دورية أكاديمية
أعرض في EDS

Matrix Metalloproteinase 2 and 9 Enzymatic Activities are Selectively Increased in the Myocardium of Chronic Chagas Disease Cardiomyopathy Patients: Role of TIMPs.

التفاصيل البيبلوغرافية
العنوان: Matrix Metalloproteinase 2 and 9 Enzymatic Activities are Selectively Increased in the Myocardium of Chronic Chagas Disease Cardiomyopathy Patients: Role of TIMPs.
المؤلفون: Baron MA; Laboratory of Immunology, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil.; Division of Clinical Immunology and Allergy, University of São Paulo, School of Medicine, São Paulo, Brazil.; Institute for Investigation in Immunology, Institutos Nacionais de Ciência e Tecnologia (INCT), São Paulo, Brazil., Ferreira LRP; Laboratory of Immunology, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil.; Division of Clinical Immunology and Allergy, University of São Paulo, School of Medicine, São Paulo, Brazil.; Institute for Investigation in Immunology, Institutos Nacionais de Ciência e Tecnologia (INCT), São Paulo, Brazil.; Department of Bioengineering, Universidade Santo Amaro, São Paulo, Brazil., Teixeira PC; Laboratory of Immunology, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil.; Division of Clinical Immunology and Allergy, University of São Paulo, School of Medicine, São Paulo, Brazil.; Institute for Investigation in Immunology, Institutos Nacionais de Ciência e Tecnologia (INCT), São Paulo, Brazil., Moretti AIS; Vascular Biology Laboratory, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil., Santos RHB; Division of Transplantation, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil., Frade AF; Laboratory of Immunology, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil.; Division of Clinical Immunology and Allergy, University of São Paulo, School of Medicine, São Paulo, Brazil.; Institute for Investigation in Immunology, Institutos Nacionais de Ciência e Tecnologia (INCT), São Paulo, Brazil., Kuramoto A; Laboratory of Immunology, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil.; Institute for Investigation in Immunology, Institutos Nacionais de Ciência e Tecnologia (INCT), São Paulo, Brazil., Debbas V; Department of Bioengineering, Universidade Santo Amaro, São Paulo, Brazil., Benvenuti LA; Division of Transplantation, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil., Gaiotto FA; Vascular Biology Laboratory, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil., Bacal F; Vascular Biology Laboratory, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil., Pomerantzeff P; Vascular Biology Laboratory, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil., Chevillard C; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR_1090, Aix Marseille Université, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa, Marseille, France., Kalil J; Division of Clinical Immunology and Allergy, University of São Paulo, School of Medicine, São Paulo, Brazil.; Institute for Investigation in Immunology, Institutos Nacionais de Ciência e Tecnologia (INCT), São Paulo, Brazil., Cunha-Neto E; Laboratory of Immunology, Heart Institute (InCor), University of São Paulo, School of Medicine, São Paulo, Brazil.; Division of Clinical Immunology and Allergy, University of São Paulo, School of Medicine, São Paulo, Brazil.; Institute for Investigation in Immunology, Institutos Nacionais de Ciência e Tecnologia (INCT), São Paulo, Brazil.
المصدر: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Mar 17; Vol. 12, pp. 836242. Date of Electronic Publication: 2022 Mar 17 (Print Publication: 2022).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media SA
مواضيع طبية MeSH: Cardiomyopathy, Dilated*/metabolism , Chagas Cardiomyopathy*, Humans ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Myocardium
مستخلص: Chronic Chagas disease (CCC) is an inflammatory dilated cardiomyopathy with a worse prognosis compared to other cardiomyopathies. We show the expression and activity of Matrix Metalloproteinases (MMP) and of their inhibitors TIMP (tissue inhibitor of metalloproteinases) in myocardial samples of end stage CCC, idiopathic dilated cardiomyopathy (DCM) patients, and from organ donors. Our results showed significantly increased mRNA expression of several MMPs, several TIMPs and EMMPRIN in CCC and DCM samples. MMP-2 and TIMP-2 protein levels were significantly elevated in both sample groups, while MMP-9 protein level was exclusively increased in CCC. MMPs 2 and 9 activities were also exclusively increased in CCC. Results suggest that the balance between proteins that inhibit the MMP-2 and 9 is shifted toward their activation. Inflammation-induced increases in MMP-2 and 9 activity and expression associated with imbalanced TIMP regulation could be related to a more extensive heart remodeling and poorer prognosis in CCC patients.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Baron, Ferreira, Teixeira, Moretti, Santos, Frade, Kuramoto, Debbas, Benvenuti, Gaiotto, Bacal, Pomerantzeff, Chevillard, Kalil and Cunha-Neto.)
