دورية أكاديمية
أعرض في EDS

A novel concept of human antiviral protection: It's all about RNA (Review).

التفاصيل البيبلوغرافية
العنوان: A novel concept of human antiviral protection: It's all about RNA (Review).
المؤلفون: Aripova T; Institute of Immunology and Human Genomics, Academy of Sciences of Uzbekistan, Tashkent 100060, Uzbekistan., Muratkhodjaev J; Institute of Immunology and Human Genomics, Academy of Sciences of Uzbekistan, Tashkent 100060, Uzbekistan.; GENEX LLC Pharmaceutical Company, Tashkent 100052, Uzbekistan.
المصدر: Biomedical reports [Biomed Rep] 2022 Apr; Vol. 16 (4), pp. 29. Date of Electronic Publication: 2022 Feb 18.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: [Spandidos Publications] Country of Publication: England NLM ID: 101613227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2049-9442 (Electronic) Linking ISSN: 20499434 NLM ISO Abbreviation: Biomed Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : [Spandidos Publications], [2013]-
مستخلص: The comparative analysis of the antiviral protective mechanisms, including protozoa and RNA interference in multicellular organisms, has revealed their similarity and provided a basic understanding of adaptive immunity. The present article summarizes the latest studies on RNA-guided gene regulation in human antiviral protection, and its importance. Additionally, the role of both neutralizing antibodies and the interferon system in viral invasion is considered. The interferon system is an additional mechanism for suppressing viral infections in humans, which shifts cells into an 'alarm' mode to attempt to prevent further contagion. The primary task of the human central immune system is to maintain integrity and to protect against foreign organisms. In this review, a novel concept is proposed: Antiviral protection in all organisms can be achieved through an intracellular RNA-guided mechanism. A simple and effective defence against viruses is incorporation of a part of a virus's DNA (spacer) into the hosts chromosomes. Following reinfection, RNA transcripts of this spacer are created to direct nuclease enzymes to destroy the viral genome. This is an example of real-time adaptive immunity potentially possessed by every cell with a full complement of chromosomes, and an indicator that antiviral immunity is not only mediated by the presence of neutralizing antibodies and memory B- and T-cells, but also by the presence of specific spacers in the DNA of individuals who have recovered from a viral infection.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2020, Spandidos Publications.)
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فهرسة مساهمة: Keywords: COVID-19; CRISPR-Cas; RNA-I; SARS-CoV-2 spacers; antiviral immunity; interferon
تواريخ الأحداث: Date Created: 20220307 Latest Revision: 20231103
رمز التحديث: 20231103
مُعرف محوري في PubMed: PMC8889527
DOI: 10.3892/br.2022.1512
PMID: 35251616
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-9442
DOI:10.3892/br.2022.1512