دورية أكاديمية
Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity.
| العنوان: | Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity. |
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| المؤلفون: | Hamed Almurisi S; Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan 25200, Malaysia., Al-Japairai K; Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, Gambang 26300, Malaysia., Alshammari F; Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia., Alheibshy F; Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia.; Department of Pharmaceutics, College of Pharmacy, Aden University, Aden 6075, Yemen., Sammour RMF; Pharmaceutics Department, Dubai Pharmacy College for Girls, Dubai 19099, United Arab Emirates., Doolaanea AA; Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan 25200, Malaysia.; IKOP Sdn Bhd, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Malaysia. |
| المصدر: | Gels (Basel, Switzerland) [Gels] 2022 Feb 25; Vol. 8 (3). Date of Electronic Publication: 2022 Feb 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101696925 Publication Model: Electronic Cited Medium: Internet ISSN: 2310-2861 (Electronic) Linking ISSN: 23102861 NLM ISO Abbreviation: Gels Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2015]- |
| مستخلص: | The stability of the medicinal product is a major concern in the pharmaceutical industry and health authorities, whose goal is to guarantee that drugs are delivered to patients without loss of therapeutic properties. This study aims to evaluate the effect of environmental conditions and packaging on the stability of paracetamol instant jelly sachets based on both chemical and physical stability. The paracetamol instant jelly was packaged in plastic sachets (packaging 1) and sealed aluminium bags in screw-capped amber glass bottles (packaging 2), which were stored in real-time and accelerated stability chambers for 3 months. Samples were taken out from the chambers and were characterised for appearance, moisture content, texture, viscosity, in vitro drug release, paracetamol content, and 4-aminophenol level at different time points. The real-time storage condition at a lower temperature maintained the stability of the paracetamol instant jelly, while the accelerated condition led to a significant change in the formulation properties. In addition, the proper packaging of paracetamol instant jelly maintained the paracetamol's stability, regardless of environmental conditions, for three months. The results show that the environmental conditions and packaging play a significant role in maintaining paracetamol instant jelly stability. |
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| معلومات مُعتمدة: | P-RIGS18-026-0026 International Islamic University Malaysia |
| فهرسة مساهمة: | Keywords: environmental conditions; packaging; paracetamol; shelf life; stability |
| تواريخ الأحداث: | Date Created: 20220324 Latest Revision: 20220329 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8950020 |
| DOI: | 10.3390/gels8030144 |
| PMID: | 35323257 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2310-2861 |
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| DOI: | 10.3390/gels8030144 |