دورية أكاديمية
أعرض في EDS

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis.

التفاصيل البيبلوغرافية
العنوان: Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis.
المؤلفون: Islam F; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh., Mitra S; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh., Nafady MH; Faculty of Applied Health Science Technology, Misr University for Science and Technology, Giza 12568, Egypt., Rahman MT; Department of Cardiology, Z.U Model Hospital, Feni 3900, Bangladesh., Tirth V; Mechanical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Asir, Saudi Arabia.; Research Center for Advanced Materials Science (RCAMS), King Khalid University, Guraiger, Abha 61413, Asir, P.O. Box No. 9004, Saudi Arabia., Akter A; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh., Emran TB; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh., Mohamed AA; Department of Forensic Medicine and Toxicology, Zagazig University, Zagazig 44511, Egypt., Algahtani A; Mechanical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Asir, Saudi Arabia.; Research Center for Advanced Materials Science (RCAMS), King Khalid University, Guraiger, Abha 61413, Asir, P.O. Box No. 9004, Saudi Arabia., El-Kholy SS; Department of Physiology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
المصدر: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2022 Mar 28; Vol. 2022, pp. 6144733. Date of Electronic Publication: 2022 Mar 28 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: eCollection Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2011- : New York, NY : Hindawi Pub.
Original Publication: Oxford, UK : Oxford University Press, c2004-
مستخلص: The present study examines the neuropharmacological and antidiabetic properties of methanol leaves extract of Lannea coromandelica in animal models. This study is carried out by elevated plus-maze apparatus, motor coordination, thiopental sodium has an induction role in sleeping time, hole board, hole cross, open field, antidiabetic studies. Mice were treated doses of 100, 150, and 200 mg/kg body weight in elevated plus-maze apparatus and motor coordination; 100 and 200 mg/kg body weight in sleeping time, hole cross, hole board, and open field tests; and 200 and 400 mg/kg body weight in the antidiabetic activity test. Extraction specifies a significantly decreased time duration and sleeping time in a thiopental sodium-induced sleeping time test. The experimental extract decreased locomotor and exploratory behaviors of mice in the open-field and hole-cross tests compared to the effects of the control. Furthermore, the extract increased sleeping time with a dose-dependent onset of action. The hole-board test extract also demonstrated a reduced number of head dips. The findings showed that L. coromandelica has potential neuropharmacological effects. In addition, in alloxan-induced diabetic mice, leaves extract at 200 and 400 mg/kg body weight revealed significant antidiabetic properties and could be used to manage blood glucose levels with more research.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2022 Fahadul Islam et al.)
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تواريخ الأحداث: Date Created: 20220407 Latest Revision: 20220408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8979700
DOI: 10.1155/2022/6144733
PMID: 35388308
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-427X
DOI:10.1155/2022/6144733