دورية أكاديمية
أعرض في EDS

Prevalence and patterns of symptoms of dysautonomia in patients with long-COVID syndrome: A cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Prevalence and patterns of symptoms of dysautonomia in patients with long-COVID syndrome: A cross-sectional study.
المؤلفون: Eldokla AM; Department of Neurology, State University of New York, Upstate Medical University, Syracuse, New York, 13210, USA.; Department of Pathology, State University of New York, Upstate Medical University, Syracuse, New York, 13210, USA., Mohamed-Hussein AA; Chest Department, Faculty of Medicine, Assiut University, Assiut, Egypt., Fouad AM; Department of Public Health, Occupational and Environmental Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Abdelnaser MG; Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt., Ali ST; Department of Neurology, State University of New York, Upstate Medical University, Syracuse, New York, 13210, USA., Makhlouf NA; Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt., Sayed IG; Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt., Makhlouf HA; Chest Department, Faculty of Medicine, Assiut University, Assiut, Egypt., Shah J; New York State Department of Health, Albany, New York, USA., Aiash H; Department of Family Medicine, Suez Canal University, Ismailia, Egypt.; Department of Cardiovascular Perfusion, State University of New York, Upstate Medical University, Syracuse, New York, 13210, USA.
المصدر: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2022 Jun; Vol. 9 (6), pp. 778-785. Date of Electronic Publication: 2022 Apr 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Periodicals, Inc on behalf of American Neurological Association Country of Publication: United States NLM ID: 101623278 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2328-9503 (Electronic) Linking ISSN: 23289503 NLM ISO Abbreviation: Ann Clin Transl Neurol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Hoboken, NJ] : Wiley Periodicals, Inc on behalf of American Neurological Association, [2014]-
مواضيع طبية MeSH: COVID-19*/complications , COVID-19*/epidemiology , Orthostatic Intolerance* , Primary Dysautonomias*/epidemiology , Primary Dysautonomias*/etiology, Cross-Sectional Studies ; Female ; Humans ; Male ; Prevalence ; Syndrome ; Post-Acute COVID-19 Syndrome
مستخلص: Background: The association between autonomic dysfunction and long-COVID syndrome is established. However, the prevalence and patterns of symptoms of dysautonomia in long-COVID syndrome in a large population are lacking.
Objective: To evaluate the prevalence and patterns of symptoms of dysautonomia in patients with long-COVID syndrome.
Methods: We administered the Composite Autonomic Symptom Score 31 (COMPASS-31) questionnaire to a sample of post-COVID-19 patients who were referred to post-COVID clinic in Assiut University Hospitals, Egypt for symptoms concerning for long-COVID syndrome. Participants were asked to complete the COMPASS-31 questionnaire referring to the period of more than 4 weeks after acute COVID-19.
Results: We included 320 patients (35.92 ± 11.92 years, 73% females). The median COMPASS-31 score was 26.29 (0-76.73). The most affected domains of dysautonomia were gastrointestinal, secretomotor, and orthostatic intolerance with 91.6%, 76.4%, and 73.6%, respectively. There was a positive correlation between COMPASS-31 score and long-COVID duration (p < 0.001) and a positive correlation between orthostatic intolerance domain score and post-COVID duration (p < 0.001). There was a positive correlation between orthostatic intolerance domain score and age of participants (p = 0.004). Two hundred forty-seven patients (76.7%) had a high score of COMPASS-31 >16.4. Patients with COMPASS-31 >16.4 had a longer duration of long-COVID syndrome than those with score <16.4 (46.2 vs. 26.8 weeks, p < 0.001).
Conclusions: Symptoms of dysautonomia are common in long-COVID syndrome. The most common COMPASS-31 affected domains of dysautonomia are gastrointestinal, secretomotor, and orthostatic intolerance. There is a positive correlation between orthostatic intolerance domain score and patients' age.
(© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
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تواريخ الأحداث: Date Created: 20220408 Date Completed: 20220614 Latest Revision: 20221207
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC9110879
DOI: 10.1002/acn3.51557
PMID: 35393771
قاعدة البيانات: MEDLINE
الوصف
تدمد:2328-9503
DOI:10.1002/acn3.51557