دورية أكاديمية
The role of maternal age & birth order on the development of unilateral and bilateral retinoblastoma: a multicentre study.
| العنوان: | The role of maternal age & birth order on the development of unilateral and bilateral retinoblastoma: a multicentre study. |
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| المؤلفون: | Lloyd P; Barts and The London School of Medicine and Dentistry, London, E1 2AD, UK., Westcott M; The Royal London Hospital, Barts Health NHS Trust, London, E1 1FR, UK.; UCL Institute of Ophthalmology, London, EC1V 9EL, UK.; Moorfields Eye Hospital NHS Foundation Trust, London, EC1V 2PD, UK., Kaliki S; The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, 500034, India., Ji X; Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Zou Y; Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Rashid R; Ocular Oncology, Ispahani Islamia Eye Institute and Hospital, Dhaka, 1215, Bangladesh., Sultana S; Ocular Oncology, Ispahani Islamia Eye Institute and Hospital, Dhaka, 1215, Bangladesh., Sherief ST; Addis Ababa University, School of Medicine, Department of Ophthalmology, Addis Ababa, 3614, Ethiopia., Cassoux N; Institut Curie, Université de Paris Medicine Paris V Descartes, Paris, 75248, France., Diaz Coronado RY; Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru., Garcia Leon JL; Anglo American Clinic, Lima, 15073, Peru., López AMZ; Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru., Polyakov VG; Head and Neck Tumors Department, SRI of Pediatric Oncology and Hematology of N.N. Blokhin National Medical Research Center of Oncology of Russian Federation, and Medical Academy of Postgraduate Education, Moscow, 115478, Russia., Ushakova TL; Head and Neck Tumors Department, SRI of Pediatric Oncology and Hematology of N.N. Blokhin National Medical Research Center of Oncology of Russian Federation, and Medical Academy of Postgraduate Education, Moscow, 115478, Russia., Roy SR; Chittagong Eye Infirmary & Training Complex, Chittagong, 4202, Bangladesh., Ahmad A; The Children's Hospital & the Institute of Child Health, Lahore, 54000, Pakistan., Harby LA; The Royal London Hospital, Barts Health NHS Trust, London, E1 1FR, UK.; Moorfields Eye Hospital NHS Foundation Trust, London, EC1V 2PD, UK., Berry JL; Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, USA., Kim J; Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, USA., Polski A; Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, USA., Astbury NJ; International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK., Bascaran C; International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK., Blum S; Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, 52621, Israel., Bowman R; International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.; Ophthalmology Department, Great Ormond Street Children's Hospital, London, WC1N 3JH, UK., Burton MJ; International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK., Foster A; International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK., Gomel N; Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 39040, Israel., Keren-Froim N; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 39040, Israel., Madgar S; Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, 52621, Israel., Stacey AW; Department of Ophthalmology, University of Washington, Seattle, WA, 98195, USA., Mohamed A; Ophthalmic Biophysics (AMd), L V Prasad Eye Institute, Hyderabad, 500034, India., Zondervan M; International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK., Sagoo MS; The Royal London Hospital, Barts Health NHS Trust, London, E1 1FR, UK.; UCL Institute of Ophthalmology, London, EC1V 9EL, UK.; Moorfields Eye Hospital NHS Foundation Trust, London, EC1V 2PD, UK.; NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and UCL Institute of Ophthalmology and London Retinoblastoma Service, Royal London Hospital, London, EC1V 2PD, UK., Fabian ID; International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.; Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, 52621, Israel., Reddy MA; The Royal London Hospital, Barts Health NHS Trust, London, E1 1FR, UK. ashwin.reddy4@nhs.net.; Moorfields Eye Hospital NHS Foundation Trust, London, EC1V 2PD, UK. ashwin.reddy4@nhs.net.; Queen Mary University of London, London, E1 4NS, UK. ashwin.reddy4@nhs.net. |
| المصدر: | Eye (London, England) [Eye (Lond)] 2023 Apr; Vol. 37 (5), pp. 966-970. Date of Electronic Publication: 2022 Mar 31. |
| نوع المنشور: | Multicenter Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8703986 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5454 (Electronic) Linking ISSN: 0950222X NLM ISO Abbreviation: Eye (Lond) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: London : Nature Publishing Group Original Publication: [London : Ophthalmological Society of the United Kingdom, 1987- |
| مواضيع طبية MeSH: | Retinal Neoplasms*/epidemiology , Retinal Neoplasms*/genetics , Retinal Neoplasms*/pathology , Retinoblastoma*/epidemiology , Retinoblastoma*/genetics , Retinoblastoma*/pathology, Child ; Humans ; Birth Order ; Cohort Studies ; Maternal Age ; Retrospective Studies ; Risk Factors ; Female |
| مستخلص: | Background/objectives: Retinoblastoma is a common childhood intraocular malignancy, the bilateral form of which most commonly results from a de novo germline pathogenic variant in the RB1 gene. Both advanced maternal age and decreasing birth order are known to increase the risk of de novo germline pathogenic variants, while the influence of national wealth is understudied. This cohort study aimed to retrospectively observe whether these factors influence the ratio of bilateral retinoblastoma cases compared to unilateral retinoblastoma, thereby inferring an influence on the development of de novo germline pathogenic variants in RB1. Subjects/methods: Data from 688 patients from 11 centres in 10 countries were analysed using a series of statistical methods. Results: No associations were found between advanced maternal age, birth order or GDP per capita and the ratio of bilateral to unilateral retinoblastoma cases (p values = 0.534, 0.201, 0.067, respectively), indicating that these factors do not contribute to the development of a de novo pathogenic variant. Conclusions: Despite a lack of a definitive control group and genetic testing, this study demonstrates that advanced maternal age, birth order or GDP per capita do not influence the risk of developing a bilateral retinoblastoma. (© 2022. The Author(s).) |
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| معلومات مُعتمدة: | 207472/Z/17/Z United Kingdom WT_ Wellcome Trust; K08 CA232344 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20220401 Date Completed: 20230330 Latest Revision: 20240304 |
| رمز التحديث: | 20240305 |
| مُعرف محوري في PubMed: | PMC10050160 |
| DOI: | 10.1038/s41433-022-01992-w |
| PMID: | 35361938 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1476-5454 |
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| DOI: | 10.1038/s41433-022-01992-w |