دورية أكاديمية
Genetic variation of macronutrient tolerance in Drosophila melanogaster.
| العنوان: | Genetic variation of macronutrient tolerance in Drosophila melanogaster. |
|---|---|
| المؤلفون: | Havula E; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia. essi.havula@helsinki.fi.; School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW, 2006, Australia. essi.havula@helsinki.fi.; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. essi.havula@helsinki.fi., Ghazanfar S; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Lamichane N; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.; Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Francis D; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia., Hasygar K; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.; Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Liu Y; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.; Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Alton LA; School of Biological Sciences, Monash University, Melbourne, VIC, 3800, Australia., Johnstone J; School of Biological Sciences, Monash University, Melbourne, VIC, 3800, Australia., Needham EJ; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.; School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW, 2006, Australia., Pulpitel T; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia., Clark T; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia., Niranjan HN; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia., Shang V; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia., Tong V; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia., Jiwnani N; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia., Audia G; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia., Alves AN; School of Biological Sciences, Monash University, Melbourne, VIC, 3800, Australia., Sylow L; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Medical and Health Sciences, University of Copenhagen, 2200, Copenhagen, Denmark., Mirth C; School of Biological Sciences, Monash University, Melbourne, VIC, 3800, Australia., Neely GG; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.; School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW, 2006, Australia., Yang J; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.; School of Mathematics and Statistics, The University of Sydney, Camperdown, NSW, 2006, Australia., Hietakangas V; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.; Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Simpson SJ; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.; School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW, 2006, Australia., Senior AM; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia. alistair.senior@sydney.edu.au.; School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW, 2006, Australia. alistair.senior@sydney.edu.au.; School of Mathematics and Statistics, The University of Sydney, Camperdown, NSW, 2006, Australia. alistair.senior@sydney.edu.au. |
| المصدر: | Nature communications [Nat Commun] 2022 Mar 28; Vol. 13 (1), pp. 1637. Date of Electronic Publication: 2022 Mar 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Drosophila melanogaster*/metabolism, Animals ; DNA-Binding Proteins/metabolism ; Genetic Variation ; Nutrients ; Sugars/metabolism ; Transcription Factors/metabolism |
| مستخلص: | Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition. (© 2022. The Author(s).) |
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| المشرفين على المادة: | 0 (DNA-Binding Proteins) 0 (Drosophila Proteins) 0 (Sugars) 0 (Transcription Factors) 126968-14-7 (Eip75B protein, Drosophila) |
| تواريخ الأحداث: | Date Created: 20220329 Date Completed: 20220413 Latest Revision: 20221021 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8960806 |
| DOI: | 10.1038/s41467-022-29183-x |
| PMID: | 35347148 |
| قاعدة البيانات: | MEDLINE |
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