دورية أكاديمية
Quercetin and Quercitrin from Agrimonia pilosa Ledeb Inhibit the Migration and Invasion of Colon Cancer Cells through the JNK Signaling Pathway.
| العنوان: | Quercetin and Quercitrin from Agrimonia pilosa Ledeb Inhibit the Migration and Invasion of Colon Cancer Cells through the JNK Signaling Pathway. |
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| المؤلفون: | Trinh NT; Department of Biochemistry, Dongguk University College of Oriental Medicine, Gyeongju 38066, Korea., Nguyen TMN; Department of Biochemistry, Dongguk University College of Oriental Medicine, Gyeongju 38066, Korea., Yook JI; Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea., Ahn SG; Department of Pathology, Chosun University College of Dentistry, Gwangju 61452, Korea., Kim SA; Department of Biochemistry, Dongguk University College of Oriental Medicine, Gyeongju 38066, Korea. |
| المصدر: | Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Mar 17; Vol. 15 (3). Date of Electronic Publication: 2022 Mar 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c2004- |
| مستخلص: | Considering the high metastatic potential of colorectal cancer (CRC), the inhibition of metastasis is important for anti-CRC therapy. Agrimonia pilosa Ledeb ( A. pilosa ) is a perennial herbaceous plant that is widely distributed in Asia. The extracts of A. pilosa have shown diverse pharmacological properties, such as antimicrobial, anti-inflammatory, and antitumor activities. In the present study, the antimetastatic activity of A. pilosa was evaluated. Methanol extraction from the roots of A. pilosa was performed by high-performance liquid chromatography (HPLC) and 12 fractions were obtained. Among these, fraction 4 showed the most potent inhibitory effect on the migration of colon cancer cells. Using LC-HR MS analysis, quercetin and quercitrin were identified as flavonoids contained in fraction 4. Like fraction 4, quercetin and quercitrin effectively inhibited the migration and invasion of RKO cells. While the level of E-cadherin was increased, the levels of N-cadherin and vimentin were decreased by the same agents. Although they all activate the p38, JNK, and ERK signaling pathways, only SP600125, an inhibitor of the JNK pathway, specifically inhibited the effect of fraction 4, quercetin, and quercitrin on cell migration. An in vivo experiment also confirmed the antitumor activity of quercetin and quercitrin. Collectively, these results suggest that A. pilosa and its two flavonoids, quercetin and quercitrin, are candidates for the antimetastatic treatment of CRC. |
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| معلومات مُعتمدة: | 2020R1F1A1071179 Korea government (MSIT) |
| فهرسة مساهمة: | Keywords: Agrimonia pilosa Ledeb; JNK; colon cancer; invasion; migration; quercetin; quercitrin |
| تواريخ الأحداث: | Date Created: 20220326 Latest Revision: 20220328 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8951172 |
| DOI: | 10.3390/ph15030364 |
| PMID: | 35337161 |
| قاعدة البيانات: | MEDLINE |
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