دورية أكاديمية
Ebola Entry Inhibitors Discovered from Maesa perlarius .
| العنوان: | Ebola Entry Inhibitors Discovered from Maesa perlarius . |
|---|---|
| المؤلفون: | Tsang NY; Teaching and Research Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China., Li WF; Teaching and Research Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China., Varhegyi E; Department of Microbiology and Immunology, College of Medicine, University of Illinois Chicago, 909 South Wolcott Ave, Chicago, IL 60612, USA., Rong L; Department of Microbiology and Immunology, College of Medicine, University of Illinois Chicago, 909 South Wolcott Ave, Chicago, IL 60612, USA., Zhang HJ; Teaching and Research Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2022 Feb 27; Vol. 23 (5). Date of Electronic Publication: 2022 Feb 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مواضيع طبية MeSH: | Catechin*/chemistry , Catechin*/pharmacology , Ebolavirus* , HIV Fusion Inhibitors*/pharmacology , Hemorrhagic Fever, Ebola*/drug therapy , Maesa*, Molecular Docking Simulation ; Plant Extracts/chemistry ; Plant Extracts/pharmacology |
| مستخلص: | Ebola virus disease (EVD), a disease caused by infection with Ebola virus (EBOV), is characterized by hemorrhagic fever and a high case fatality rate. With limited options for the treatment of EVD, anti-Ebola viral therapeutics need to be urgently developed. In this study, over 500 extracts of medicinal plants collected in the Lingnan region were tested against infection with Ebola-virus-pseudotyped particles (EBOVpp), leading to the discovery of Maesa perlarius as an anti-EBOV plant lead. The methanol extract (MPBE) of the stems of this plant showed an inhibitory effect against EBOVpp, with an IC |
| References: | Bioorg Med Chem. 2004 Sep 15;12(18):4783-90. (PMID: 15336256) ACS Med Chem Lett. 2020 Jul 23;11(8):1653-1658. (PMID: 32832035) Acta Chim Slov. 2015;62(3):555-64. (PMID: 26454589) J Virol. 1995 Nov;69(11):6705-11. (PMID: 7474080) Mol Nutr Food Res. 2008 Jan;52(1):79-104. (PMID: 18081206) J Med Chem. 2018 Feb 8;61(3):724-733. (PMID: 29272110) Drug Metabol Drug Interact. 2000;17(1-4):237-59. (PMID: 11201298) J Med Chem. 2019 Mar 28;62(6):2928-2937. (PMID: 30785281) Cochrane Database Syst Rev. 2012 Apr 18;(4):CD008294. (PMID: 22513958) Phytochemistry. 1996 Jan;41(1):269-77. (PMID: 8588869) SLAS Discov. 2018 Mar;23(3):225-241. (PMID: 29460707) J Med Chem. 2018 Jun 14;61(11):4938-4945. (PMID: 29741894) J Nat Prod. 2020 Mar 27;83(3):770-803. (PMID: 32162523) Bioorg Med Chem Lett. 2014 May 15;24(10):2263-6. (PMID: 24745965) J Nutr. 2000 Aug;130(8S Suppl):2086S-92S. (PMID: 10917927) J Antivir Antiretrovir. 2011 Jan 7;3:8-10. (PMID: 22140608) Food Funct. 2015 Jan;6(1):32-41. (PMID: 25418533) J Nat Prod. 2017 Jun 23;80(6):1798-1807. (PMID: 28613071) J Nat Prod. 1999 Jul;62(7):954-8. (PMID: 10425115) Int J Mol Sci. 2015 Nov 24;16(11):27978-87. (PMID: 26610490) Virology. 1995 Feb 1;206(2):935-44. (PMID: 7531918) Pharmaceuticals (Basel). 2018 Jul 10;11(3):. (PMID: 29996481) J Nat Prod. 2001 Jan;64(1):82-4. (PMID: 11170672) Viruses. 2018 Mar 27;10(4):. (PMID: 29584652) J Comput Chem. 2010 Jan 30;31(2):455-61. (PMID: 19499576) PLoS Pathog. 2021 Feb 4;17(2):e1009312. (PMID: 33539432) Chin J Nat Med. 2019 Dec;17(12):945-952. (PMID: 31882050) Phytochemistry. 1997 Feb;44(3):491-5. (PMID: 9014372) Antiviral Res. 2014 Sep;109:171-4. (PMID: 25017472) Molecules. 2017 Nov 17;22(11):. (PMID: 29149072) J Nat Prod. 1988 Nov-Dec;51(6):1226-31. (PMID: 3069959) Phytochemistry. 2017 Apr;136:94-100. (PMID: 28110956) Phytochemistry. 1999 Nov;52(6):1121-31. (PMID: 10643673) J Agric Food Chem. 2003 Jun 18;51(13):3806-13. (PMID: 12797747) Sci Rep. 2017 Dec 15;7(1):17623. (PMID: 29247197) Nature. 2016 Jul 7;535(7610):169-172. (PMID: 27362232) J Agric Food Chem. 2010 Nov 24;58(22):11667-72. (PMID: 20964424) Nat Protoc. 2006;1(3):1112-6. (PMID: 17406391) Future Virol. 2009;4(6):621-635. (PMID: 20198110) |
| معلومات مُعتمدة: | HKBU 12103917 The Research Grants Council of the Hong Kong Special Administrative Region, China; HKBU 12103618 The Research Grants Council of the Hong Kong Special Administrative Region, China; AI77767 National Institutes of Health (NIH) |
| فهرسة مساهمة: | Keywords: EGCG; Maesa perlarius; anti-Ebola virus activity; condensed tannin; flavan-3-ol; procyanidin |
| المشرفين على المادة: | 0 (HIV Fusion Inhibitors) 0 (Plant Extracts) 8R1V1STN48 (Catechin) |
| تواريخ الأحداث: | Date Created: 20220310 Date Completed: 20220408 Latest Revision: 20220408 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC8910447 |
| DOI: | 10.3390/ijms23052620 |
| PMID: | 35269770 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!