دورية أكاديمية
أعرض في EDS

Determining Losses in Jet Injection Subcutaneous Insulin Delivery: A Model-Based Approach.

التفاصيل البيبلوغرافية
العنوان: Determining Losses in Jet Injection Subcutaneous Insulin Delivery: A Model-Based Approach.
المؤلفون: McHugh AD; Centre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand., Chase JG; Centre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand., Knopp JL; Centre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand., Zhou T; Centre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand., Holder-Pearson L; Centre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.
المصدر: Journal of diabetes science and technology [J Diabetes Sci Technol] 2023 Jul; Vol. 17 (4), pp. 1016-1028. Date of Electronic Publication: 2022 Mar 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sage Country of Publication: United States NLM ID: 101306166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-2968 (Electronic) Linking ISSN: 19322968 NLM ISO Abbreviation: J Diabetes Sci Technol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : Thousand Oaks, CA : Sage
Original Publication: Foster City, CA : Diabetes Technology Society
مواضيع طبية MeSH: Insulin* , Insulin, Regular, Human*, Adult ; Humans ; Injections, Jet ; Injections, Subcutaneous ; Glucose Tolerance Test
مستخلص: Objective: Accurate, safe glycemic management requires reliable delivery of insulin doses. Insulin can be delivered subcutaneously for action over a longer period of time. Needle-free jet injectors provide subcutaneous (SC) delivery without requiring needle use, but the volume of insulin absorbed varies due to losses associated with the delivery method. This study employs model-based methods to determine the expected proportion of active insulin present from a needle-free SC dose.
Methods: Insulin, C-peptide, and glucose assay data from a frequently sampled insulin-modified oral glucose tolerance test trial with 2U SC insulin delivery, paired with a well-validated metabolic model, predict metabolic outcomes for N = 7 healthy adults. Subject-specific nonlinear hepatic clearance profiles are modeled over time using third-order basis splines with knots located at assay times. Hepatic clearance profiles are constrained within a physiological rate of change, and relative to plasma glucose profiles. Insulin loss proportions yielding optimal insulin predictions are then identified, quantifying delivery losses.
Results: Optimal parameter identification suggests losses of up to 22% of the nominal 2U SC dose. The degree of loss varies between subjects and between trials on the same subject. Insulin fit accuracy improves where loss greater than 5% is identified, relative to where delivery loss is not modeled.
Conclusions: Modeling shows needle-free SC jet injection of a nominal dose of insulin does not necessarily provide metabolic action equivalent to total dose, and this availability significantly varies between trials. By quantifying and accounting for variability of jet injection insulin doses, better glycemic management outcomes using SC jet injection may be achieved.
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فهرسة مساهمة: Keywords: OGTT; hepatic clearance; identification; identification error; insulin kinetics; insulin modified; jet injection; subcutaneous insulin
المشرفين على المادة: 0 (Insulin)
0 (Insulin, Regular, Human)
تواريخ الأحداث: Date Created: 20220328 Date Completed: 20230703 Latest Revision: 20230717
رمز التحديث: 20230717
مُعرف محوري في PubMed: PMC10347999
DOI: 10.1177/19322968221085032
PMID: 35343255
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-2968
DOI:10.1177/19322968221085032