دورية أكاديمية
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis.
| العنوان: | Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis. |
|---|---|
| المؤلفون: | Oliveira JT; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Dakic V; L'Oréal Research & Innovation, Rio de Janeiro, Brazil., Vitória G; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Pedrosa CDSG; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Mendes M; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Aragão LGHS; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Cardim-Pires TR; Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Lelièvre D; EPISKIN SA, Lyon, France., Furtado DR; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil., Pinheiro RO; Leprosy Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil., Foguel D; Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Breton L; L'Oréal Research & Innovation, Aulnay-sous-bois, France., Bouez C; L'Oréal Research & Innovation, Clark, NJ, USA., De Vecchi R; L'Oréal Research & Innovation, Rio de Janeiro, Brazil., Guimarães MZP; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Rehen S; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. Electronic address: srehen@lance-ufrj.org. |
| المصدر: | Neurobiology of aging [Neurobiol Aging] 2022 May; Vol. 113, pp. 108-117. Date of Electronic Publication: 2022 Feb 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Elsevier Original Publication: Fayetteville, N.Y. : Ankho International. |
| مواضيع طبية MeSH: | Tumor Necrosis Factor-alpha*/metabolism , alpha-Synuclein*/metabolism, Aged ; Epidermis/metabolism ; Epidermis/pathology ; Humans ; Inflammation/metabolism ; Keratinocytes/metabolism |
| مستخلص: | Aged and photoaged skin exhibit fine wrinkles that are signs of epidermal inflammation and degeneration. It has been shown that healthy elderly skin expresses amyloidogenic proteins, including α-Synuclein, which are known to oligomerize and trigger inflammation and neurodegeneration. However, little is known about their putative role in skin physiology and sensitivity. To unravel this possible role, we investigated the impact of oligomeric α-Synuclein (Oα-Syn) in 2D and 3D keratinocyte human models. Exogenous Oα-Syn caused degeneration of reconstructed human epidermis (RHE) by diminishing proliferation and thickness of the stratum basale. Oα-Syn also increased NF-kB nuclear translocation in keratinocytes and triggered inflammation in the RHE, by increasing expression of interleukin-1β and tumor necrosis factor-alpha, and the release of tumor necrosis factor-alpha in a time-dependent manner. Dexamethasone and an IL-1β inhibitor partially diminished RHE degeneration caused by Oα-Syn. These findings suggest that Oα-Syn induces epidermal inflammation and decreases keratinocyte proliferation, and therefore might contribute to epidermal degeneration observed in human skin aging. Competing Interests: Disclosure statement VD and RDV are employees of L'Oréal Research & Innovation. The authors declare that there are no conflicts of interest. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Epidermis; Inflammaging; Neurodegeneration; Skin degeneration; α-Synuclein |
| المشرفين على المادة: | 0 (Tumor Necrosis Factor-alpha) 0 (alpha-Synuclein) |
| تواريخ الأحداث: | Date Created: 20220324 Date Completed: 20220425 Latest Revision: 20220512 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.neurobiolaging.2022.02.010 |
| PMID: | 35325812 |
| قاعدة البيانات: | MEDLINE |
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