دورية أكاديمية
Multifunctional 99m Tc-5-azacitidine Gold Nanoparticles: Formulation, In Vitro Cytotoxicity, Radiosynthesis, and In Vivo Pharmacokinetic Study.
| العنوان: | Multifunctional 99m Tc-5-azacitidine Gold Nanoparticles: Formulation, In Vitro Cytotoxicity, Radiosynthesis, and In Vivo Pharmacokinetic Study. |
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| المؤلفون: | Eldin SSE; Department of Radiation Protection, Nuclear and Radiation Safety Research Center, Egyptian Atomic Energy Authority, Cairo 13759, Egypt., Rashed HM; Department of Labeled Compounds, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo 13759, Egypt.; Department of Pharmaceutics, Faculty of Pharmacy, Sinai University, Kantara, Egypt., Hassan AH; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt., Salem HF; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt., Sakr TM; Department of Radioactive Isotopes and Generator, Hot Laboratories Centre, Egyptian Atomic Energy Authority, Cairo 13759, Egypt. |
| المصدر: | Current drug delivery [Curr Drug Deliv] 2023; Vol. 20 (4), pp. 387-399. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101208455 Publication Model: Print Cited Medium: Internet ISSN: 1875-5704 (Electronic) Linking ISSN: 15672018 NLM ISO Abbreviation: Curr Drug Deliv Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2004- |
| مواضيع طبية MeSH: | Gold*/chemistry , Metal Nanoparticles*/chemistry, Mice ; Animals ; Azacitidine/pharmacology ; Tissue Distribution ; Radiopharmaceuticals ; Technetium/chemistry ; Technetium/pharmacology |
| مستخلص: | Background: 5-azacitidine is a very potent chemotherapeutic agent that suffers from certain disadvantages. Objective: This study aims to prepare gold nanoparticles as a new nano-formula of 5-azacitidine that can improve its bioavailability and decrease its side effects. Methods: 5-azacytidine-loaded GA-AuNPs were prepared and characterized by UV-Vis spectroscopy, infrared (IR), and electronic transmission microscope (TEM). This new platform was characterized in vitro by measuring its zeta potential, particle size, and drug loading efficacy, and the anti-proliferative effect on the MCF-7 cell line was evaluated. In vivo biodistribution studies of 99m Tc-5-aza solution and 99m Tc-5-aza-gold nano formula were conducted in tumor-bearing mice by different routes of administration (intravenous and intra-tumor). Results: 5-Aza-GA-AuNPs formula was successfully prepared with an optimum particle size of ≈34.66 nm, the zeta potential of -14.4 mV, and high entrapment efficiency. 99m Tc-5-Aza-GA-AuNPs were successfully radiosynthesized with a labeling yield of 95.4%. Biodistribution studies showed high selective accumulation in tumor and low uptake in non-target organs in the case of the 5-Aza-GA-AuNPs formula than the 99m Tc-5-azacitidine solution. Conclusion: 99m Tc-5-Aza-GA-AuNPs improved the selectivity and uptake of 5-azacitidine in cancer. Moreover, 99m Tc-5-Aza-GA-AuNPs could be used as hopeful theranostic radiopharmaceutical preparation for cancer. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: 5-azacytidine; Gold nanoparticles; cancer chemotherapeutics; side effects; technetium-99m; theranostic radiopharmaceuticals |
| المشرفين على المادة: | 7440-57-5 (Gold) M801H13NRU (Azacitidine) 0 (Radiopharmaceuticals) 7440-26-8 (Technetium) |
| تواريخ الأحداث: | Date Created: 20220327 Date Completed: 20230310 Latest Revision: 20230310 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2174/1567201819666220325092122 |
| PMID: | 35339176 |
| قاعدة البيانات: | MEDLINE |
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