دورية أكاديمية
Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS).
| العنوان: | Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS). |
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| المؤلفون: | Ashfaq M; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan., Shah S; Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan., Rasul A; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan., Hanif M; Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60000, Pakistan., Khan HU; Department of Pharmaceutics, College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan., Khames A; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif 21944, Saudi Arabia., Abdelgawad MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Ghoneim MM; Department of Pharmacy Practice, Faculty of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia., Ali MY; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan., Abourehab MAS; Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Minia University, Minia 61519, Egypt., Maheen S; Department of Pharmaceutics, College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan., Iqbal O; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan., Abbas G; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan., El Sisi AM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt. |
| المصدر: | Pharmaceutics [Pharmaceutics] 2022 Feb 22; Vol. 14 (3). Date of Electronic Publication: 2022 Feb 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مستخلص: | The purpose of the study was to develop an SNEDDS to improve the solubility and bioavailability of pitavastatin. The solubility of pitavastatin in different oils, surfactants, and co-surfactants was determined and a pseudo-ternary phase diagram was constructed. The SNEDDS was characterized by zeta-sizer, zeta-potential, FTIR, DSC, and TGA. Release and permeation of pitavastatin from the SNEDDS was studied for 12 and 24 h, respectively. The lipolysis test, RBC lysis, effect on lipid profile, and pharmacokinetics were studied. The SPC3 formulation showed a 104 ± 1.50 nm particle size, a 0.198 polydispersity index (PDI), and a -29 zeta potential. FTIR, DSC, and TGA showed the chemical compatibility and thermal stability. The release and permeation of pitavastatin from SPC3 was 88.5 ± 2.5% and 96%, respectively. In the lipolysis test, the digestion of SPC3 yielded a high amount of pitavastatin and showed little RBC lysis. The lipid profile suggested that after 35 days of administration of the SNEDDS, there was a marked decrease in TC, LDL, and triglyceride levels. The SNEDDS of SPC3 showed an 86% viability of Caco-2 cells. Pharmacokinetics of SPC3 showed improved values of C |
| References: | J Pharm Pharmacol. 2012 Mar;64(3):326-36. (PMID: 22309264) Drug Deliv. 2015;22(6):765-84. (PMID: 24673611) Res Pharm Sci. 2019 Oct 04;14(5):378-390. (PMID: 31798654) Colloids Surf B Biointerfaces. 2013 Dec 1;112:337-43. (PMID: 24012665) Int J Nanomedicine. 2014 Oct 07;9:4685-95. (PMID: 25336948) Pharmaceuticals (Basel). 2021 Aug 25;14(9):. (PMID: 34577546) Br J Clin Pharmacol. 2005 Mar;59(3):291-7. (PMID: 15752374) Eur J Pharm Biopharm. 2012 Feb;80(2):289-97. (PMID: 22119666) J Pharm (Cairo). 2014;2014:801820. (PMID: 26556202) FASEB J. 2019 Dec;33(12):13710-13721. (PMID: 31585508) J Pharm Sci. 2003 Dec;92(12):2386-98. (PMID: 14603484) Eur J Pharm Sci. 2007 Jun;31(2):85-94. (PMID: 17418543) Int J Nanomedicine. 2015 Jul 03;10:4293-307. (PMID: 26170665) Int J Pharm. 2015 Apr 10;483(1-2):77-88. (PMID: 25666025) Eur J Pharm Sci. 2015 Jul 10;74:1-10. (PMID: 25845633) Prev Chronic Dis. 2013 Apr 25;10:E64. (PMID: 23618544) Pharmaceutics. 2019 Mar 19;11(3):. (PMID: 30893852) Pharmaceutics. 2020 Aug 10;12(8):. (PMID: 32785007) Spectrochim Acta A Mol Biomol Spectrosc. 2010 Mar;75(3):1078-81. (PMID: 20060777) Atherosclerosis. 2002 Jun;162(2):373-9. (PMID: 11996957) Eur J Pharm Biopharm. 2009 Aug;72(3):539-45. (PMID: 19298857) J Young Pharm. 2011 Jan;3(1):4-8. (PMID: 21607048) Pharmaceutics. 2018 Dec 19;10(4):. (PMID: 30572636) Eur J Pharm Sci. 2008 Nov 15;35(4):257-63. (PMID: 18706499) Front Pharmacol. 2019 May 02;10:459. (PMID: 31118895) Biomed Res Int. 2019 Jan 29;2019:4870350. (PMID: 30834266) Cardiovasc Res. 2010 Jul 15;87(2):385-93. (PMID: 20045866) Nanomedicine. 2016 Aug;12(6):1431-43. (PMID: 27033463) Biomaterials. 2003 Mar;24(7):1121-31. (PMID: 12527253) Pharmacology. 2003 Aug;68(4):169-76. (PMID: 12837970) Rev Cardiovasc Med. 2018 Sep 30;19(3):77-88. (PMID: 31054556) |
| فهرسة مساهمة: | Keywords: cytotoxicity; drug release; nanoemulsion; pharmacokinetics; pitavastatin |
| تواريخ الأحداث: | Date Created: 20220326 Latest Revision: 20220329 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8953816 |
| DOI: | 10.3390/pharmaceutics14030482 |
| PMID: | 35335860 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1999-4923 |
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| DOI: | 10.3390/pharmaceutics14030482 |