دورية أكاديمية
Influence of narrow-band ultraviolet B therapy on sirtuin 1 expression in lesional skin of patients with chronic plaque psoriasis: Relation to clinical improvement and interferon-γ expression.
| العنوان: | Influence of narrow-band ultraviolet B therapy on sirtuin 1 expression in lesional skin of patients with chronic plaque psoriasis: Relation to clinical improvement and interferon-γ expression. |
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| المؤلفون: | Eid AA; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Aly RG; Department of Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Elkholy SAE; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Sorour OA; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. |
| المصدر: | Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 2022 Nov; Vol. 38 (6), pp. 555-563. Date of Electronic Publication: 2022 Apr 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Country of Publication: England NLM ID: 9013641 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0781 (Electronic) Linking ISSN: 09054383 NLM ISO Abbreviation: Photodermatol Photoimmunol Photomed Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2010-> : Oxford : Blackwell Original Publication: Copenhagen : Munksgaard, c1990- |
| مواضيع طبية MeSH: | Ultraviolet Therapy* , Psoriasis*/metabolism , Graft vs Host Disease*, Humans ; Sirtuin 1/metabolism ; Sirtuin 1/therapeutic use ; Interferon-gamma ; Skin/pathology |
| مستخلص: | Background: Reduced sirtuin 1 (Sirt1) expression in psoriasis was previously reported, and its activation was associated with disease improvement. Narrow-band ultraviolet B (NB-UVB) downregulates several pro-inflammatory cytokines such as interferon-γ (IFN-γ) and influences keratinocyte differentiation in psoriasis. Objectives: The aim of this study was to study the in vivo influence NB-UVB treatment on Sirt1 expression in psoriatic skin in relation to disease improvement and IFN-γ expression. Methods: Twenty-six patients with chronic plaque psoriasis were evaluated, and psoriasis area severity index (PASI) was calculated. Skin biopsies were taken from lesional skin of the patients before and after 3 months of treatment with NB-UVB and from 26 controls, where the distribution and immunohistochemistry (IHC) scores of Sirt1 and IFN-γ were determined. Results: After 3 months of treatment, Sirt1 distribution and epidermal IHC score were significantly higher, whereas Sirt1 dermal IHC score and IFN-γ distribution, epidermal and dermal IHC scores were significantly lower than the pre-treatment values. Before and after 3 months of NB-UVB therapy, PASI showed a significant negative correlation with Sirt1 distribution and epidermal IHC score; and a significant positive correlation with interferon-γ distribution and epidermal IHC score. Moreover, Sirt1 distributions were negatively correlated with the corresponding interferon-γ distributions. Conclusions The detected upregulation of epidermal Sirt1 following NB-UVB therapy possibly represents another mechanism by which NB-UVB can act in psoriasis and also highlights the role of Sirt1 upregulation in psoriasis treatment. (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: IFN-γ; NB-UVB; Sirt1; psoriasis |
| المشرفين على المادة: | EC 3.5.1.- (Sirtuin 1) 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 20220330 Date Completed: 20221116 Latest Revision: 20221116 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/phpp.12790 |
| PMID: | 35353379 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1600-0781 |
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| DOI: | 10.1111/phpp.12790 |