دورية أكاديمية
[The Basic Research of Antigen-antibody Reaction in Lung Transplantation].
| العنوان: | [The Basic Research of Antigen-antibody Reaction in Lung Transplantation]. |
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| المؤلفون: | Suzuki H; Department of General Thoracic Surgery, Chiba University, Chiba, Japan., Hata A, Yamanaka T, Matsumoto H, Kaiho T, Shiina Y, Toyoda T, Ito T, Inage T, Tanaka K, Sakairi Y, Wada H, Iwata T, Motohashi S, Yoshida S, Yoshino I |
| المصدر: | Kyobu geka. The Japanese journal of thoracic surgery [Kyobu Geka] 2022 Apr; Vol. 75 (4), pp. 244-251. |
| نوع المنشور: | Journal Article |
| اللغة: | Japanese |
| بيانات الدورية: | Publisher: Nankodo Country of Publication: Japan NLM ID: 0413533 Publication Model: Print Cited Medium: Print ISSN: 0021-5252 (Print) Linking ISSN: 00215252 NLM ISO Abbreviation: Kyobu Geka Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tokyo : Nankodo Original Publication: Tokyo. |
| مواضيع طبية MeSH: | Graft Rejection*/prevention & control , Lung Transplantation*, Animals ; Antibodies ; Antigen-Antibody Reactions ; Humans ; Japan ; Mice |
| مستخلص: | Lung transplantation has become popular in Japan, showing better survival rate than other countries. However, the results are still not satisfactory compared with other solid organ transplantation. One of the reasons for this might be that knowledge on donor-specific antibodies or antibody-related rejection, which has been attracting attention these days, is less than that of kidney or liver transplantation. Our laboratory has continued basic research in this field using rodent lung transplantation model. We have previously shown that type V collagen is associated in chronic rejection as an autoimmune, and that oral administration of type V collagen induces tolerance. The murine chronic rejection model of the minor antigen mismatch was developed, and involvement of the humoral immunity and role of the complement activation were shown. We are now studying the effects of immune checkpoint molecules, which play a central role in the field of cancer therapy, on rejection after lung transplantation. We are also working to verify the effects of anti-complement drugs and molecular targeted drugs in the future treatment on rejection. |
| المشرفين على المادة: | 0 (Antibodies) |
| تواريخ الأحداث: | Date Created: 20220328 Date Completed: 20220331 Latest Revision: 20220401 |
| رمز التحديث: | 20221213 |
| PMID: | 35342153 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0021-5252 |
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