Cross-protection, infection and case fatality rates in wild European rabbits experimentally challenged with different rabbit haemorrhagic disease viruses.

التفاصيل البيبلوغرافية
العنوان:	Cross-protection, infection and case fatality rates in wild European rabbits experimentally challenged with different rabbit haemorrhagic disease viruses.
المؤلفون:	Patel KK; Department of Primary Industries and Regions (PIRSA), Biosecurity, Urrbrae, South Australia, Australia.; School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.; Centre for Invasive Species Solutions, Australian Capital Territory, Bruce, Australia., Strive T; Centre for Invasive Species Solutions, Australian Capital Territory, Bruce, Australia.; Health & Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Acton, Australian Capital Territory, Australia., Hall RN; Centre for Invasive Species Solutions, Australian Capital Territory, Bruce, Australia.; Health & Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Acton, Australian Capital Territory, Australia., Mutze G; Department of Primary Industries and Regions (PIRSA), Biosecurity, Urrbrae, South Australia, Australia., Page B; Department of Primary Industries and Regions (PIRSA), Biosecurity, Urrbrae, South Australia, Australia.; Centre for Invasive Species Solutions, Australian Capital Territory, Bruce, Australia., Korcz M; Department of Primary Industries and Regions (PIRSA), Biosecurity, Urrbrae, South Australia, Australia., Booth-Remmers M; Department of Primary Industries and Regions (PIRSA), Biosecurity, Urrbrae, South Australia, Australia.; Australian Wildlife Conservancy, Subiaco, Western Australia, Australia., Smith IL; Centre for Invasive Species Solutions, Australian Capital Territory, Bruce, Australia., Huang N; Centre for Invasive Species Solutions, Australian Capital Territory, Bruce, Australia.; Health & Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Acton, Australian Capital Territory, Australia., Kovaliski J; Department of Primary Industries and Regions (PIRSA), Biosecurity, Urrbrae, South Australia, Australia.; Centre for Invasive Species Solutions, Australian Capital Territory, Bruce, Australia., Jayasinghe Ellakkala Appuhamilage RMJ; Department of Primary Industries and Regions (PIRSA), Biosecurity, Urrbrae, South Australia, Australia.; Centre for Invasive Species Solutions, Australian Capital Territory, Bruce, Australia., Taggart PL; School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.; Centre for Invasive Species Solutions, Australian Capital Territory, Bruce, Australia.; Department of Primary Industries NSW, Vertebrate Pest Research Unit, Queanbeyan, New South Wales, Australia.
المصدر:	Transboundary and emerging diseases [Transbound Emerg Dis] 2022 Sep; Vol. 69 (5), pp. e1959-e1971. Date of Electronic Publication: 2022 Apr 01.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Blackwell Verlag Country of Publication: Germany NLM ID: 101319538 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-1682 (Electronic) Linking ISSN: 18651674 NLM ISO Abbreviation: Transbound Emerg Dis Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Berlin : Blackwell Verlag
مواضيع طبية MeSH:	Caliciviridae Infections/veterinary , Hemorrhagic Disease Virus, Rabbit , Lagovirus*, Animals ; Phylogeny ; Rabbits ; Seroepidemiologic Studies
مستخلص:	Rabbit haemorrhagic disease virus 2 (RHDV2) is now the dominant calicivirus circulating in wild rabbit populations in Australia. This study compared the infection and case fatality rates of RHDV2 and two RHDVs in wild rabbits, as well as their ability to overcome immunity to the respective other strains. Wild rabbits were allocated to groups either blindly or based on pre-screening for RHDV/RHDV2 antibodies at capture. Rabbits were monitored regularly until their death or humane killing at 7 days post infection. Liver and eyeball samples were collected for lagovirus testing and aging rabbits, respectively. At capture, rabbits showed high seroprevalence to RHDV2 but not to RHDV. In RHDV/RHDV2 seronegative rabbits at capture, infection rates were highest in those inoculated with RHDV2 (81.8%, 18 out of 22), followed by K5 (53.8%, seven out of 13) and CZECH (40.0%, two out of five), but these differences were not statistically significant. In rabbits with previous exposure to RHDV2 at capture, infection rates were highest when inoculated with K5 (59.6%, 31 out of 52) followed by CZECH (46.0%, 23 out of 50), with infection rates higher in younger rabbits for both viruses. In RHDV/RHDV2 seronegative rabbits at capture, case fatality rates were highest for those inoculated with K5 (71.4%), followed by RHDV2 (50.0%) and CZECH (50.0%). In rabbits with previous exposure to RHDV2 at capture, case fatality rates were highest in rabbits inoculated with K5 (12.9%) followed by CZECH (8.7%), with no case fatalities following RHDV2 inoculation. Case fatality rates did not differ significantly between inoculums in either serostatus group at capture. Based on multivariable modelling, time to death post RHDV inoculation increased in rabbits with recent RHDV2 exposure compared with seronegative rabbits and with age. The results suggest that RHDV2 may cause higher mortalities than other variants in seronegative rabbit populations but that K5 may be more effective in reducing rabbit populations in an RHDV2-dominant landscape. (© 2022 Wiley-VCH GmbH.)
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فهرسة مساهمة:	Keywords: Oryctolagus cuniculus; case fatality; lagovirus; rabbit biocontrol; rabbit haemorrhagic disease; survival
تواريخ الأحداث:	Date Created: 20220322 Date Completed: 20220929 Latest Revision: 20220929
رمز التحديث:	20240628
DOI:	10.1111/tbed.14530
PMID:	35315981
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1865-1682
DOI:	10.1111/tbed.14530