دورية أكاديمية
Easily-injectable shear-thinning hydrogel provides long-lasting submucosal barrier for gastrointestinal endoscopic surgery.
| العنوان: | Easily-injectable shear-thinning hydrogel provides long-lasting submucosal barrier for gastrointestinal endoscopic surgery. |
|---|---|
| المؤلفون: | Tang Y; Materials Science Institute, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China., Hu M; Department of Gastrointestinal Endoscopy, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China., Tang F; Department of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.; Institute of Biomedical Innovation and Laboratory of Regenerative Medicine and Biomaterials, Biomedical Material Conversion and Evaluation Engineering Technology Research Center of Guangdong Province, Guangzhou, 510655, China., Huang R; Department of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.; Institute of Biomedical Innovation and Laboratory of Regenerative Medicine and Biomaterials, Biomedical Material Conversion and Evaluation Engineering Technology Research Center of Guangdong Province, Guangzhou, 510655, China., Wang H; Department of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.; Institute of Biomedical Innovation and Laboratory of Regenerative Medicine and Biomaterials, Biomedical Material Conversion and Evaluation Engineering Technology Research Center of Guangdong Province, Guangzhou, 510655, China., Wu D; Materials Science Institute, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China., Lan P; Department of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.; Institute of Biomedical Innovation and Laboratory of Regenerative Medicine and Biomaterials, Biomedical Material Conversion and Evaluation Engineering Technology Research Center of Guangdong Province, Guangzhou, 510655, China. |
| المصدر: | Bioactive materials [Bioact Mater] 2021 Dec 20; Vol. 15, pp. 44-52. Date of Electronic Publication: 2021 Dec 20 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Ke Ai Publishing Country of Publication: China NLM ID: 101685294 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-199X (Electronic) Linking ISSN: 2452199X NLM ISO Abbreviation: Bioact Mater Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Ke Ai Publishing |
| مستخلص: | Submucosal injection material has shown protective effect against gastrointestinal injury during endoscopic surgery in clinic. However, the protective ability of existing submucosal injection material is strictly limited by their difficult injectability and short barrier time. Herein, we report a shear-thinning gellan gum hydrogel that simultaneously has easy injectability and long-lasting barrier function, together with good hemostatic property and biocompatibility. Shear-thinning property endows our gellan gum hydrogel with excellent endoscopic injection performance, and the injection pressure of our gellan gum hydrogel is much lower than that of the small molecule solution (50 wt% dextrose) when injected through the endoscopic needle. More importantly, our gellan gum hydrogel shows much stronger barrier retention ability than normal saline and sodium hyaluronate solution in the ex vivo and in vivo models. Furthermore, our epinephrine-containing gellan gum hydrogel has a satisfactory hemostatic effect in the mucosal lesion resection model of pig. These results indicate an appealing application prospect for gellan gum hydrogel utilizing as a submucosal injection material in endoscopic surgery. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Authors.) |