References: Trends Parasitol. 2006 Dec;22(12):583-8. (PMID: 17049308)
J Vis Exp. 2010 Nov 08;(45):. (PMID: 21085107)
Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):372. (PMID: 15556929)
Lancet. 2010 Apr 17;375(9723):1388-402. (PMID: 20399979)
Can J Cardiol. 2006 Feb;22 Suppl B:25B-30B. (PMID: 16498509)
Exp Parasitol. 2014 Dec;147:72-80. (PMID: 25448360)
Int J Cardiol. 2011 Aug 18;151(1):18-33. (PMID: 20546954)
Pflugers Arch. 2014 Jun;466(6):1113-27. (PMID: 24519465)
Physiol Rev. 2007 Oct;87(4):1285-342. (PMID: 17928585)
Sci Rep. 2016 Jan 29;6:20171. (PMID: 26822129)
J Immunol. 2006 Sep 1;177(5):3193-200. (PMID: 16920958)
Clin Cardiol. 1987 Nov;10(11):665-70. (PMID: 3677499)
Int J Mol Sci. 2021 Mar 24;22(7):. (PMID: 33804922)
PLoS Negl Trop Dis. 2017 Jan 24;11(1):e0005284. (PMID: 28118356)
Braz J Med Biol Res. 2009 Mar;42(3):251-62. (PMID: 19287904)
Heart Fail Rev. 2014 Mar;19(2):227-36. (PMID: 23589353)
Acta Trop. 2010 Jul-Aug;115(1-2):5-13. (PMID: 20382097)
Cardiovasc Res. 2006 Feb 15;69(3):666-76. (PMID: 16426590)
Circulation. 2010 Dec 21;122(25):2727-35. (PMID: 21173361)
Matrix Biol. 2015 May-Jul;44-46:1-6. (PMID: 25916966)
Cardiovasc Ther. 2012 Feb;30(1):31-41. (PMID: 20645986)
Cardiovasc Res. 2006 Feb 15;69(3):562-73. (PMID: 16405877)
Cardiovasc Res. 2006 Feb 15;69(3):604-13. (PMID: 16360129)
Inflamm Res. 2016 Dec;65(12):941-949. (PMID: 27516211)
Curr Drug Targets Inflamm Allergy. 2005 Apr;4(2):177-81. (PMID: 15853739)
J Cardiovasc Pharmacol Ther. 2007 Mar;12(1):5-14. (PMID: 17495253)
Neth Heart J. 2008 Apr;16(4):129-33. (PMID: 18427637)
Glob Heart. 2015 Sep;10(3):173-80. (PMID: 26407513)
Cell Cycle. 2011 May 1;10(9):1448-55. (PMID: 21467843)
Cardiovasc Res. 2000 May;46(2):298-306. (PMID: 10773234)
Life Sci. 2004 Feb 6;74(12):1561-72. (PMID: 14729404)
Infect Immun. 2013 Oct;81(10):3600-8. (PMID: 23856618)
Am Heart J. 2013 Apr;165(4):558-66. (PMID: 23537973)
Ann Trop Med Parasitol. 2003 Mar;97(2):139-48. (PMID: 12803869)
Matrix Biol. 2015 May-Jul;44-46:138-46. (PMID: 25644103)
Cardiovasc Res. 2002 Mar;53(4):822-30. (PMID: 11922892)
Am J Pathol. 2017 May;187(5):1134-1146. (PMID: 28322201)
J Infect Dis. 2008 May 15;197(10):1468-76. (PMID: 18444803)
Biochem Pharmacol. 2014 Jul 1;90(1):7-15. (PMID: 24780447)
Heart. 2009 Mar;95(3):181-9. (PMID: 18977804)
J Mol Cell Cardiol. 2008 Jan;44(1):210-7. (PMID: 17869266)
J Renin Angiotensin Aldosterone Syst. 2006 Sep;7(3):162-7. (PMID: 17094053)
J Card Fail. 2012 Aug;18(8):654-9. (PMID: 22858082)
Biochim Biophys Acta. 2010 Jan;1803(1):55-71. (PMID: 20080133)
Circ Res. 2013 Aug 30;113(6):725-38. (PMID: 23989715)
Mediators Inflamm. 2013;2013:928315. (PMID: 23840100)
J Am Heart Assoc. 2015 Jan 23;4(1):e001359. (PMID: 25616975)
Am J Trop Med Hyg. 2015 Jan;92(1):39-44. (PMID: 25385865)
Annu Rev Pharmacol Toxicol. 2007;47:211-42. (PMID: 17129183)
Clin Infect Dis. 2017 Oct 1;65(7):1103-1111. (PMID: 28575239)
معلومات مُعتمدة: P50 AI098461 United States AI NIAID NIH HHS; U19 AI098461 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Chagas disease; MMP; cardiac remodeling; cardiomyopathy; fibrosis; heart failure; metalloproteinases
المشرفين على المادة: EC 3.4.24.24 (MMP2 protein, human)
EC 3.4.24.24 (Matrix Metalloproteinase 2)
EC 3.4.24.35 (MMP9 protein, human)
EC 3.4.24.35 (Matrix Metalloproteinase 9)
تواريخ الأحداث: Date Created: 20220404 Date Completed: 20220405 Latest Revision: 20220607
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8968914
DOI: 10.3389/fcimb.2022.836242
PMID: 35372112
قاعدة البيانات: MEDLINE
الوصف
تدمد:2235-2988
DOI:10.3389/fcimb.2022.836242