (range, 22-74) years. Six patients had new-onset hyperthyroidism, whereas the other 6 had relapse of previously well-controlled Graves' disease. TSH receptor antibody concentrations ranged from 2.4 to 32 IU/L. The majority of the patients were able to go for the second dose of the vaccine without any further exacerbations. Literature review revealed 21 other similar cases reported from across the world. Conclusion: Our case series provides insight into the characteristics of individuals in whom Graves' disease was triggered by the SARS-CoV-2 vaccination. Clinicians need to be vigilant of precipitation or exacerbation of autoimmune thyroid disorders in predisposed individuals after exposure to the SARS-CoV-2 vaccination. Further epidemiological and mechanistic studies are required to elucidate the possible associations between the SARS-CoV-2 vaccines and the development of thyroid autoimmunity. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| معلومات مُعتمدة: | MOH-000014 Ministry of Health, Clinician Scientist |
| فهرسة مساهمة: | Keywords: Graves’ disease; SARS-CoV-2 vaccine; hyperthyroidism |
| المشرفين على المادة: | 0 (COVID-19 Vaccines) 0 (Vaccines, Synthetic) |
| تواريخ الأحداث: | Date Created: 20220302 Date Completed: 20220519 Latest Revision: 20231213 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8903505 |
| DOI: | 10.1210/clinem/dgac119 |
| PMID: | 35235663 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-7197 |
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| DOI: | 10.1210/clinem/dgac119 |