| References: | Bioact Mater. 2020 Oct 23;6(4):1150-1162. (PMID: 33134608) Gastroenterol Rep (Oxf). 2019 Apr;7(2):91-97. (PMID: 30976421) Sci Adv. 2021 Jun 2;7(23):. (PMID: 34078598) Arq Gastroenterol. 2010 Apr-Jun;47(2):184-7. (PMID: 20721465) Drug Des Devel Ther. 2009 Feb 06;2:131-8. (PMID: 19920900) Bioact Mater. 2021 Jul 06;8:196-209. (PMID: 34541396) Gastroenterol Rep (Oxf). 2014 Feb;2(1):1-15. (PMID: 24760231) Endoscopy. 2007 May;39(5):428-33. (PMID: 17516349) Gastrointest Endosc. 2008 Oct;68(4):692-8. (PMID: 18514651) Bioact Mater. 2021 May 23;6(12):4717-4728. (PMID: 34136722) Nat Rev Gastroenterol Hepatol. 2016 Aug;13(8):486-96. (PMID: 27353401) Gastrointest Endosc. 2005 Dec;62(6):943-5. (PMID: 16301041) Gastrointest Endosc. 2005 Dec;62(6):933-42. (PMID: 16301040) Cancers (Basel). 2021 Jun 24;13(13):. (PMID: 34202763) Endosc Int Open. 2020 May;8(5):E623-E627. (PMID: 32355880) Lancet Gastroenterol Hepatol. 2018 May;3(5):349-362. (PMID: 29644977) Acta Biomater. 2014 Mar;10(3):1251-8. (PMID: 24345554) Int J Pharm. 2014 Nov 20;475(1-2):335-43. (PMID: 25169076) Gastrointest Endosc. 2016 Sep;84(3):494-502.e1. (PMID: 26774353) Surg Laparosc Endosc Percutan Tech. 2012 Jun;22(3):272-8. (PMID: 22678327) Gastrointest Endosc. 2012 Apr;75(4):841-8. (PMID: 22301341) World J Gastroenterol. 2019 Feb 21;25(7):777-788. (PMID: 30809079) CA Cancer J Clin. 2021 May;71(3):209-249. (PMID: 33538338) Int J Pharm. 2016 Dec 30;515(1-2):535-542. (PMID: 27789369) Bioact Mater. 2021 Apr 18;6(11):3976-3986. (PMID: 33997487) Gastrointest Endosc. 2021 Feb;93(2):503-513.e5. (PMID: 32565186) Cell Mol Gastroenterol Hepatol. 2017 Sep 14;5(1):1-13. (PMID: 29276748) Gastrointest Endosc. 2004 Oct;60(4):539-43. (PMID: 15472675) Int J Biol Macromol. 1999 Dec 1;26(4):255-61. (PMID: 10569287) Gastrointest Endosc. 2017 Apr;85(4):693-699. (PMID: 27940101) J Control Release. 2020 Nov 10;327:747-765. (PMID: 32941931) Endosc Int Open. 2016 Jan;4(1):E1-E16. (PMID: 26793777) Adv Sci (Weinh). 2020 Nov 03;7(23):2001442. (PMID: 33304746) Sci Transl Med. 2020 Aug 26;12(558):. (PMID: 32848095) Adv Sci (Weinh). 2019 Jul 30;6(19):1901041. (PMID: 31592420) Dig Dis Sci. 2019 Oct;64(10):2955-2964. (PMID: 31165380) Endosc Int Open. 2019 Apr;7(4):E561-E567. (PMID: 30957006) J Artif Organs. 2015 Sep;18(3):191-8. (PMID: 26001772) Nat Nanotechnol. 2021 May;16(5):538-548. (PMID: 33526838) Gastrointest Endosc. 2006 Dec;64(6):958-65. (PMID: 17140905) Surg Endosc. 2022 Feb;36(2):1544-1553. (PMID: 33742273) J Gastroenterol Hepatol. 2002 Apr;17(4):382-8. (PMID: 11982716) Clin Gastroenterol Hepatol. 2020 Nov;18(12):2813-2823.e5. (PMID: 32526343) J Biomater Sci Polym Ed. 2016 Oct;27(15):1495-506. (PMID: 27416732) Endoscopy. 2004 Jul;36(7):579-83. (PMID: 15243878) Int J Biol Macromol. 2020 Dec 15;165(Pt B):2964-2973. (PMID: 33086112) Gut Liver. 2007 Jun;1(1):27-32. (PMID: 20485655) Bioact Mater. 2021 May 06;6(12):4455-4469. (PMID: 34027234) |
| فهرسة مساهمة: | Keywords: Endoscopic surgery; Gellan gum; Injectable hydrogel; Long-lasting barrier; Shear-thinning |
| تواريخ الأحداث: | Date Created: 20220407 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8940951 |
| DOI: | 10.1016/j.bioactmat.2021.11.026 |
| PMID: | 35386335 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!