دورية أكاديمية
Gene Therapy for Neuropsychiatric Disorders: Potential Targets and Tools.
| العنوان: | Gene Therapy for Neuropsychiatric Disorders: Potential Targets and Tools. |
|---|---|
| المؤلفون: | Shahcheraghi SH; Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.; Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Ayatollahi J; Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Lotfi M; Abortion Research Center, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Aljabali AAA; Department of Pharmaceutics & Pharmaceutical Technology, Yarmouk University, Irbid, Jordan., Al-Zoubi MS; Yarmouk University, Faculty of Medicine, Department of Basic Medical Sciences, Irbid, Jordan., Panda PK; Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, 75120 Uppsala, Sweden., Mishra V; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India., Satija S; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India., Charbe NB; Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX 78363, USA., Serrano-Aroca Á; Biomaterials and Bioengineering Lab, Translational Research Centre San Alberto Magno, Catholic University of Valencia San Vicente Mártir, C/Guillem de Castro 94, 46001 Valencia, Spain., Bahar B; Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport & Health Sciences, University of Central Lancashire, Preston, PR1 2HE, UK., Takayama K; Center for IPS Cell Research and Application, Kyoto University, Kyoto, 606-8397, Japan., Goyal R; Neuropharmacology Laboratory, School of Pharmaceutical Sciences, Shoolini University, Post Box No. 9, Solan, Himachal Pradesh 173212, India., Bhatia A; Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Punjab 151001, India., Almutary AG; Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Saudi Arabia., Alnuqaydan AM; Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Saudi Arabia., Mishra Y; Shri Shakti Degree College, Sankhahari, Ghatampur 209206, India., Negi P; Shoolini University of Biotechnology and Management Sciences, Solan 173 212, India., Courtney A; School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, United Kingdom., McCarron PA; School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, United Kingdom., Bakshi HA; School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, United Kingdom., Tambuwala MM; School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, United Kingdom. |
| المصدر: | CNS & neurological disorders drug targets [CNS Neurol Disord Drug Targets] 2023; Vol. 22 (1), pp. 51-65. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101269155 Publication Model: Print Cited Medium: Internet ISSN: 1996-3181 (Electronic) Linking ISSN: 18715273 NLM ISO Abbreviation: CNS Neurol Disord Drug Targets Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E.; San Francisco, CA : Bentham Science Publishers, c2006- |
| مواضيع طبية MeSH: | Genetic Therapy* , Mental Disorders*/genetics , Mental Disorders*/therapy, Humans |
| مستخلص: | Neuropsychiatric disorders that affect the central nervous system cause considerable pressures on the health care system and have a substantial economic burden on modern societies. The present treatments based on available drugs are mostly ineffective and often costly. The molecular process of neuropsychiatric disorders is closely connected to modifying the genetic structures inherited or caused by damage, toxic chemicals, and some current diseases. Gene therapy is presently an experimental concept for neurological disorders. Clinical applications endeavor to alleviate the symptoms, reduce disease progression, and repair defective genes. Implementing gene therapy in inherited and acquired neurological illnesses entails the integration of several scientific disciplines, including virology, neurology, neurosurgery, molecular genetics, and immunology. Genetic manipulation has the power to minimize or cure illness by inducing genetic alterations at endogenous loci. Gene therapy that involves treating the disease by deleting, silencing, or editing defective genes and delivering genetic material to produce therapeutic molecules has excellent potential as a novel approach for treating neuropsychiatric disorders. With the recent advances in gene selection and vector design quality in targeted treatments, gene therapy could be an effective approach. This review article will investigate and report the newest and the most critical molecules and factors in neuropsychiatric disorder gene therapy. Different genome editing techniques available will be evaluated, and the review will highlight preclinical research of genome editing for neuropsychiatric disorders while also evaluating current limitations and potential strategies to overcome genome editing advancements. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Neuropsychiatric disorders; autism; bipolar disorder; bloodbrain barrier; gene therapy; genes; molecular targets; therapeutics |
| تواريخ الأحداث: | Date Created: 20220307 Date Completed: 20221231 Latest Revision: 20230321 |
| رمز التحديث: | 20240628 |
| DOI: | 10.2174/1871527321666220304153719 |
| PMID: | 35249508 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!