دورية أكاديمية
Ebola Entry Inhibitors Discovered from Maesa perlarius .
العنوان: | Ebola Entry Inhibitors Discovered from Maesa perlarius . |
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المؤلفون: | Tsang NY; Teaching and Research Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China., Li WF; Teaching and Research Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China., Varhegyi E; Department of Microbiology and Immunology, College of Medicine, University of Illinois Chicago, 909 South Wolcott Ave, Chicago, IL 60612, USA., Rong L; Department of Microbiology and Immunology, College of Medicine, University of Illinois Chicago, 909 South Wolcott Ave, Chicago, IL 60612, USA., Zhang HJ; Teaching and Research Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2022 Feb 27; Vol. 23 (5). Date of Electronic Publication: 2022 Feb 27. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Catechin*/chemistry , Catechin*/pharmacology , Ebolavirus* , HIV Fusion Inhibitors*/pharmacology , Hemorrhagic Fever, Ebola*/drug therapy , Maesa*, Molecular Docking Simulation ; Plant Extracts/chemistry ; Plant Extracts/pharmacology |
مستخلص: | Ebola virus disease (EVD), a disease caused by infection with Ebola virus (EBOV), is characterized by hemorrhagic fever and a high case fatality rate. With limited options for the treatment of EVD, anti-Ebola viral therapeutics need to be urgently developed. In this study, over 500 extracts of medicinal plants collected in the Lingnan region were tested against infection with Ebola-virus-pseudotyped particles (EBOVpp), leading to the discovery of Maesa perlarius as an anti-EBOV plant lead. The methanol extract (MPBE) of the stems of this plant showed an inhibitory effect against EBOVpp, with an IC |
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معلومات مُعتمدة: | HKBU 12103917 The Research Grants Council of the Hong Kong Special Administrative Region, China; HKBU 12103618 The Research Grants Council of the Hong Kong Special Administrative Region, China; AI77767 National Institutes of Health (NIH) |
فهرسة مساهمة: | Keywords: EGCG; Maesa perlarius; anti-Ebola virus activity; condensed tannin; flavan-3-ol; procyanidin |
المشرفين على المادة: | 0 (HIV Fusion Inhibitors) 0 (Plant Extracts) 8R1V1STN48 (Catechin) |
تواريخ الأحداث: | Date Created: 20220310 Date Completed: 20220408 Latest Revision: 20220408 |
رمز التحديث: | 20240829 |
مُعرف محوري في PubMed: | PMC8910447 |
DOI: | 10.3390/ijms23052620 |
PMID: | 35269770 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
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DOI: | 10.3390/ijms23052620 |