دورية أكاديمية
أعرض في EDS

Substantially elevated TSH, not traditional clinical subclinical thyroid disorder groupings, are associated with smaller LDL-P mean size: ELSA-Brasil.

التفاصيل البيبلوغرافية
العنوان: Substantially elevated TSH, not traditional clinical subclinical thyroid disorder groupings, are associated with smaller LDL-P mean size: ELSA-Brasil.
المؤلفون: Janovsky CCPS; Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address: carolina.janovsky@einstein.br., Goulart AC; Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Generoso G; Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Santos RD; Lipid Clinic Heart Institute (InCor) University of Sao Paulo, Medical, School Hospital, Sao Paulo, Brazil., Blaha MJ; Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, USA., Jones S; Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, USA., Toth PP; Department of Preventive Cardiology, CGH Medical Center, Sterling, IL, USA and Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, USA., Lotufo PA; Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Department of Internal Medicine, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Bittencourt MS; Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittisburgh, PA, USA., Benseñor IM; Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Department of Internal Medicine, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
المصدر: Journal of clinical lipidology [J Clin Lipidol] 2022 May-Jun; Vol. 16 (3), pp. 335-344. Date of Electronic Publication: 2022 Mar 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101300157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-2874 (Print) Linking ISSN: 18764789 NLM ISO Abbreviation: J Clin Lipidol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier
مواضيع طبية MeSH: Atherosclerosis*/complications , Hyperthyroidism*/complications , Hypothyroidism*/complications, Adult ; Female ; Humans ; Male ; Middle Aged ; Thyrotropin
مستخلص: Background: LDL appears to drive atherogenesis in overt hypothyroidism, but in subclinical dysfunction, its role is not completely elucidated.
Objective: The aim of this study was to evaluate subfractions of LDL in subclinical (SC) thyroid disorders.
Methods: Individuals were divided into three groups by baseline thyroid function (SC hypothyroidism, euthyroidism, and SC hyperthyroidism). LDL particle (LDL-P) subfractions were analyzed by Nuclear Magnetic Resonance (NMR) spectroscopy. The association between LDL-P subfractions and thyroid groups and quintiles was evaluated by linear regression models.
Results: We evaluated 3304 participants (54.1% women, 51.2% white, mean age 50.6 ± 8.7 years). In the univariate analysis, small LDL particle concentrations (SLDL-P) were not different between SC hypo- and hyperthyroidism compared to euthyroid individuals (p = 0.485 and p = 0.314, respectively). Large LDL-P (LDL-P) levels also did not differ in SC hyperthyroidism and SC hypothyroidism compared to euthyroidism (p = 0.698 and 0.788 respectively). Intermediate LDL-P levels were not different across the groups. These numbers did not materially change in multivariate analysis. However, we also analyzed LDL subfractions according to quintiles of TSH. We showed that in the higher TSH quintile LDL subfractions presented a significantly smaller mean size of LDL subfractions compared to the first quintile.
Conclusions: SC thyroid disorders are not associated with significant changes in LDL-P subfractions measured by NMR spectroscopy. However, it seems that the LDL mean size decreases as TSH levels increase, which may represent a more atherogenic lipid profile.
(Copyright © 2022. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: LDL subfractions; Small LDL; Subclinical thyroid diseases; TSH
المشرفين على المادة: 9002-71-5 (Thyrotropin)
تواريخ الأحداث: Date Created: 20220409 Date Completed: 20220616 Latest Revision: 20220623
رمز التحديث: 20221213
DOI: 10.1016/j.jacl.2022.03.010
PMID: 35396193
قاعدة البيانات: MEDLINE
الوصف
تدمد:1933-2874
DOI:10.1016/j.jacl.2022.03.010