دورية أكاديمية
Molluskicidal activity of 3-aryl-2-hydroxy-1,4-naphthoquinones against Biomphalaria glabrata.
| العنوان: | Molluskicidal activity of 3-aryl-2-hydroxy-1,4-naphthoquinones against Biomphalaria glabrata. |
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| المؤلفون: | Martins DL; Instituto de Química, Laboratório de Catálise e Síntese (LabCSI), Laboratório 413, Campus do Valonguinho, Centro, Outeiro de São João Batista s/n, Universidade Federal Fluminense, Niterói, RJ 24020-141, Brazil. Electronic address: dlmartins@id.uff.br., do Amaral E Silva NA; Instituto de Química, Laboratório de Catálise e Síntese (LabCSI), Laboratório 413, Campus do Valonguinho, Centro, Outeiro de São João Batista s/n, Universidade Federal Fluminense, Niterói, RJ 24020-141, Brazil., Ferreira VF; Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, R. Dr. Mario Vianna, 523 - Santa Rosa, Niterói, RJ 24241-002, Brazil., Rangel LDS; Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-360, Brazil; Postgraduate Program in Sciences and Biotechnology, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil., Dos Santos JAA; Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-360, Brazil., Faria RX; Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-360, Brazil; Postgraduate Program in Sciences and Biotechnology, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil. Electronic address: salvador@ioc.fiocruz.br. |
| المصدر: | Acta tropica [Acta Trop] 2022 Jul; Vol. 231, pp. 106414. Date of Electronic Publication: 2022 Mar 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6254 (Electronic) Linking ISSN: 0001706X NLM ISO Abbreviation: Acta Trop Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Basel. |
| مواضيع طبية MeSH: | Biomphalaria*/parasitology , Naphthoquinones*/pharmacology , Schistosomiasis* , Schistosomiasis mansoni*/drug therapy , Schistosomiasis mansoni*/parasitology, Animals ; Humans ; Niclosamide ; Schistosoma mansoni |
| مستخلص: | Schistosomiasis is the second most prevalent parasitic infectious disease after malaria, which affects millions of people worldwide and causes health and socioeconomic problems. The snail Biomphalaria glabrata is an intermediate host for the helminth, which is the causative agent of schistosomiasis: Schistosoma mansoni. One crucial strategy for controlling the disease is the eradication of the snail host. Niclosamide is the unique molluskicide applied in large-scale control programs, but its selectivity to other species is not adequate. Therefore, there is an urgent need to develop new molluskicides that are inexpensive, safe, and selective. Quinones are ubiquitous, playing important biological roles in fungi, plants, and others. Many synthetic molecules with relevant biological activities that contain the quinone nucleus in their structure are on the market in the therapy of cancer, malaria, or toxoplasmosis, for example. Derivatives of quinones are tools in the development of new molluskicides for Abbott laboratories. In the present work, 3-aryl-2‑hydroxy-1,4-naphthoquinones (ANs) were tested for molluskicide activity against Biomphalaria glabrata. The lethal concentration was determined for 48 h of continuous exposure. The naphthoquinones were found to have molluskicide properties. AN-15 was recorded as the highest mortality. Additionally, this analog exhibited in silico reduced ambient toxicity when compared to niclosamide. The findings of this study demonstrate that 3-aryl-2‑hydroxy-1,4-naphthoquinones are effective for the management of Biomphalaria glabrata under laboratory conditions. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Lawsone; Molluskicide; Quinones; Schistosoma; Schistosomiasis; Snail |
| المشرفين على المادة: | 0 (Naphthoquinones) 8KK8CQ2K8G (Niclosamide) TLH4A6LV1W (lawsone) |
| تواريخ الأحداث: | Date Created: 20220329 Date Completed: 20220525 Latest Revision: 20220525 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.actatropica.2022.106414 |
| PMID: | 35346667 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6254 |
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| DOI: | 10.1016/j.actatropica.2022.106414 |