دورية أكاديمية
أعرض في EDS

Evaluation of Antimicrobial Susceptibility Profile in Salmonella Typhi and Salmonella Paratyphi A: Presenting the Current Scenario in India and Strategy for Future Management.

التفاصيل البيبلوغرافية
العنوان: Evaluation of Antimicrobial Susceptibility Profile in Salmonella Typhi and Salmonella Paratyphi A: Presenting the Current Scenario in India and Strategy for Future Management.
المؤلفون: Veeraraghavan B; Christian Medical College, Vellore, India., Pragasam AK; Christian Medical College, Vellore, India., Ray P; Post Graduate Institute of Medical & Educational Research, Chandigarh, India., Kapil A; All India Institute of Medical Sciences, Delhi, India., Nagaraj S; St Johns Medical College, Bengaluru, India., Perumal SPB; Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India., Saigal K; Chacha Nehru Bal Chikitsalaya, Delhi, India., Thomas M; Christian Medical College, Ludhiana, India., Gupta M; Post Graduate Institute of Medical & Educational Research, Chandigarh, India., Rongsen-Chandola T; Centre for Health Research & Development-Society for Applied Studies, New Delhi, India., Jinka DR; Rural Development Trust Hospital, Bathalapalli, Andhra Pradesh, India., Shastri J; Topiwala National Medical College & BYL Nair Charitable Hospital, Mumbai, India., Alexander AP; Lady Willingdon Hospital, Manali, India., Koshy RM; Makunda Christian Leprosy & General Hospital, Karimjang, India., De A; Topiwala National Medical College & BYL Nair Charitable Hospital, Mumbai, India., Singh A; Chinchpada Christian Hospital, Nandurbar, India., Evelyn Ebenezer S; Duncan Hospital, Raxaul, India., Dutta S; ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India., Bavdekar A; KEM Hospital & Research Centre, Pune, India., More D; Centre for Health Research & Development-Society for Applied Studies, New Delhi, India., Sanghavi S; KEM Hospital & Research Centre, Pune, India., Nayakanti RR; Rural Development Trust Hospital, Bathalapalli, Andhra Pradesh, India., Jacob JJ; Christian Medical College, Vellore, India., Amladi A; Christian Medical College, Vellore, India., Anandan S; Christian Medical College, Vellore, India., Abirami BS; Christian Medical College, Vellore, India., Bakthavatchalam YD; Christian Medical College, Vellore, India., Sethuvel DPM; Christian Medical College, Vellore, India., John J; Christian Medical College, Vellore, India., Kang G; Christian Medical College, Vellore, India.
المصدر: The Journal of infectious diseases [J Infect Dis] 2021 Nov 23; Vol. 224 (Supple 5), pp. S502-S516.
نوع المنشور: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
مواضيع طبية MeSH: Salmonella paratyphi A* , Typhoid Fever*/drug therapy , Typhoid Fever*/epidemiology, Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azithromycin/pharmacology ; Azithromycin/therapeutic use ; Ceftriaxone/pharmacology ; Ceftriaxone/therapeutic use ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use ; Drug Resistance, Bacterial ; Humans ; India/epidemiology ; Microbial Sensitivity Tests ; Salmonella typhi
مستخلص: Background: Systematic studies to estimate the disease burden of typhoid and paratyphoid in India are limited. Therefore, a multicenter study on the Surveillance of Enteric Fever in India was carried out to estimate the incidence, clinical presentation, and antimicrobial resistance (AMR) trend. The data presented here represent the national burden of AMR in Salmonella Typhi and Salmonella Paratyphi A.
Methods: Antimicrobial susceptibility testing was performed for S. Typhi and S. Paratyphi A (n = 2373) isolates collected prospectively during a 2-year period from November 2017 to January 2020.
Results: Of 2373 Salmonella isolates, 2032 (85.6%) were identified as S. Typhi and 341 (14.4%) were S. Paratyphi A. Approximately 2% of S. Typhi were multidrug-resistant (MDR), whereas all 341 (100%) of S. Paratyphi A isolates were sensitive to the first-line antimicrobials. Among 98% of ciprofloxacin nonsusceptible isolates, resistance (minimum inhibitory concentration [MIC] >0.5 µg/mL) was higher in S. Typhi (37%) compared with S. Paratyphi A (20%). Azithromycin susceptibility was 99.9% and 100% with a mean MIC of 4.98 μg/mL for S. Typhi and 7.39 μg/mL for S. Paratyphi A respectively. Ceftriaxone was the only agent that retained 100% susceptibility. Moreover, beta-lactam/beta-lactamase inhibitors showed potent in vitro activity against the study isolates.
Conclusions: Data obtained from this systematic surveillance study confirms the declining trend of MDR Salmonella isolates from India. The higher prevalence of ciprofloxacin nonsusceptibility enforces to limit its use and adhere to the judicious usage of azithromycin and ceftriaxone for enteric fever management.
(© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)
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فهرسة مساهمة: Keywords: India; antimicrobial resistance; ciprofloxacin; surveillance; typhoid fever
المشرفين على المادة: 0 (Anti-Bacterial Agents)
5E8K9I0O4U (Ciprofloxacin)
75J73V1629 (Ceftriaxone)
83905-01-5 (Azithromycin)
تواريخ الأحداث: Date Created: 20220303 Date Completed: 20220509 Latest Revision: 20220509
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8892543
DOI: 10.1093/infdis/jiab144
PMID: 35238369
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-6613
DOI:10.1093/infdis/jiab144