دورية أكاديمية

In-depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: A case series study.

التفاصيل البيبلوغرافية
العنوان: In-depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: A case series study.
المؤلفون: Astley C; Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.; Rheumatology Division, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Badue Pereira MF; Chidren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Lima MS; Nuclear Medicine Division, Department of Radiology and Oncology, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Buchpiguel CA; Nuclear Medicine Division, Department of Radiology and Oncology, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Carneiro CG; Nuclear Medicine Division, Department of Radiology and Oncology, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Sapienza MT; Nuclear Medicine Division, Department of Radiology and Oncology, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Leal GN; Chidren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., do Prado DML; Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil., Peçanha T; Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil., Sieczkowska SM; Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil., Matsuo OM; Chidren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Lindoso L; Chidren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Marques HH; Chidren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Silva CA; Chidren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Gualano B; Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.; Rheumatology Division, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.; Food Research Center, University of Sao Paulo, Sao Paulo, Brazil.
المصدر: Physiological reports [Physiol Rep] 2022 Mar; Vol. 10 (5), pp. e15201.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013-
مواضيع طبية MeSH: COVID-19*/complications , Cardiovascular System*, Child ; Female ; Humans ; Male ; Positron Emission Tomography Computed Tomography ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
مستخلص: We assessed PET-CT myocardial blood flow (MBF) using N-13 ammonia, brachial flow-mediated dilation, and cardiopulmonary exercise test in five post-discarged MIS-C survivors. None of the patients (median age: 9, range: 7-18 years; 3 females; 2 males) had preexisting pediatric chronic conditions. At the follow-up visit, two patients exhibited severe perfusion defect developed in the left ventricular cavity, suggesting extensive myocardial ischemia (MBF <2.0) and one patient showed persistent mild pericardial effusion. Others two patients demonstrated endothelial dysfunction. Nevertheless, all patients had lower predicted values in the VO 2peak , VO 2VAT , OUES, and O 2 Pulse (range: 35.2%-64.5%; 15.6%-38.2%; 1.0-1.3 L/min; 4-7 ml/beat), respectively. Our d suggested that previously health MIS-C patients had impaired MBF, endothelial dysfunction and lower cardiopulmonary capacity at follow-up analysis. Multidisciplinary further investigations should be conducted to reinforce these findings.
(© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
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معلومات مُعتمدة: 303422/2015-7 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 88887.509598/2020-00 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 2015/03756-4 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2017/13552-2 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2019/15231-4 Fundação de Amparo à Pesquisa do Estado de São Paulo
فهرسة مساهمة: Keywords: COVID-19; MIS-C; cardiovascular imaging; children; inflammation
SCR Disease Name: pediatric multisystem inflammatory disease, COVID-19 related
تواريخ الأحداث: Date Created: 20220311 Date Completed: 20220404 Latest Revision: 20220405
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8915155
DOI: 10.14814/phy2.15201
PMID: 35274818
قاعدة البيانات: MEDLINE
الوصف
تدمد:2051-817X
DOI:10.14814/phy2.15201